Pharmaceutical Research and Reviews

  • Complexation of diclofenac sodium with hydroxy propyl betacyclodextrin improves its solubility and stability in ampoule solution which is determined by HPLC

    Complexation of diclofenac sodium with hydroxy propyl betacyclodextrin improves its solubility and stability in ampoule solution which is determined by HPLC Kahtan J.Hasson Al-Rasheed University College,department of Pharmacy,Baghdad,Iraq Diclofenac sodium injection is widely used in medicine as antinflamatory and antirheumatic agent with a therapeutic value of 25 mg / ml. However, diclofenac sodium is poorly soluble which forms a problem in its manufacturing as an injection. The available commercial products of diclofenac sodium ampoules have used different types of solubilizing…

  • Estimation of Some Phytochemicals in Swietenia macrophylla Leaves

    Estimation of Some Phytochemicals in Swietenia macrophylla Leaves *1Ushie O. A, 2Neji, P. A, 3Muktar, M, 2Ogah, E, 1Longbab, B.D and 1Olumide.V.B 1Department of Chemical Science, Federal University Wukari, Nigeria 2Department of Science Laboratory Technology, Binyaminu Usman Polytechnic, Hadejia. Jigawa State, Nigeria 3Dept of Chemical Sciences, Cross River University of Technology Calabar, Nigeria Extract of the leaf for the detection of the phytochemicals were obtained by soaking 100g of the sample in 250ml ethanol for forty-eight hours with frequent agitation….

  • Proximate Analysis and Phytochemeical Screening on Root of Cnidoscolus carumbium

    Proximate Analysis and Phytochemeical Screening on Root of Cnidoscolus carumbium *Neji, P. A1, Ushie O. A2, Alobi, N. O3, Neji, H. A4 and Etim, A. N5 1,3& 5Dept of Chemical Sciences, Cross River University of Technology, Calabar Nigeria 2Dept of Chemical Sciences, Federal University, Wukari Nigeria 4Dept of Science Education, University of Calabar, Nigeria The root of Cnidoscolus carumbium was soaked in water for 48 hours and filtered. The residue was oven dried at 800C for 4hrs. Further extraction process…

  • An Overview On Diabetes

    An Overview On Diabetes R.Ramasubramania raja M.Sekar P.Lathasri, Paula preethi Department of Pharmacognonsy, Narayana Pharmacy college, Nellore, A.P In India more than 62 million diabetic individuals currently diagnosed with the disease. The prevalence of diabetes is more in India and is increasing rapidly. Herbal formulations are preferred due to lesser side effects and low cost. A list of medicinal plants with proven antidiabetic and related beneficial effects of herbal drug used in treatment of diabetes is compiled. Keywords: diabetic, India,…

  • Utility of Marine Organisms as a Drug Source: the Perspective

    Utility of Marine Organisms as a Drug Source: the Perspective Pt. (Dr.) Kartikay Pandey¹*, Chakra Chalamala² ¹Researcher, “Dr. Pandey’s Laboratories and Research Foundation”, Lucknow, India. ²7150 North Maple Avenue, Fresno CA, 93720, USA. More than 70% of our planet’s surface is covered with sea/salty water. Even the world’s oldest, most revered and holiest texts, the Vedas, term the Ocean as ‘Ratnakar’, or the bestower of immense riches. From pre-historic times the ocean/marine world has been a source of inspiration, awe…

  • Alkaloids an overview

    Alkaloids – an overview R.Ramasubramania raja, M.Likitha, M.Sekar Department of pharmacognosy, narayana pharmacy college Nellore,A.P Alkaloids are a chemically heterogenous group of natural substances and comprises more than 6000 basic nitrogen containing organic compounds which occur in about 15 percent of all vascular terrestrial plants and in more than 150 different plants families. The alkaloids exhibit diversity of structures and also show an extraordinary spectrum of pharmacological activities. Because of these characters, they are important for chemical, physiological, taxonomic and…

  • Molar characterization and analytical UPLC method development of matrix impurity, disregards impurity, specified impurity associated undetectable impurity of laboratory drug Isatin

    Molar characterization and analytical UPLC method development of matrix impurity, disregards impurity, specified impurity associated undetectable impurity of laboratory drug Isatin Rahul Hajare Post Doc Fellow (Batch 2013-2015) Indian Council of Medical Research, New Delhi This is out line work on the process development for the impurity detection of Isatin from synthetic occurring and several new methods have been developed during the pursuit of this research. The article traces the evolution of various approaches and provides a comparison for overall…

  • Lead Developer Angular and Effect of Force by Side Chain of Suicide Molecule in HIV AIDS Drug Discovery

    Lead Developer Angular and Effect of Force by Side Chain of Suicide Molecule in HIV AIDS Drug Discovery Rahul Hajare Post Doc Fellow (Batch 2013-2015) Indian Council of Medical Research, New Delhi Angular to lead (A2L) accepted as lead generation has stage in early drug discovery where small molecule hits from a high throughput screen (HTS) has evaluated and undergo limited optimization to identify promising lead compounds. These lead compounds undergo more extensive optimization in a subsequent step of drug…

  • Chemical profiling of Solanum lycopersicum

    Chemical profiling of Solanum lycopersicum Neji, P. A1 *Ushie O. A2, Neji, H. A3 Opara, I. J2 and Ojong, O. O4 1Dept of Chemical Sciences, Cross River University of Technology, Calabar Nigeria 2 Dept of Chemical Science, Federal University, Wukari Nigeria 3 Dept of Science Education, University of Calabar, Calabar 4Dept of Pure and Applied Chemistry, University of Calabar Consumed in diverse ways, including raw, as an ingredient in many dishes, sauces, salads and drinks, tomato is the edible, often…

  • Application of Ratio Derivative Spectrophotometry for Simultaneous Determination of Clonazepam and Paroxetine Hydrochloride in Tablet Dosage Form

    Application of Ratio Derivative Spectrophotometry for Simultaneous Determination of Clonazepam and Paroxetine Hydrochloride in Tablet Dosage Form Jalpa U. Patel*1, Himani Dalwadi2 ,Dr. Purvi Shah3 1Indukaka Ipcowala College of Pharmacy, Beyond GIDC, P.B. No. 53, Vitthal Udyognagar 388 121, Gujarat, India. 2Indukaka Ipcowala College of Pharmacy, Beyond GIDC, P.B. No. 53, Vitthal Udyognagar 388 121, Gujarat, India. 3Anand Pharmacy College,Near town hall,Anand-388001 Ratio derivative spectrophotometric method has been developed for the simultaneous estimation of Clonazepam and Paroxetine hydrochloride in pharmaceutical…