Prevalence and Drug Resistance Patterns of Staphylococcus aureus in Food Producing Animals, Their Products and Humans

Review on the Prevalence and Drug Resistance Patterns of Staphylococcus aureus in Food Producing Animals, Their Products and Humans

Fitsum Tessema*

Fitsum Tessema, Hawassa Agricultural Research Center, P.O.Box 2126, Hawassa, Ethiopia

International Journal of Bioscience and MedicineStaphylococcus aureus is a gram positive bacterium that belongs to coagulase positive staphylococcus. It is widely distributed in the environment and causes diseases due to direct infection or due to the production of toxins by the bacteria. The prevalence of S. aureus ranges from 4% to 83% in different countries of the world from samples of food producing animals and their products. In Ethiopia the lowest and highest prevalence is reported as 4.2% and 48.75%, respectively. All mammals and birds are susceptible to colonization with S. aureus. Staphylococcus aureus can be treated with a wide range of antibiotics but there are efficient and inefficient antibiotics. Antibiotic resistance tests that have been conducted in different countries revealed that S. aureus were highly resistant to Ampicillin, Cloxacillin and Penicillin and less susceptible to Vancomycin and Rifampicin. The emergence of methicillin resistant Staphylococcus aureus in animal and human has become a worldwide problem.

Keywords: Staphylococcus aureus, Prevalence, Drug resistance, Food producing animal

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Fitsum Tessema. Review on the Prevalence and Drug Resistance Patterns of Staphylococcus aureus in Food Producing Animals, Their Products and Humans. International Journal of Bioscience and Medicine, 2017; 1:5. DOI: 10.28933/ijbm-2017-09-2003


1. Abera M, Demie B, Aragaw K, Regassa F and Regassa A (2013a) Isolation and identification of Staphylococcus aureus from bovine mastitic milk and their drug resistance patterns in Adama town, Ethiopia. African Journal of Dairy Farming and Milk Production, 1 (2):19-23.
2. Abera B, Diriba L and Iticha I (2013b) Study of bovine mastitis in Asella government dairy farm of Oromia regional state, south eastern Ethiopia. International journal of current research and academic review. 1(2): 134-135.
3. Abera M, Habte T, Aragaw K, Asmare K and Sheferaw D (2012) Major causes of mastitis and associated risk factors in smallholder dairy farms in and around Hawassa, Southern Ethiopia. Trop Anim Health Prod, 44: 1175-1179.
4. Abunna F, Abriham T, Gizaw F, Beyene T, Feyisa A, Ayana D, Mamo B and Duguma R (2016) Staphylococcus: Isolation, Identification and Antimicrobial Resistance in Dairy Cattle Farms, Municipal Abattoir and Personnel in and Around Asella, Ethiopia. J Vet Sci Technol. 7: 383.
5. Abunna F, Fufa G, Megersa B and Regassa A (2013) Bovine Mastitis: Prevalence, Risk Factors and Bacterial Isolation in Small-Holder Dairy Farms in Addis Ababa City, Ethiopia. Global Veterinaria, 10 (6): 647-652.
6. Addis M, Pal M and Kyule M (2011) Isolation and identification of Staphylococcus species from Ethiopian Cottage Cheese (Ayib) in Bishoftu, Ethiopia. Vet. Res., 4: 13-17.
7. Aguilar J, Urday-Cornejo V, Donabedian S, Perri M, Tibbetts R and Zervos M (2010) Staphylococcus aureus Meningitis Case Series and Literature Review. Medicine, 89(2).
8. Amare A, Mohammed-Amin A, Shiferaw A, Nazir S and Negussie H (2013) Yolk Sac Infection (Omphalitis) in Kombolcha Poultry Farm, Ethiopia. American-Eurasian Journal of Scientific Research, 8 (1): 10-14.
9. Argudin M A, Mendoza M C and Rodicio M R (2010) Food Poisoning and Staphylococcus aureus Enterotoxins. Toxins, 2: 1751-1773.
10. Ayano A A, Hiriko F, Simyalew A M and Yohannes A (2013) Prevalence of subclinical mastitis in lactating cows in selected commercial dairy farms of Holeta district. Journal of Veterinary Medicine and Animal Health, 5(3): 67-72.
