Review Article of Scientific Research and Reviews Useful concepts in magnetism, for supraconductivity and depleted uranium cleaning Florent Pirot Independent researcher This short note is of interest for depleted uranium cleaning and supraconductivity studies. It presents ways to cleanse depleted uranium efficiently. Keywords: Magnetism; Uranium cleaning; Supraconductivity studies ...
Magnetism; Uranium cleaning; Supraconductivity studies
Case Report of International Journal of Case Reports Advances in Diagnosis of Mitochondrial Diseases: Case Report of an Infant with Pearson Syndrome Lilian Cohen MD, MPH1* and Ana Maria Rodriguez Barreto MD1*, Miguel Dario Cantu MD2, Catherine McGuinn MD1, Madhu Ouseph MD, PhD2, Sanjay Patel MD, MPH2, Shipra Kaicker MD1 1Department of Pediatrics, Weill Cornell Medical College, New York Presbyterian Hospital; 2Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York Presbyterian Hospital Pearson syndrome (PS) is a mitochondrial disorder that presents in early infancy as a multisystemic disease affecting the bone marrow and pancreas. It may present with anemia, diarrhea, exocrine pancreatic dysfunction, and failure to thrive. Delay in diagnosis can lead to severe morbidity and mortality in infancy. We report the case of a 9-month-old presenting with failure to thrive, severe macrocytic anemia and pancytopenia initially thought to have gastroesophageal reflux and feeding intolerance. Severe macrocytic anemia and pancytopenia prompted an early bone marrow evaluation. Abnormal bone marrow findings including vacuolated marrow precursors and ringed sideroblasts along with persistent mild lactic acidosis led to a rapid and extensive genetics workup. Whole exome sequencing including mitochondrial genome sequencing detected a 2.3 kb heteroplasmic deletion in m.12113_14421 encompassing the MT-ND5 gene consistent with the diagnosis of Pearson Syndrome. This case report highlights the advances in molecular genetic testing to diagnose patients with complex medical histories along the spectrum of mitochondrial diseases and the importance of early diagnosis to start treatment. Abbreviations: Pearson syndrome (PS); mitochondrial DNA (mtDNA); Kearns-Sayre syndrome (KSS); Mitochondrial Encephalomyopathy, lactic acidosis and stroke-like episodes (MeLAS); Hematopoietic Stem Cells for Transplantation (HSCT), Preimplantation Genetic Testing (PGT), Human Leukocyte Antigen (HLA). Keywords: Mitochondrial disease, Pearson Syndrome, Molecular Genetic Testing, Whole Exome Sequencing, Mitochondrial DNA ...
Mitochondrial disease, Pearson Syndrome, Molecular Genetic Testing, Whole Exome Sequencing, Mitochondrial DNA.
Paleontology vs. Archaeology in the French Riviera volcanism : crystallized Permian animals and dinosaur skeletons in andesitic rocks, and human remains from the medieval times
Research Article of International Journal of Archaeological Research Paleontology vs. Archaeology in the French Riviera volcanism : crystallized Permian animals and dinosaur skeletons in andesitic rocks, and human remains from the medieval times Florent Pirot Independent researcher This letter details principles of fossilization that matter for the study of fossils in general, but with a preference for sites next to volcanic areas. Keywords: Paleontology; Archaeology; French Riviera volcanism ...
