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HPV-Negative Vulvar Squamous Cell Carcinoma in a 21-year-old Patient

Review Article of International Research Journal of Obstetrics and Gynecology HPV-Negative Vulvar Squamous Cell Carcinoma in a 21-year-old Patient Dânia Ferreira1*, Paulina Corgo2, Vanda Patrício3, Amelia de Almeida4 1Hospital de Braga. 2Centro Hospitalar Medio Ave, Famalicão. 3Instituto Português de Oncologia do Porto. 4Centro Hospitalar Medio Ave, Famalicão. Vulvar Squamous Cell Carcinoma usually occurs among women in their 60s or 70s. There are a limited number of reports of vulvar cancer cases younger than 30 years. These patients have usually risk factors such as human papillomavirus (HPV) infection. In this report, the authors present a rare case of invasive vulvar squamous cell carcinoma in a 21-year-old patient without HPV infection. Surgical treatment was performed, followed by adjuvant radiation therapy. Keywords: HPV; Vulvar Squamous Cell Carcinoma ...

In-vitro Antioxidant Capacities and Genetic Classification of Indonesian Selected Pigmented Rice

Research Article of American Journal of Agricultural Research In-vitro Antioxidant Capacities and Genetic Classification of Indonesian Selected Pigmented Rice Erlin Susilowati1, Addieni Zulfa Karimah1, Sandy Pradipta2, Bella Rhea Lavifa Sanjaya2, Mohammad Ubaidillah1,2,3, Tri Agus Siswoyo1,2,3* 1Graduate School of Biotechnology, University of Jember, Jember-68121, Indonesia. 2The Center of Excellence on Crop Industrial Biotechnology (PUI-PT BioTIn), University of Jember, Jember-68121, Indonesia. 3Faculty of Agriculture, University of Jember, Jember 68121, Indonesia Rice is a world-famous cereal food divided into pigmented and non-pigmented rice. Pigmented rice is popular as healthier food than non-pigmented rice due to its potency as an antioxidant. Nevertheless, the potential of pigmented rice has not been widely studied. Indonesian selected pigmented rice protein’s antioxidant potential and the non-protein compound were in-vitro studied. The antioxidant potencies were evaluated by extracting fresh seeds of nine pigmented rice (Aek Sibundong, Beureum Taleus, Gogo Niti-2, Lamongan-1, Merah SP, Merah Wangi, Mota, Ketan Hitam-2, and Super Manggis) and non-pigmented rice (IR-64) as control. Various free radical scavenging methods to determine the antioxidant activity (ABTS•+, DPPH•, OH• and O2-) were conducted. Meanwhile, the genetic classification was performed by a simple sequence repeat (SSR) marker to determine the relationship between varieties. The results showed that protein of Ketan Hitam-2 had the highest ABTS•+ radical scavenging (98.06%), followed by Beureum Taleus (42.54%). Ketan Hitam-2 protein also showed the highest OH• and O2- activities (43.49% and 6.02%, respectively). The highest DPPH• potency of the non-protein compounds also shown by Ketan Hitam-2 (32.23%) with the activity of OH• and O2- (20.63% and 14.56%, respectively). These results showed that Ketan Hitam-2 has the highest potency as an antioxidant, which could be recommended as a nutraceuticals compound. Keywords: Antioxidant; Pigmented rice; SSR marker ...

METASTATIC TUMORS TO THE ORAL CAVITY – A RETROSPECTIVE ANALYSIS

Review Article of International Research Journal of Otolaryngology Metastatic tumors to the oral cavity - A retrospective analysis Konstantinos Paraskevopoulos1*, Konstantinos Vahtsevanos2, Aris Ntomouchtsis3, Ioanna Kalaitsidou4, Anna Patrikidou5, Charalampos Andreadis6, Konstantinos Antoniades7 1PhD, Consultant, Department of Oral and Maxillofacial Surgery, G. Papanikolaou General Hospital, Thessaloniki, Greece. 2PhD, Ass Professor, Department of Oral and Maxillofacial Surgery, G. Papanikolaou General Hospital, Thessaloniki, Greece. 3PhD, Private OMF Surgeon, Lucerne, Switzerland. 4Consultant, Department of Oral and Maxillofacial Surgery, G. Papanikolaou General Hospital, Thessaloniki, Greece. 5PhD, Consultant, Department of Oncology, Geneva University Hospital, Geneva, Switzerland. 6PhD, Director, Third Department of Oncology, Theageneion Anticancer Hospital, Thessaloniki, Greece. 7PhD, Professor, Department of Oral and Maxillofacial Surgery, G. Papanikolaou General Hospital, Thessaloniki, Greece. Objectives: Metastatic tumors to the oral cavity are observed extremely rarely, accounting for approximately 1% of all malignant oral lesions. The purpose of our study is to record and analyze the data of the patients who revealed metastasis to the oral cavity. Material and Methods: The records of the patients diagnosed with oral metastases who were admitted to Oral and Maxillofacial Surgery Departments from 1996 to 2018 were reviewed and analyzed for demographic data and outcomes. Results: Over a period of 22 years (from 1996 to 2018), 22 patients were admitted to the Oral and Maxillofacial Surgery Departments of General Hospital G. Papanikolaou and Theageneion Anticancer Hospital with oral metastasic tumors from a distant primary site. Conclusions: Metastasis to the oral cavity is a very rare finding but it exists so we have to be aware of it and have in mind the possibility of this condition. Keywords: Metastatic tumors; Oral cavity; Primary site ...