11. Batha G F, Rensburga A J, Petteya K P V, Vuurenb M V and Kidanemariam A (2011) A literature review and investigation of staphylococcal necrotic dermatitis in sheep. Jl, 82(4): 227–231.
12. Bhargava K, Wang X, Donabedian S, Zervos M, da Rocha L and Zhang Y (2011) Methicillin-Resistant Staphylococcus aureus in Retail Meat, Detroit, Michigan, USA.Emerging infectious disease, 17(6).
13. Bjorland J, M Sunde and S Waage (2001) Plasmid-borne smr gene causes resistance to quaternary ammonium compounds in bovine Staphylococcus aureus. J. Clin. Microbiol. 39:3999–4004.
14. Boer E D, Zwartkruis-Nahuis J T M, Wit B, Huijsdens X W, Neeling A J, Boschc T, Oosteromb R A A, Vila A and Heuvelink A E (2009) Prevalence of methicillin-resistant Staphylococcus aureus in meat. International Journal of Food Microbiology, 134:52–56.
15. Butterworth A (1999) Infectious components of broiler lameness: A review. World’s Poultry Science Journal, 56(4):327-352.
16. Chen W C, Wang J L, Wang J T, Chen, Y.C. and Chang S C (2008) Spinal epidural abscess due to Staphylococcus aureus: clinical manifestations and outcomes. J Microbiol Immunol Infect., 41:215-221.
17. Daka D, G/silassie G and Yihdego D (2012) Antibiotic resistance Staphylococcus aureus isolated from cow’s milk in the Hawassa area, South Ethiopia. Annals of Clinical Microbiology and Antimicrobials, 11: 26-31.
18. Davis J P, Chesney P J, Wand P J and LaVenture M N (1980) Toxic-shock syndrome: epidemiologic features, recurrence, risk factors, and prevention. Engl J Med., 18:1429-1435.
19. De Oliveira A P, Watts J L, Salmon S A and Aarestrup F M (2000) Antimicrobial Susceptibility of Staphylococcus aureus Isolated from Bovine Mastitis in Europe and the United States. Journal of Dairy Science, 83(4): 855–862.
20. Desissa F, Makita K, Teklu A and Grace D (2013) Contamination of informally marketed bovine milk with Staphylococcus aureus in urban and peri urban areas of Debre-Zeit, Ethiopia. African Journal of Dairy Farming and Milk Production, 1 (1): 008-011.
21. Dinges M M, Orwin P M and Schlievert P M (2000) Exotoxins of Staphylococcus aureus. Clinical microbiology reviews, 13(1): 16-34.
22. Duran N, Ozer B, Duran, G G, Yusuf Onlen and Demir C (2012) Antibiotic resistance genes and susceptibility patterns in Staphylococci. Indian J Med Res, 135: 389-396.
23. Ebrahimi A, Shams N, Shahrokh S and Mirshokraei P (2010) Characteristics of Staphylococci isolated from mastitic goat milk in Iranian dairy herds. Veterinary World, 3(5): 205-208.
24. Edwards J F, Lassala A L and Spencer T E (2008) Staphylococcus associated Abortions in Ewes with Long-term Central Venous Catheterization. Vet Pathol, 45: 881.
25. Fernandez G M L, González L J J, Goyenechea A, Fraile J and De-Górgolas M (2009) Endocarditis caused by Staphylococcus aureus: A reappraisal of the epidemiologic, clinical and pathologic manifestations with analysis of factors determining outcome. Medicine (Baltimore), 88(1):1-22.
26. Filimon M N, Borozan A B, Gotia S L, Popescu R, Gherman V D (2009) Testing the sensitivity of Staphylococcus aureus Antibiotics. Analele Universititii din Oradea, Fascicula Biologie.
27. Foster A P (2012) Staphylococcal skin disease in livestock. Vet Dermatol., 23(4):342-351.
28. Fowler V G, Sanders L L, Kong L K, McClelland R S, Gottlieb G S, Li J, Ryan T, Sexton D J and Roussakis G (1999) Endocarditis Due to Staphylococcus aureus: 59 Prospectively Identified Cases with Follow-up. CID, 28.
