Review Article of International Journal of Aging Research
Alzheimer’s Disease and Overload of Informal Caregivers
Ian James Martins
aCentre of Excellence in Alzheimer’s Disease Research and Care, Sarich Neuroscience Research Institute, Edith Cowan University, Verdun Street, Nedlands, 6009, Western Australia, Australia; bSchool of Psychiatry and Clinical Neurosciences, The University of Western Australia, Nedlands, 6009; cMcCusker Alzheimer’s Research Foundation, Hollywood Medical Centre, 85 Monash Avenue, Suite 22, Nedlands, 6009, Australia
The process of aging is determined by various genetic and environmental factors. Aging is associated with increased oxidative stress that alters cellular chromatin structure, DNA methylation with histone modifications. These epigenetic alterations lead to nuclear changes associated with mitochondrial apoptosis that is a major defect in the global chronic disease epidemic (1). The variability in longevity between individuals in different communities implicate various nutritional and environmental factors involved in transcriptional dysregulation that lead to cell damage that accumulates with age and contributes to mitophagy, insulin resistance and programmed cell death. The absence or malfunction of a gene (2) necessary for transcriptional regulation of gene expression, DNA repair and telomere maintenance in neurons has become essential with relevance to neurodegeneration that determines aging and lifespan.
Keywords: longevity; species; appetite; immune system; human; mitophagy; animals; neurodegneration; Sirtuin 1; nutritional therapy
How to cite this article:
Ian James Martins. Anti-Aging Gene linked to Appetite Regulation Determines Longevity in Humans and AnimalsInternational Journal of Aging Research, 2018, 1:6. DOI:10.28933/ijoar-2018-05-1101
1. Ian James Martins. Genomic Medicine and Acute Cardiovascular Disease Progression in Diabetes. International Journal of Medical Studies. 2018;3(1):124-130.
2. Sandra Rodríguez-Rodero, Juan Luis Fernández-Morera, Edelmiro Menéndez-Torre, Vincenzo Calvanese, Agustín F. Fernández, Mario F. Fraga. Aging Genetics and Aging. Aging and Disease. 2011;2(3):186-195.
3. Giuseppe Passarino, Francesco De Rango, Alberto Montesanto. Human longevity: Genetics or Lifestyle? It takes two to tango. Immunity and Ageing. 2016;13:(12):1-6.
4. Nir Barzilai, Alan R. Shuldiner. Searching for Human Longevity Genes: The Future History of Gerontology in the Post-genomic Era. Journal of Gerontology, 2001;56A(2):M83–M87.
5. Michal Jazwinski. Longevity, Genes, and Aging. Science. 1996;27(5271):54-59.
6. Kristen Fortney, Edgar Dobriban, Paolo Garagnani, Chiara Pirazzini, Daniela Monti, Daniela Mari, Gil Atzmon, Nir Barzilai, Claudio Franceschi, Art B. Owen, Stuart K. Kim. Genome-Wide Scan Informed by Age-Related Disease Identifies Loci for Exceptional Human Longevity. PLOS Genetics, 2015; 11(12): e1005728
7. Diddahally Govindaraju, Gil Atzmonb, Nir Barzilai. Genetics, lifestyle and longevity: Lessons from centenarians. Applied and Translational Genomics. 2015;4:23-32.
8. Ian James Martins. Anti-Aging Genes Improve Appetite Regulation and Reverse Cell Senescence and Apoptosis in Global Populations. Advances in Aging Research, 2016; 5:9-26.
9. Ian James Martins. Appetite dysregulation and obesity in Western Countries Ian J Martins · Edited by Emma Jones,; LAP LAMBERT Academic Publishing. 2013;1-80.
10. Ian James Martins. Single Gene Inactivation with Implications to Diabetes and Multiple Organ Dysfunction Syndrome. Journal of Clinical Epigenetics. 2017;3(24): 1-8.
11. Ian James Martins. Appetite Control and Biotherapy in the Management of Autoimmune Induced Global Chronic Diseases. Journal of Clinical Immunology and Research. 2018; 2(1): 1-4.
12. Ian James Martins. Regulation of Core Body Temperature and the Immune System Determines Species Longevity. Current Updates in Gerontology. 2017; 1: (6.1):1-6.
13. Ian James Martins. Food quality induces a miscible disease with relevance to Alzheimer’s disease and Neurological diseases. Journal of Food Research.2016; 5(6): 45-52.
14. Ian James Martins. Dietary Interventions Reverse Insulin and Synaptic Plasticity Defects Linking to Diabetes and Neurodegenerative Diseases. SL Nutrition and Metabolism. 2017; 1(111)1-5.
15. Ian James Martins. Caffeine with Links to NAFLD and Accelerated Brain Aging. Chapter: Non-Alcoholic Fatty Liver Disease – Molecular Bases, Prevention and Treatment. InTech – Open Science Open Minds | InTechOpen. 2017.
16. Ian James Martins. Indian Spices and Biotherapeutics in Health and Chronic Disease. Health. 2018;10:374-380.
17. Ian James Martins. Antimicrobial activity inactivation and toxic immune reactions induce Epilepsy in human. Journal of Medical Discovery. (2017);2(4):1-7.