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SYNTHETIC MOLECULES APPLIED IN THE TREATMENT OF TYPE 2 DIABETES

Review Article of International Research Journal of Diabetes and Metabolism Synthetic molecules applied in the treatment of type 2 diabetes João Alberto Lins de Lima1, 2, Rafael Artur Queiroz Cavalcanti de Sá3, Viviane Ramos Bandeira3, Francisco Henrique da Silva3, Matheus Alves Siqueira de Assunção4, Fálba Bernadete Ramos dos Anjos4, Bárbara de Azevedo Ramos2 1Departent of Chemistry, Rural Federal University of Pernambuco; 2Department of Antibiotics, Federal University of Pernambuco,  Recife, Pernambuco, Brazil; 3Department of Biochemistry, Federal University of Pernambuco,  Recife, Pernambuco, Brazil; 4Department of Histology and Embryology, Federal University of Pernambuco,  Recife, Pernambuco, Brazil Diabetes is considered a multifactorial disease that afflicts populations of the most diverse classes worldwide, being among the main health problems today. Among the types of diabetes, type 2 diabetes mellitus (DM-2) is considered the most prevalent pathology. This is due to the direct relationship between the cause of this disease and people’s eating behavior. These factors justify the growing search for the development of drugs for DM-2, given that current drugs act on targets that are not very efficient for the treatment. Therefore, the objective of this review is to evaluate the progress of research related to the search for new synthetic drugs for a more selective treatment for DM-2. The researches were searched in the main academic databases (National Center for Biotechnology Information (NCBI), Science Direct and Google Scholar), and research tools such as Drug Bank and Clinical Trials. Seventy articles were selected that were causally related to the descriptors used. According to the survey, about 60 compounds of synthetic origin were found and present in the various phases of the study and some molecules already approved for use. A variety of strategies and new therapies related to DM-2 grows each year, as new targets involved are elucidated. Therefore, it is possible to envision a ...

Use of medicinal plants in the diabetes treatment

Review Article of Journal of Herbal Medicine Research Use of medicinal plants in the diabetes treatment Aparecido Jonanthan Mandú de Araújo1,2, Amanda Virgínia Barbosa2, Francisco Henrique da Silva1, Rafael Artur Queiroz Cavalcanti de Sá2, Sivoneide Maria da Silva2, Bárbara de Azevedo Ramos3, Matheus Alves Siqueira de Assunção4, Márcia Vanuza da Silva1, Maria Tereza dos Santos Correia1 1Department of Pharmacy, Federal University of Pernambuco, Recife, Pernambuco, Brazil 2Department of Biochemistry, Federal University of Pernambuco, Recife, Pernambuco, Brazil 3Department of Antibiotics, Federal University of Pernambuco,  Recife, Pernambuco, Brazil 4Department of Histology and Embryology, Federal University of Pernambuco, Recife, Pernambuco, Brazil Medicinal plants have been used by the population since the beginning as a tool to prevent and fight diseases. In addition, to strengthening local culture and offering cheaper labor, this practice is an alternative to conventional therapies. The use of these plants in metabolic disorders has been studied worldwide. It has shown promising results in reducing glycemic levels and profiles related to diabetes, such as LDL lipid profile, total cholesterol, triglycerides, and glycated hemoglobin (HbA1c). These results can be potential sources for pharmacological treatments, through the production of medicines, as well as the implementation of these plants in the diet, dispensing with the use of commercialized drugs. Keywords: Phytotherapy, diabetes, dyslipidemia ...

DIABETES CLASSIFICATION

Review Article of International Research Journal of Diabetes and Metabolism Diabetes classification Francisco Henrique da Silva1, Matheus Alves Siqueira de Assunção2, João Carlos de Oliveira Pinto1, Alamisne Gomes da Silva3, Aline Fernanda Carneiro Cardoso3, Fálba Bernadete Ramos dos Anjos2 1Department of Biochemistry, Federal University of Pernambuco, Recife, Pernambuco, Brazil 2Department of Histology and Embryology, Federal University of Pernambuco,Recife, Pernambuco, Brazil 3Pharmaceuticalpela Federal University of Pernambuco, Recife, Pernambuco, Brazil The therapeutic approach established for diabetes control varies according to its classification. Understanding the differences between each type is possible a complete and distinct treatment for the individual. This chapter will address the classification of diabetes types as well as their main differences. Keywords:  LADA, MODY, Other types of diabetes ...