29. Fridkin S K, Hageman J C, Morrison M, Sanza L T, Como-Sabetti K, Jernigan J A, Harriman K, Harrison L H, Ruth L, and Farley M M (2005) Methicillin-Resistant Staphylococcus aureus Disease in Three Communities, for the Active Bacterial Core Surveillance Program of the Emerging Infections Program Network. n engl j med., 352;1436- 1444.
30. Gebrewahid T T, Abera B H and Menghistu H T (2012) Prevalence and Etiology of Subclinical Mastitis in Small Ruminants of Tigray Regional State, North Ethiopia. Vet. World, 5(2): 103-109.
31. Gebremichael L, Deressa B, Begna F and Mekuria A (2013) Study on prevalence of bovine mastitis in lactating cows and associated risk factors in and around Areka town, Southern of Ethiopia. Glob. J. Ind. Microbiol., 1 (1): 017-022.
32. Gordon J J, Harter D H and Phair J P (1985) Meningitis due to Staphylococcus aureus. The American Journal of Medicine, 78(6): 965–970.
33. Graham P L, Lin S X and Larson E L (2006) A U.S. population-based survey of Staphylococcus aureus colonization. Ann Intern Med., 144: 318–325.
34. Hageman J C, Uyeki T M, Francis J S, Jernigan D B, Wheeler J G, Bridges C B, Barenkamp S J, Sievert D M, Srinivasan A, Doherty M C, McDougal L K, Killgore G E, Lopatin U A, Coffman R, MacDonald J K, McAllister S K, Fosheim G E, Patel J B and McDonald L C (2006) Severe Community-acquired Pneumonia Due to Staphylococcus aureus. Emerg Infect Dis., 12(6):894.
35. Husein A, Haftu B, Hunde A and Tesfaye A (2013) Prevalence of camel (Camelus dromedaries) mastitis in Jijiga Town, Ethiopia. African Journal of Agricultural Research, 8(24): 3113-3120.
36. Hussain S, Shams R, Ahmad K, Perveen R and Riaz B (2005) Prevalence of methicillin resistant Staphylococcus aureus (MRSA) in surgical site infections in a tertiary care hospital. Journal Pathol, 3(2):81–85.
37. Jaber N N (2011) Isolation and biotyping of Staphylococcus aureus from white cheese in basrah local markets. Bas.J.Vet.Res., 10(2): 55-66.
38. Kahsay A, Mihret A, Abebe T and Andualem T (2014) Isolation and antimicrobial susceptibility pattern of Staphylococcus aureus in patients with surgical site infection at Debre Markos Referral Hospital, Amhara Region, Ethiopia. Archives of Public Health, 72:16.
39. Katsande S, Matope G, Ndengu M and Pfukenyi D M (2013) Prevalence of mastitis in dairy cows from smallholder farms in Zimbabwe. Journal of Veterinary Research, 80(1).
40. Kejela T and Bacha K (2013) Prevalence and antibiotic susceptibility pattern of methicillin resistant Staphylococcus aureus (MRSA) among primary school children and prisoners in Jimma Town, Southwest Ethiopia. Annals of Clinical Microbiology and Antimicrobials, 12:11.
41. Koop G, Rietman J F and Pieterse M C (2010) Staphylococcus aureus mastitis in Texel sheep associated with sucking twins. Veterinary record, 167:868-869.
42. Le Loir Y, Baron F and Gautier M (2003) Staphylococcus aureus and food poisoning. Genetics and Molecular Research, 2(1):63–76.
43. Li J P, Zhou H J, Yuan L, He T and Hu S H (2009) Prevalence, genetic diversity, and antimicrobial susceptibility profiles of Staphylococcus aureus isolated from bovine mastitis in Zhejiang Province, China. J Zhejiang Univ Sci B., 10(10): 753–760.
44. Megersa B, Manedo A, Abera M, Regassa A and Abunna F (2012) Mastitis in Lactating Cows at Hawassa Town: Prevalence, Risk Factors, Major Bacterial Causes and Treatment Response to Routinely Used Antibiotics. American-Eurasian Journal of Scientific Research, 7 (2): 86-91.
45. Mekibib B, Furgasa M, Abunna F, Megersa B and Regassa A (2010) Bovine Mastitis: Prevalence, Risk Factors and Major Pathogens in Dairy Farms of Holeta Town, Central Ethiopia. Veterinary World, 3(9):397-403.
