Welcome Dr. Lia Ginaldi to International Journal of Aging Research

Dr. Lia Ginaldi
Full Professor
Department of Clinical Medicine, Public Health, Life and Environment Sciences University of L’Aquila


Biography & Research Interest

Welcome Dr. Lia Ginaldi to Join the Editorial Board of International Journal of Aging Research.

Memberships
– Italian Society of Allergology, Asthma and Clinical Immunology (SIAAIC) 1986
– Italian Society of Immunology and Immunopathology (SIII) 1987
– National Association Against AIDS (ANLAIDS) 1994
– American Association for Cancer Research (AACR) 1995
– American Society of Clinical Oncology (ASCO) 1996
– Italian Society of Internal Medicine (SIMI) 2004
– College of Internal Medicine Professors (COLMED 09) 2004
– Italian Group for Chronic Inflammatory Diseases (Gimicron) 2010
– National Research Center for Gender Health and Medicine 2011
– International Society for Gender Medicine (IGM) 2011
– Italian Society of Osteoporosis, Mineral Metabolism and Skeletal Diseases (SIOMMS) 2011
– Founding Member of the Italian Society of Health Professions 2018
Delegate of the Associate Professors of L’Aquila University at the COLMED 2004-2007
Board Member of the SIAAIC (Lazio-Abruzzo section) 2009-2014
Founding Member and President of Interamnia Gender Medicine Association 2016-2017

Scientific Reviewer for Research Projects
2001: Austrian K-plus Project for a Center of Excellence on Age-related Diseases and Technologies;
2006: Research into Ageing, London
2010: Welcome Trust Project-University Award, Populations and Public Health, London
2014: Scientific Independence of young Researchers (SIR) Research Projects of the Italian Ministry of Education, University and Research
2014: ”Research Projects” Call for Proposals of the Croatian Science Foundation. Croatian Science Foundation (HRZZ)
2015: Research Lines of Excellence at National Research Institutes of Health−Spain

CLINICAL ACTIVITY
Clinical activity has progressively been developed in the management of onco-hematologic, immunologic, rheumatologic and allergologic patients.
From 1983 to 1992 she attended the Unit of Internal Medicine II of L’Aquila University, at the Teramo Hospital, where actively participated in the care of hospitalized patients, particularly focusing on onco-hematology diagnostics.
1987-2000 Clinical activity in favor of HIV-positive patients in Teramo jail, according to a specific agreement signed with the Ministry of Grace and Justice, in collaboration with the Department of Infectious Diseases of Teramo Hospital, for the diagnosis and treatment of AIDS.
1992-2004 Assistant Professor and head of Cytoimmunology Service at the Division of Internal Medicine II, where conducted clinical trials involving various oncohematologic pathologies and actively participated in epidemiological and clinical control of HIV infection.
2004-2007 Head of the Immunological Physiopathology unit (UOSD), including an immunology laboratory, an outpatient clinic and a day hospital service of immuno-allergology and internal medicine, which functions as a Reference Center for Immunological Pathologies within the Department of Medicine and Medical Specialties, as Center authorized by regional decree to diagnose and treat rheumatic diseases with “biological” drugs and Interdepartmental Center for the multidisciplinary management of Osteoporosis.
2007-2018 Director of the Allergology and Immunology Unit (in Teramo) instituted at the hospital of Teramo, headquarter of the School of Specialization in Allergology and Clinical Immunology of the University of L’Aquila, Regional Reference Center for the Study and Treatment of Osteoporosis, Reference Center for Celiac Disease in Adult, Center for prescribing self-injectable epinephrine for allergic patients at risk of anaphylactic shock, and biologics in rheumatic patients, including a Percutaneous Angioscopic Outpatient Service, and Center of a project on Gender Medicine.
Current allergological and immunological care predominantly targeted to clinical, laboratory and instrumental diagnosis, biological therapy and follow up of patients with atopia and hypersensitivity to inhalants, foods and drugs, systemic autoimmunity, osteoporosis and lymphoproliferative disorders.

Scientific Research Activity
Research lines in the field of medical techniques essentially applied to immunological diagnosis and pathophysiological mechanisms of immune system diseases with clinical and translational implications.
Scientific experiences in foreign research institutes (The Academic Department of Haematology and Cytogenetics and the Institute of Cancer Research – Royal Marsden Hospital – London and The Center for Research and Education on Aging (CREA) – University of California – Berkeley) led to the definition of innovative techniques for the study of the immunological profile in chronic inflammatory diseases and elderly and neoplastic patients. Moreover, the results of these studies, aimed at precision medicine, had clinical applications in the target therapy of lymphoid leukemias (anti-CD52 MoAb biological therapy).
Later, as Director of the School of Specialization in Allergology and Clinical Immunology of L’Aquila University and Director of the Allergy and Immunology Unit of Teramo Hospital, the scientific activity addressed the application of laboratory and instrumental techniques to the study of patients with allergic, autoimmune and inflammatory diseases, mainly in aging (osteoporosis) and immunodeficiency conditions (HIV infection). Acquisitions in this field allowed a new reading of the shared inflammatory background observed in such pathologies, whose practical implications may provide useful diagnostic tools and innovative therapies.

Main research lines:
Multiparametric and quantitative flow cytometry techniques applied to the study of phenotype and antigen modulation of lymphocyte subpopulations in physiologic, reactive and neoplastic conditions.
Study of the applicability of such analytical methods in the differential diagnosis and follow up of chronic lymphoproliferative disorders, immunodeficiency syndromes and age-related immune pathologies; the identification of membrane molecules to be used as potential targets for monoclonal antibody therapy; the selection of patients for biological treatments.
Detection and quantification of cytokines, adhesion molecules and activation receptor expression applied to the study of immune system remodeling in chronic inflammation, focused on the understanding of the major risk factors, developmental mechanisms and clinical manifestations of aging, allergiy and autoimmunity.
Identification of peculiar functional immune profiles shared by these pathological conditions and their correlation with clinical and prognostic aspects, targeted to a more appropriate multidisciplinary and personalized clinical approach.
Analysis of skeletal remodeling in pathophysiological conditions, using computerized bone mineralometry techniques, as tool for early diagnosis and identification of patients at greater osteoporotic risk on which to plan targeted prevention and therapy interventions.
Development of methods for the analysis of splenic and intestinal function, with clinical application in the differential diagnosis of food intolerances, malabsorption syndromes and allergies.
Identification, using methods evaluating both hemocatheretic and immune activity, of a condition of hyposplenism and tuftsin deficiency in HIV seropositive patients, which contributes to their severe immunodeficiency.
Demonstration, by gas-chromatography on the exhaled, of a condition of food intolerance and carbohydrate malabsorption in HIV infection, contributing to the progressive cachexia observed in such condition.
The results of these research lines and their translational implications have been the subject of Publications (research articles, opinion papers and reviews) and presentations at National and International Meetings and Training Courses.


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