Relation between pregnant women and the Brazilian Unified Health System (SUS): Screening and diagnosis of GDM

Review Article of International Research Journal of Obstetrics and Gynecology Relation between pregnant women and the Brazilian Unified Health System (SUS): Screening and diagnosis of GDM Matheus Alves Siqueira de Assunção1*, Francisco Henrique da Silva2, Aline Fernanda Carneiro Cardoso3, Evandro Valentim da Silva4, Hellencléia Pereira Cunha3, Fálba Bernadete Ramos dos Anjos2 1Department of Histology and Embryology, Federal University of Pernambuco,  Recife, Pernambuco, Brazil 2Department of Biochemistry, Federal University of Pernambuco, Recife, Pernambuco, Brazil 3Graduada em Farmácia pela Federal University of Pernambuco, Recife, Pernambuco, Brazil 4Clinical Hospital, Federal University of Pernambuco,  Recife, Pernambuco, Brazil The existence of a complex health system is capable of providing the necessary care for the mother and mother, but the levels of complexity of this treatment vary according to the need and severity of the situation in which the pregnant woman is ebcibtra. From this perspective, this chapter will address the relationship between pregnant women and the Brazilian Unified Health System, as well as the care and diagnosis of Gestational Diabetes Mellitus. Keywords: SUS, Complexity, Treatment, Diabetes ...

METABOLISM: PANCREAS AND GLYCEMIC REGULATING HORMONES

Review Article of American Journal of Anatomy and Physiology METABOLISM: PANCREAS AND GLYCEMIC REGULATING HORMONES Francisco Henrique da Silva1, Matheus Alves Siqueira de Assunção2, Alamisne Gomes da Silva3, Evandro Valentim da Silva4, Aline Fernanda Carneiro Cardoso3, Fálba BernadeteRamos dos Anjos2 1Department of Biochemistry, Federal University of Pernambuco, Recife, Pernambuco, Brazil 2Department of Histology and Embryology, Federal University of Pernambuco,  Recife, Pernambuco, Brazil 3Pharmaceutical of University of Pernambuco, Recife, Pernambuco, Brazil 4Clinical Hospital, Federal University of Pernambuco,  Recife, Pernambuco, Brazil Understanding the physiology of the metabolic regulation of hormones responsible for glycemic control is of fundamental importance for a thorough understanding of Diabetes Mellitus. In this scenario, this chapter is intended to explain this regulation, as well as the main hormones that participate in this metabolic process. Keywords: Insulin, Glucagon, Hormone Regulation ...

COVID-19 infection In Beta Thalassemia Major: Case series

Case Report of International Journal of Case Reports COVID-19 infection In Beta Thalassemia Major: Case series Lina Okar1*, Maya Aldeeb1, Rita Ahmad1, Mohamed A. Yassin2 1Department of Medical Education, Hamad Medical Corporation, Doha, Qatar. 2Department of Medical Oncology, Hematology Section, National Center for Cancer Care & Research, Hamad Medical Corporation, Doha, Qatar. COVID-19 infection was first described in Wuhan, China after an increasing spread of atypical pneumonia of unknown pathogen. Unfortunately, this novel virus continues spreading causing a pandemic. Thalassemia considered one of the most common hemoglobinopathies. Beta thalassemia is the commonest type with a variety in clinical picture due to the deference in homozygous. A lot of vulnerable categories were at high risk of getting infected with the coronavirus and more even its complication. Despite the conflicting data and ongoing research on this topic, thalassemia patients were categorized among the high-risk population. Here we present a case series describing the clinical progression of two splenectomised patients who has transfusion dependent beta thalassemia major. Keywords: COVID-19; Beta Thalassemia Major; Haemoglobinopathies; Splenectomy; blood transfusion ...