46. Mekuria A, Asrat D, Woldeamanuel Y and Tefera G (2013) Identification and antimicrobial susceptibility of Staphylococcus aureus isolated from milk samples of dairy cows and nasal swabs of farm workers in selected dairy farms around Addis Ababa, Ethiopia. African journal of microbiology research, 7(27): 3501-3510.
47. Moges N, Asfaw Y, Belihu K and Tadesse A (2011) Antimicrobial Susceptibility of Mastitis Pathogens from Smallholder Dairy Herds in and Around Gondar, Ethiopia. Journal of Animal and Veterinary Advances Year, 10 (12): 1616-1622.
48. Moon J S, Lee A R, Kang H M, Lee E S, Joo Y S, Park Y H, Kim M N and Koo H C (2007) Antibiogram and coagulase diversity in staphylococcal enterotoxin-producing Staphylococcus aureus from bovine mastitis. Journal of Dairy Science, 90(4):1716-1724.
49. Mork T, Tollersrud T, Kvitle B, Jorgensen H J and Waage S (2005) Comparison of Staphylococcus aureus genotypes recovered from cases of bovine, ovine, and caprine mastitis. J Clin Microbiol, 43:3979–3984.
50. Okwu M U, Mitsan O and Okeke O P (2014) Prevalence and antimicrobial susceptibility profiles of community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) isolates among healthy individuals in Okada, South-South, Nigeria. US Open Pharmaceutical, Biological & Chemical Sciences Journal, 1(1): 1 – 9.
51. Peake S L, Peter J V, Chan L, Wise R P, Butcher A R and Grove D I (2006) First Report of Septicemia Caused by an Obligately Anaerobic Staphylococcus aureus Infection in a Human. J Clin Microbiol., 44(6): 2311–2313.
52. Rahimi E (2013) Enterotoxigenicity of Staphylococcus aureus isolated from traditional and commercial dairy products marketed in Iran. Brazilian Journal of Microbiology, 44(2): 393-399.
53. Rasheed B Y (2011) Isolation and identification of bacteria causing arthritis in chickens. Iraqi Journal of Veterinary Sciences, 25(2): 93-95.
54. Rathore P and Kataria A K (2012) Antimicrobial susceptibility profiling of Staphylococcus aureus of camel (Camelus dromedarius) skin origin. ABAH Bioflux., 4(2): 47-50.
55. Regassa A, Golicha G, Tesfaye D, Abunna F and Megersa B (2013) Prevalence, risk factors, and major bacterial causes of camel mastitis in Borana Zone, Oromia Regional State, Ethiopia. Tropical Animal Health and Production, 45 (7):1589.
56. Ribeiro M G, Lara G H B, Bicudo S D, Souza A V G, Salerno T, Siqueira A K and Geraldo J S (2007) An unusual gangrenous goat mastitis caused by Staphylococcus aureus, Clostridium perfringens and Escherichia coli co–infection. Arq. Bras. Med. Vet. Zootec., 59(3):810-812.
57. Rubinstein E, Kollef M H and Nathwani D (2008) Pneumonia Caused by Methicillin- Resistant Staphylococcus aureus. Clin Infect Dis., 46 (5): 378-385.
58. Sarkar P, Mohanta D, De S and Debnath C (2014) Staphylococcus aureus in dairy animals and farm workers in a closed herd in Karnal, North India: Assessment of prevalence rate and COA variations. International Journal of Innovative Research in Science, Engineering and Technology, 3(4).
59. Scott P R and Murphy S (1997) Outbreak of staphylococcal dermatitis in housed lactating Suffolk ewes. Veterinary Record, 140:631–632.
60. Shareef A M, Mansour R S and Ibrahim K K (2009) Staphylococcus aureus in commercial breeder layer flocks. Iraqi Journal of Veterinary Sciences, 23:63-68.
61. Sharmaa I and Brintya A (2014) Isolation and Identification of Staphylococcus aureus from Bovine Mastitis Milk and Their Drug Resistance Patterns in Silchar Town Dairy Farms, N.E India. Online International Interdisciplinary Research Journal, 4: 256-259.
62. Shearer J K and Harris B (1992) Mastitis in Dairy Goats.
63. Shitandi A, Anakalo G, Galgalo T and Mwangi M (2004) Prevalence of bovine mastitis amongst small holder dairy herds in Kenya. Israel journal of veterinary medicine, 59:1-2.