Paleontology; Archaeology; French Riviera volcanism
Research Article of American Journal of Surgical Research and Reviews New Trends In Treacher Collins Syndrome: Bony Reconstruction And Regenerative Therapy Luigi Clauser1, Chiara Gardin2, Letizia Ferroni2, Antonio Lucchi1, Carolina Sannino1, Maria Elena de Notariis1 and Barbara Zavan2 1Unit of Maxillo-Facial Surgery, Istituto Stomatologico Italiano, Via Pace, 21, 20122 Milano, Italy; 2 Department of Biomedical Sciences, University of Padova, 35100 Padova, Italy Aim:Treacher Collins syndrome is a rare congenital disorder of craniofacial development with a highly variable pheonotype. This syndrome occurs with an incidence of 1:50,000, and more than 60% of the cases have no previous family history and arise as the result of de novo mutations. The disorder displays an intricate underlying dysmorphology. Affected patients may suffer life-threatening airway complications and functional difficulties involving sight, hearing, speech, and feeding. Deformation of facial structures produces a characteristic appearance that includes malar-zygomatic hypoplasia, periorbital soft tissue anomalies, maxillomandibular hypoplasia, and ear anomalies. Management requires a specialized craniofacial team, as comprehensive care starts at birth and may require life-long follow-up. Standard craniofacial procedures for bony and soft tissue reconstruction are used. This article outlines current treatment strategies and future concepts for surgical and regenerative management. Methods:The new field of regenerative medicine and therapy offers the promise to improve some of these treatments. In particular, Structural Fat Grafting (lipostructure) seems to be a good strategy to restore the normal volume and contour of the face, and to provide a source of adipose-derived stem cells (ADSCs) with a multilineage differentiation potential. In this work, we present the case of a young girl with Treacher Collins Syndrome who underwent serial sessions of fat grafting in addition to other surgical bony reconstructive techniques. ADSCs have been isolated from the patient’s lipoaspirate, and compared for their stemness properties with those of a healthy subject. Conclusion:Screening of the ...
Craniofacial surgery,Treacher Collins syndrome, regenerative medicine, structural fat grafting, adipose-derived stem cells, gene expression; array-CGH,tissue engineering
Review Article of International Research Journal of Public Health Behind transgender identities – the biophysics & the societal deficits creating the phenomenon Florent Pirot Unaffiliated researcher Transgender identities, with or without surgical changes are produced by individual decisions which resonate nevertheless with a series of information deficits and also spill from the biophysical effects of artificial sources of contamination. Findings from other researchers and the author's experience are brought together to prove the point. Keywords: Behind transgender identities ; biophysics; societal deficits; phenomenon ...
Behind transgender identities ; biophysics; societal deficits; phenomenon
COMPARISON OF THE EFFICACY OF SUBCISION WITH FRACTIONAL CARBON DIOXIDE LASER VERSUS SUBCISION WITH MICRONEEDLING FRACTIONAL RADIOFREQUENCY IN THE TREATMENT OF ATROPHIC POST ACNE SCARS
Research Article of American Journal of Dermatological Research and Reviews Comparison of the efficacy of Subcision with Fractional Carbon Dioxide Laser versus Subcision with Microneedling Fractional Radiofrequency in the Treatment of Atrophic Post acne Scars Nabeel K. Al-Hamzawi Department of Dermatology, Al-Diwaniyah Teaching Hospital, Diwaniyah, Iraq Background: Many interventions have been used to treat post-acne scars, with various degrees of efficacy and adverse reactions. Multimodal approach can achieve better results for improving the physical appearance that even if minor may result in significant distress and reduced quality of life. Objective: To compare the efficacy of subcision with fractional carbon dioxide (CO2) laser and subcision with microneedling fractional radiofrequency (RF) in treating post-acne scars and to study their adverse effects. Methods: In this prospective, interventional clinical study, a total of 64 patients with post-acne scars were enrolled. The patients were randomly allocated into two groups of 32 patients each, in which group A was treated with subcision plus fractional carbon dioxide laser (CO2) and group B was treated with subcision plus microneedling fractional radiofrequency (RF) every 6 weeks for a total of four sittings. An objective score was calculated for each patient using the Goodman and Baron scale to evaluate the outcome every visit during treatment and then 3 months after completion of therapy. Results: In group A, the percentage reduction in the mean objective scores was found to be 64%. In group B, the percentage reduction in mean objective scores was found to be 42%. Most of the changes were seen in the boxcar and rolling types of scars. Conclusions: Subcision and fractional CO2 laser were considered superior over subcision with microneedling fractional (RF) technique for the treatment of post-acne scars. Boxcar and rolling types of scars showed a high response to treatment than icepick scars Keywords: Acne scar, Fractional ...
Acne scar, Fractional carbon dioxide laser, Microneedling, Fractional Radiofrequency Introduction