ASSESSMENT OF EFFICACY AND TOLERABILITY OF FRACTIONAL CO2 LASER IN THE TREATMENT OF AXILLARY HYPERPIGMENTATION

Research Article of American Journal of Dermatological Research and Reviews Assessment of efficacy and tolerability of fractional CO2 laser in the treatment of axillary hyperpigmentation Nevine A. Dorgham, Dina A. Dorgham Dermatology Department, Kasr Al Ainy Hospital, Cairo University,Egypt Background: Axillary hyperpigmentation is a common and troublesome complaint especially among dark-skinned women. It is believed to be a form of post-inflammatory hyperpigmentation and so far, there is no universally accepted treatment for the disorder. Objective: The aim of this study is to assess the efficacy of fractional CO2 laser in the treatment of axillary hyperpigmentation Patients and methods: Thirty Egyptian females with axillary hyperpigmentation were recruited. The severity of the condition was estimated by both self-assessment and expert dermatologist before treatment. Four sessions of fractional CO2 laser were done. Both the efficacy and complications were assessed by the patient and the dermatologist six month after the last session. Results: There was a statistically significant difference of percentage of improvement of pigmentation before compared to one month after treatment as detected by self-assessment (p value= 0.002) and the observer’s assessment (p value= 0.001). Conclusion: Fractional CO2 laser, in properly chosen parameters, is an effective method for the treatment of axillary hyperpigmentation. Keywords: Axillary hyperpigmentation, fractional CO2 laser ...

COMBINING 308-MONOCHROMATIC EXCIMER PHOTOTHERAPY WITH MONTHLY IM TRIAMCINOLONE ACETONIDE FOR THE TREATMENT OF RESISTANT ALOPECIA TOTALIS

Research Article of American Journal of Dermatological Research and Reviews Combining 308-monochromatic excimer phototherapy with monthly IM triamcinolone acetonide for the treatment of resistant alopecia totalis Nabeel K. Alhamzawi Department of Dermatology, Diwaniyah Teaching Hospital, Diwaniyah, Iraq Background:   Treatment of resistant alopecia totalis AT is a major problem in general practice.  Some studies reported the use of either excimer-308 or intra-muscular triamcinolone acetonide as a monotherapy, with conflicting results. Objective: To evaluate the therapeutic effect of combining 308-excimer phototherapy and intramuscular triamcinolone acetonide for the treatment of alopecia totalis. Methods and Material: Ten patients with alopecia totalis were evaluated in this prospective interventional study. All patients were assigned to receive the thera-peutic regimen that includes monthly IM triamcinolone acetonide (TAC) for a maximum of six pulses and twice-weekly excimer phototherapy for 24 sessions. Results:  The overall response rate for this regimen was 90%, with four patients 40% achieving complete regrowth of hair (100%). Three patients have exhibited a satisfactory response (>70% regrowth). Unsatisfactory response ( >10-< 70% regrowth) was reported in two patients . Younger patients responded better, as did those with a shorter history of the disease P < 0.05.  At follow-up, which continued for 8–12 months, recurrence was noted in two (22.2%) of the nine responders. Conclusions:  Combining excimer phototherapy with triamcinolone acetonide showed a promising effect on resistant AT. This treatment modality was effective and well tolerated particularly in young patients. Keywords: Alopecia totalis, excimer light, Triamcinolone acetonide, Combined treatment ...

RELATIONSHIP BETWEEN PERONEAL TENDONS AND ANTERIOR TALOFIBULAR LIGAMENT

Research Article of American Journal of Orthopedic Research and Reviews Relationship Between Peroneal Tendons and Anterior Talofibular Ligament Ahmet Oztermeli, Nazım Karahan Gebze Fatih State Hospital, Corlu State Hospital Background: Anterior talofibular ligament (ATFL) injuries are the most common in ankle torsional injuries. ATFL and peroneal tendons are both important stabilizers of lateral ankle joint. We aimed to evaluate peroneal tendons and ATFL. Methods: Fifteen nonpaired leg of fresh frozen cadavers were assessed in this study. After harvesting, ATFL diameters were measured at three points by calipers, these are fibular side, intermediate side and talar side. The mean of these three measurements were assessed and tissue a 15 lb load was applied to the peroneal tendons for 10 minutes, and the transverse diameters were measured by folding the thickest part of the tendon in a double-strand. Results: 5 single bundle, 8 double-bundle and 2 three bundles of ATFL were obtained after dissection. . There was no correlation between ATFL diameter, peroneus longus, peroneus brevis and total tendon diameters of peroneus longus and peroneus brevis in women (p> 0.05). A strong correlation was found between ATFL diameter, peroneus longus (r: 0.95), peroneus brevis (r: 0.81) and total tendon diameters of peroneus longus and peroneus brevis (r: 0.92) in men. Conclusion: Relationship between the diameter of the ATFL and peroneal tendons diameters were evaluated and a correlation was observed in males, while no correlation was observed in females. Keywords: Anterior talofibular ligament; Peroneal tendons; Ankle sprain; Peroneus longus; Peroneus brevis; Cadaveric study ...