Methi (Trigonella Foenum-Graecum): A Multifunctional Herbal Drug


Methi (Trigonella Foenum-Graecum): A Multifunctional Herbal Drug


Anju*, Mohammad Idris**

*Research Associate, Central Council for Research in Unani Medicine, New Delhi, India
**Principal & Head, PG Departments of Ilm-us-Saidla, Ayurvedic & Unani Tibbia College & Hospital, Karol Bagh, New Delhi, India


Herbal medicines are one kind of dietary supplement, and they are used for their scent, flavor, or therapeutic properties. Methi or Trigonella foenum-graecum (TFG) belonging to the family Fabaceae is an aromatic perennial herb which is cultivated throughout India. It is widely used in cosmetic and flavoring industries. It is included in the formulations used for cholasma, improving complexion and beautification. According to Unani classical literature, its suppository was made in conjunction with duck fat and introduced into the body to cure scirrhus of the uterus and its mouth opened up. It is extensively used for several human diseases mentioned in Unani system of medicine. Various scientific/ experimental studies have been performed presently on TFG namely, phytochemical, physicochemical, pharmacological and clinical studies. In this review, Various actions and clinical indications have been elaborated in the Unani classical literature and some properties namely Anti-inflammatory, An-diabetic, Antiarthritic, Antiglycemic, Antioxidant and Anti-stress activities have been revalidated in the light of recent scientific researches. Significant information about methi as a traditional herbal medicine is provided in this review.


Keywords: Methi, Hulba, Trigonella foenum-graecum, Unani System of medicine, Herbal drug.


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How to cite this article:
Anju, Mohammad Idris. Methi (Trigonella Foenum-Graecum): A Multifunctional Herbal Drug. Journal of Herbal Medicine Research, 2018,3:26.. DOI:10.28933/xxxxxx


