Patulin Induced Dominant Lethal Gene in Mature Male and/or Female Rats

Patulin Induced Dominant Lethal Gene in Mature Male and/or Female Rats

Fawzyea abdelhady zaied1; Mohamed Abd Elsalam Rashed2; Sabha Elsayed Elballat1*and Hassanat Elsayed Ali1

1Zoology Department, Faculty of Science, Zagazig University, Zagazig, Egypt.
2Genetic Department, Faculty of Agriculture , Ain Shames Univeristy, Cairo, Egypt.

American journal of genetics

Many fungi including Penicillium and Aspergillus species produces patulin in the contaminated foods. Patulin is a heterocyclic unsaturated lactone that reacts with SH group of biological molecules causing harmful effects in human and animal tissues. Hence, the present investigation was designed to evaluate the possible teratogenic effect of patulin (0.002mg/kg b. wt) which was examined through the induction of dominant lethal gene and the alteration in number of live births in the female rats . Results and Conclusion: patulin is a dangerous teratogen in rats. This was confirmed by the significant increase in the percentage of maternal and embryo toxicities.

Keywords: Patulin, Pregnant rats; Dominant lethal gene ; Mycotoxins; Fetal resorption ;Defective embryo; Teratogenicity .

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Fawzyea abdelhady zaied; Mohamed Abd Elsalam Rashed; Sabha Elsayed Elballat and Hassanat Elsayed Ali. Patulin Induced Dominant Lethal Gene in Mature Male and/or Female Rats. American Journal of Genetics, 2019, 2:6. DOI: 10.28933/ajg-2019-06-1105


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