The Role of Maternal Stress, Cortisol and Interleukin-12 in Cases of Missed Abortion in the First Trimester of Pregnancy in Saudi Women

The Role of Maternal Stress, Cortisol and Interleukin-12 in Cases of Missed Abortion in the First Trimester of Pregnancy in Saudi Women

Khulood S. Husseina*

aDepartment of Physiology, Faculty of Medicine, King Abdulaziz University, Jeddah, KSA

American Journal of Anatomy and Physiology 2D

Missed abortion in early pregnancy is a common gynecological condition, and the incidence has been increasing presenting itself as a public health problem. This study aimed to examine stress, cortisol concentration, and altered IL-12 levels in women who experienced missed abortions. Women with missed abortions (n = 40) were matched with control women of the same age in the same stage of pregnancy (n = 30). Participants filled out a survey about common stress factors. Venous blood samples were taken from the patients at 7:00 a.m. ELISA detected IL-12 concentrations, and serum cortisol was measured by electrochemiluminescence immunoassay. Women with missed abortions reported significantly more common stressors, and their serum cortisol and IL-12 concentrations were significantly higher than those of the women with healthy pregnancies (all P< 0.05). Receiver operating characteristic (ROC) analysis was used to assess the power of the studied parameters to predict women at risk for missed abortion. IL-12 performed the best in predicting women with missed abortions as it had the highest area under the curve (AUC), followed by cortisol. Stress and changes in the immune system may play a role in the etiology of missed abortion in Saudi women in early pregnancy.

Keywords: Stress marker, Cortisol, IL-12, Missed abortion, Saudi women, Early pregnancy.

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How to cite this article:
Khulood S. Hussein. The Role of Maternal Stress, Cortisol and Interleukin-12 in Cases of Missed Abortion in the First Trimester of Pregnancy in Saudi Women. Hussein.American Journal of Anatomy and Physiology, 2019, 2:6


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