REFERENCES
1. Anonymous. The wealth of India. First supplement series. Volume V. National Institute of Science Communication and Information Resources (NISCAIR), New Delhi, 2007; pp:51-52.
2. Bnouham M, Mekhfi, Legssyer A, Ziyyat A. Medicinal Plants Used in the Treatment of Diabetes in Morocco. International Journal of Diabetes and Metabolism, 2002; 10:33-50.
3. Prajneshu M and Gupta VK. Traditional Knowledge Database-IPR & Opportunities for Research & Development, Journal of Intellectual Property Rights,2001; 6: 449-458
4. Moorthy AL, Pant A. Knowlwdge Management and Safeguarding Indian traditional knowledge. Annals of Library & Information Studies, 2012; 60: 88-97.
5. Sreeja S, Anju V.S. & S. Sreeja. In vitro Estrogenic Activities of Fenugreek Trigonella foenum graecum Seeds. Indian Journal of Medical Research, 2010; 131:814-819.
6. Subhashini N, Thangathirupathi A, Lavanya N, (2011). Antioxidant Activity of Trigonella Foenum Graecum using various in Vitro and Ex Vivo Models. International Journal of Pharmacy and Pharmaceutical Sciences;3 (2):96-102.
7. Petropoulos GA (Ed). Fenugreek: The Genus Trigonella. CRC Press. Boca Raton.London, 2012;pp:1-35.
8. Ghani N. Khazain-ul-Advia. Idara Kitab ul Shifa, Delhi, ynm; pp:1290-1291.
9. Kabiruddin M. Makzan ul Mufradat. Idara Kitab-ul-Shifa, Daryaganj, Delhi, 2007;pp: 398-399.
10. Kabiruddin M. Tarjuma-e-Nafisi. Daftar-ul- Masih, New Delhi, ynm; pp: 136.
11. Jurjani I. Zakheera Khwarzam Shahi. Volume I. Munshi Nawal Kishor, Lucknow, 1874; pp: 1434-1437, 1753-1755.
12. Krishan DV. Vedic Nighantu or Vedic Makhzan ul Mufradat. Tibbi Risala Ghar, ynm;pp:204.
13. Al Biruni. Al-Biruni’s book on Pharmacy & Materia Medica. Edited & English translated by said M. Hamdard foundation. Karachi. Pakistan; PP:127-128.Krishan DV. ynm. Vedic Nighantu or Vedic Makhzan ul Mufradat. Tibbi Risala Ghar, 1973;pp: 237-238.
14. Ibn Baitar. Al Jamai-ul-Mufradat al Advia al Aghzia. Volume II. Central Council for Research in Unani Medicine. New Delhi, ynm; pp: 133-135.
15. Ghulam N. Makzan ul Mufradat wa Murrakkabat. Central Council for Research in Unani Medicine. New Delhi, 2007;pp:134.
16. Kirtikar & Basu. Indian Medicinal Plants. Volume 1. International Book Distributors, Dehradun, 2005;pp: 700-701.
17. Fazalullah. Makzan ul Mufradat Maroof ba Khawas ul Advia. Matba Noor Mohammad, Lucknow, ynm;pp: 238.
18. Raghunathan K and Mitra R(Eds). Pharmacognosy of Indigenous Drugs. Volume II. Central Council for Research in Ayurveda and Siddha, New Delhi, 1982; pp: 654-666.
19. Chatterjee A and Pakrashi SC (Eds). The Treatise on Indian Medicinal Plants.Volume II. Publications and Information Directorate. New Delhi, 1992; pp: 125-126.
20. Ibn Sina. Al-Qanoon fit Tibb. Volume 2. Idara kitab us shifa. New Delhi, 2007; pp.: 106.
21. Baghdadi. Kitab al Makhtarat- e-Fit Tib. Volume II. Central Council for Research in Unani Medicine. New Delhi, 2005; pp: 186-187.
22. Khare CP. Encyclopaedia of Indian Medicinal Plants. Springr India Private limited Barakhamba Road. New Delhi, 2004; pp: 459-460.
23. Khan HA. Majmul Bahrain.Munshi Nawal Kishore, Lucknow, 1874; pp.143.
24. Kapoor LD. Handbook of Ayurvedic Medicinal Plants. CRC Press, Taylor & Francis Group. Boca Raton London; PP: 327-329.
25. Anonymous. The Ayurvedic Pharmacopoeia of India. Part I. Volume II. Ministry of Health and Family Welfare. New Delhi, 1999; pp: 114-115.
26. Latafat T, Siddqui MMH, Jafri SAH. A clinical study of Marham Dakhliyoon on Chronic Cervicitis Erosion. Ancient science of Life, 1992; XI (3 & 4):158-162.
27. Sumayya AR, Srinivasan S, Amatullah N. Screening and Biochemical Quantification of Phytochemicals in Fenugreek (Trigonella foenum-graecum).Research Journal of Pharmaceutical, Biological and Chemical Sciences, 2012; 3(1):165-169.
28. Karawya MS, Wassel GM, Baghdadi HH, Ammar NM. Mucilaginous Contents of Certain Egyptian Plants. Planta Medica, 1980; 38(1): 73-78.
29. Pundarikakshudu K, Shah DH, Panchal AH, Bhavsar GC. Anti-inflammatory Activity of Fenugreek (Trigonella foenum-graecum Linn) Seed Petroleum Ether Extract. Indian Journal of Pharmacology, 2016; 48 (4):441-444.
30. Atila Vijayalakshmi K, Mishra SD, Prasad SK. Nematicidal Properties of Some Indigenous Plant Materials against Second Stage Juveniles of Meloidogyne incognita (Koffoid and white) Chitwood. Indian Journal of Ent, 1979; 41:326.