64. Shittu A O, Okon K, Adesida S, Oyedara O, Witte W, Strommenger B, Layer F and Nubel U (2011) Antibiotic resistance and molecular epidemiology of Staphylococcus aureus in Nigeria. BMC Microbiology, 11:92.
65. Siegrist J (2011) Staphylococcus aureus in the focus. Microbiology focus, 3(4): 2-5.
66. Smith E M, Green L E, Medley G F, Bird H E and Dowson C G (2005) Multilocus sequence typing of Staphylococcus aureus isolated from high-somatic-cell-count cows and the environment of an organic dairy farm in the United Kingdom. J. Clin. Microbiol., 43:4731-4736.
67. Stewart C M (2003) Staphylococcus aureus and staphylococcal enterotoxins. Ch 12 In: Hocking AD (ed) Foodborne microorganisms of public health significance. 6th ed, Australian Institute of Food Science and Technology (NSW Branch), Sydney, p. 359–380.
68. Suelam I I A, Raslan, A R A and Mohamed M E M (2012) Isolation of Staphylococcus aureus from Milk and Human with Reference to its Survival on Surfaces. World Journal of Dairy and Food Sciences, 7 (2): 142-145.
69. Suleiman A, Zaria L T, Grema H A and Ahmadu P (2013) Antimicrobial resistant coagulase positive Staphylococcus aureus from chickens in Maiduguri, Nigeria. Sokoto Journal of Veterinary Sciences, 11(1): 51-55.
70. Sung J M, Lloyd D H and Lindsay J A (2008) Staphylococcus aureus host specificity: comparative genomics of human versus animal isolates by multi-strain microarray. Microbiology, 154:1949–1959.
71. Taddesse Z, Tiruneh M and Gizachew M (2014) Staphylococcus aureus and its Antimicrobial Susceptibility Pattern in Patients, Nasal carriage of Health Personnel, and objects at Dessie referral hospital, Northern Ethiopia. Global Journal of Medical Research: Microbiology and Pathology, 14(2): 29-35.
72. Tessema F (2016) Prevalence and Drug Resistance Patterns of Staphylococcus aureus in Lactating Dairy Cow’s Milk in Wolayta Sodo, Ethiopia. EC Veterinary Science, 2(5): 226-230.
73. Tessema F, Abunna F, Duguma R., Beyene T, Bihonegn A, Worku T, Adugna B and Almazu M (2016) Drug resistance pattern of Staphylococcus in poultry in central and southern Ethiopia. Global Journal of Science Frontier Research (D): Agriculture and Veterinary, 16(2): 30-36.
74. Thaker H C, Brahmbhatt M N and Nayak J B (2013) Isolation and identification of Staphylococcus aureus from milk and milk products and their drug resistance patterns in Anand, Gujarat. Veterinary World, 6(1):10-13.
75. Turutoglu H, Tasci F and Ercelik S (2005) Detection of Staphylococcus aureus in milk by tube coagulase test. Bull Vet Inst Pulawy, 49: 419-422.
76. Udegbunam S O, Udegbunam R I and Anyanwu M U (2014) Occurrence of Staphylococcal Ocular Infections of Food Producing Animals in Nsukka Southeast, Nigeria. Veterinary Medicine International.
77. Uwaezuoke J C and Aririatu L E (2004) A Survey of Antibiotic Resistant Staphylococcus aureus Strains from Clinical Sources in Owerri. J. Appl. Sci. Environ. Mgt., 8 (1): 67 – 69.
78. Wertheim H F, Melles D C, Vos M C, Van Leeuwen W and Van Belkum A (2005) The role of nasal carriage in Staphylococcus aureus infections. Lancet Infectious Disease, 5: 751–762.
79. Yohannis M and Molla W (2013) Prevalence, risk factors and major bacterial causes of bovine mastitis in and around Wolaita Sodo, Southern Ethiopia. African Journal of Microbiology Research, 7(48): 5400-5405.
80. Zeryehun T, Aya T and Bayecha R (2013) Study on prevalence, bacterial pathogens and associated risk factors of bovine mastitis in small holder dairy farms in and around Addis Ababa, Ethiopia. Journal of Animal and Plant Science. 23(1):50-55.