Review Article of American Journal of Microbiology and Immunology
Observed variations of Plasma Procalcitonin Amonsgt Sexually Active Males With Suspected Bacterial-Urogenital Infection In Yola Metropolis
Ibeh N.Isaiah1, Omobogie E. NORAH
1Department of Health Services, University of Benin PMB 1154
Background: Male urogenital infection in Nigeria has increased due to alarming rise of unprotected sex amongst the sexually active males in Nigeria. Most of these case leads to a limiting advanced disease state such as kidney infections, bacteropsermia/infertility and reinal failure. AIM: To study the elevated serum Procalcitonin levels on patients with bacterial urogenital infections as an adjunct of bacterial-fungi-viral urogenital infections for diagnosis/prognosis and antimicrobial monitoring. PATIENTS and METHODS: The study group cut across adults from the ages of 20 years and above, 40 males who were suspected to have urogenital infection and 40 who were confirmed cases of urogenital infections those with suspected urogenital infections and those with confirmed urogenital infections. Using standard microbiological techniques urine and urethral swabs were taking and proper cultural techniques were carried out to isolate the bacterial/Fungi origin of infection, blood samples were collected from patients with suspected and confirmed urogenital infections for further analysis of the Procalcitonin ratio. RESULT: a total of 40 suspected males with signs and symptoms of urogenital infections where included in this study, a microbiological analysis was carried out on MSU(midstream urine clean catch) and urethral swab, and seminal fluid analysis, 40% yielded growth of gram Staphylococcus aureus and CoNs, 22.5% yielded growths of Escherichia coli, Proteus mirabilis, Acinectobacter spp, Klebseilla oxytoca while 15% had fungi/Parasitic origins,( Candida albicans and Trichomonas vaginalis) 22.5% showed no significant growth. The mean PCT ratio across the infectious agents were, bacterial origin ( 0.4-1.1 CI 0.34-0.62) fungi/parasitic origin (0.3-1.0 CI 0.28-0.56) Conclussion: although there was no remarkable difference between the confirmed cases of urogenital infection and suspected cases this showed the accuracy of PCT and its use. The reasonable increased levels of PCT in urogenital infections may serve as prognosis for asypmtomatic cases which often result to infertility, although most of the suspected cases where in the hospital wards either with prolonged chronic reinal failure or urinary tract infection this poses an interest to link clinical isolation of pathogenic organism and a symbiotic relationship of serologic PCT monitoring.
Keywords: Procalcitonin, Urogenital Infections, Infertility