31. Genet S, Kate RK, Baquer NZ. Effects of Vanadate, Insulin and Fenugreek (Trigonella foenum graecum) on Creatine kinase in Tissues of Diabetic Rat. Indian Journal of Experimental Biology, 1999; 37:200-202.
32. Kamal R, Yadav R, Sharma JD. Efficacy of the Steroidal Fraction of Fenugreek Seed Extract on Fertility of Male Albino Rats, Phytother Res, 1993;7(2), 134-138.
33. Kamal R, Sharma JD, Mathur L. Contraceptive Efficacy of Steroidal Extract of Fenugreek on Male Albino Rats: EM Withdrawal Symptoms and Bioassay, In: The 41st Annual Meeting of the American Society of Pharmacognosy, 2000; pp: 1-16.
34. Khosla P, Gupta DD and Nagpal RK. Short Communication Effect of Trigonella foenum graecum (Fenugreek) on Blood Glucose in Normal and Diabetic Rats. Indian Journal Physiology and Pharmacology, 1995; 39(2): 173-174.
35. Khosla P, Gupta DD and Nagpal RK. Effect of Trigonella foenum graecum (Fenugreek) on Serum Lipids in Normal and Diabetic Rats. Indian Journal of Pharmacology, 1995; 27(2): 89-93
36. Losso JN. Holliday DL, Finley JW, Martin RJ, Rood JC, Yu Y, Greenway FL Fenugreek Bread: A Treatment for Diabetes Mellitus. Journal of Medicinal Food, 2009;12(5): 1046-49.
37. Pawar VS and Hugar S. Adaptogenic Activity of Trigonella foenum graecum(Linn) Seeds in Rodents Exposed to Anoxia and Immobilization Stress. Asian Pecific Journal of Tropical Biomedicine, 2012: S208-2011.
38. Subhashini N, Thangathirupathi A, Lavanya N. Antioxidant Activity of Trigonella Foenum Graecum using various in Vitro and Ex Vivo Models.International Journal of Pharmacy and Pharmaceutical Sciences, 2011;3 (2):96-102.
39. Akter Moli, Mirola Afroze, Ambia Khatun. Evaluation of Analgesic, Neuropharmacological and Cytotoxic Activity of Trigonella foenum-graecum Linn. International Current Pharmaceutical Journal, 2011; 1(1):6-11.
40. Sreeja S, Anju V.S. & S. Sreeja. In vitro Estrogenic Activities of Fenugreek Trigonella foenum graecum Seeds. Indian Journal of Medical Research, 2010; 131:814-819.
41. Mohammadi A, Gholamhosseinian A., Fallah H. Trigonella foenumgraecum Water Extract Improves Insulin Sensitivity and Stimulates PPAR and γ Gene Expression in High Fructose-Fed Insulin-Resistent Rats. Journal of Advanced Medical Research, 2016; 5: 54.
42. Chatterjee S, Prasad S, Variyar, Sharma A. Bioactive Lipid Constituents of a Fenugreek. Food Chemistry, 2010; 119(1): 349-353.
43. Frias J, Martinaez-Villaluenga C, Gulewicz P, Perez-Romero A, Pilarski R, Gulewicz K, Vidal-Valverde C. Biogenic Amines and HL60 Citotoxicity of Alfalfa and Fenugreek Sprouts. Food Chemistry, 2007; 105(3):959-967.
44. Suja PR, Anuradha CV, and Viswanathan P. Gastroprotective effect of fenugreek seeds (Trigonella foenum graecum) on experimental gastric ulcer in rats. J Ethnopharmacol, 2002; 8: 393-397.
45. Meera R, Devi P, Kameswari B, Madhumitha B & Merlin NJ. Antioxidant and Hepatoprotective Activities of Ocimum basilicum Linn. & T. foenum –graecum Linn. against H2O2 and CCL4 induced Hepatotoxicity in Goat Liver. Indian Journal of Experimental Biology, 2009; 47: 584-590.
46. Kole PL,Jadhav HR,Thakurdesai P and Nagappa AN. Cosmetics Potential of Herbal Extracts. Journal of Natural Product Radiance, 2005; 4(4): 318.
47. Megha D, Anissa M, Balkrishna U, Rohini K, (2012). Effect of Trigonellafoenum-graecum (Fenugreek/ Methi) on Hemoglobin Levels in Females of Child Bearing Age. Biomedical Research; 23 (1): 47-50.
48. Elizabeth S, Amanda R and Luis V. Physiological Aspects of Male Libido Enhanced by Standardized Trigonella foenum-graecum Extract and Mineral Formulation. Phytotherapy Research, 2011; 25(9):1294-1300.
49. Yaheya M and Ismail M. Evaluation of Antidiabetic Activity of Trigonella Seeds and Aegle marmelos Leaves. World Applied Sciences Journal, 2009; 7(10): 1231-1234.
50. Prasanna M. Hypolipidemic Effect of Fenugreek: A Clinical Study. Indian Journal of Pharmacology, 2000; 32:34-36.
51. Kruse FC, Ellen N and Helene N. Allergenicity and Antigenicity of Fenugreek. Journal of Allergy Clinic Immunology, 2009;123(1): 187-194.
52. Verma S,Kumar N and Sharma PK. Extraction and Evaluation of Trigonella foenum graecum Linn & Linum usitatissimum seed mucilage. Global Journal of Pharmacology, 2014; 8(4): 510-514.
53. Kumar R, Patil S , Patil MB, Sachin R. Patil SR, Paschapur MS. Isolation and Evaluation of Disintegrant Properties of Fenugreek Seed Mucilage. International Journal of Pharm Tech Research CODEN (USA), 2009;1(4):982-996.