The validity of Protein S 100B in Mild Pediatric Head Trauma

Magdy A. Lolah1#, Khaled A. Khalifa2, Tarek M. E. Rageh3,  Adel Hamed Elbaih4#, Mohamed A. Hussein5, Mai T. B. Meshhal6

1Department of General Surgery, Faculty of Medicine, Menoufia University, Egypt
2Department of Clinical Pathology, Faculty of Medicine, Menoufia University, Egypt
3Department of General Surgery, Faculty of Medicine, Menoufia University, Egypt
4Department of Emergency Medicine, Faculty of Medicine, Suez Canal University, Ismailia, Egypt, and Sulaiman Al-Rajhi University, Clinical Medical Science, Saudi Arabia
5Department of Neurosurgery, Faculty of Medicine, Menoufia University, Egypt
6*Department of Emergency medicine, Faculty of Medicine, Menoufia University, Egypt
#Equal contribution

Background; S100B has been shown to be beneficial as a biomarker in the treatment of adults with mild traumatic brain injury (mTBI). The efficacy of S100B as a biomarker in children, on the other hand, has been a subject of debate. Aim and objectives; was to assess the validity of Protein S 100B in Mild Pediatric Head trauma. Subjects and methods; this was a prospective study, included 160 pediatric patients with mild head trauma presented to Emergency Department. Result; A highly significant correlation between Positive S100B protein and traumatic brain injury with S100B protein value 1554.1±84.0 ng/L. A100 had cutoff value for positive CT Brain finding above 987.5 ng/L, The sensitivity was 81.0%, the specificity was 75%%, the NPV was 86%, the PPV was 68%, and overall accuracy 77%. There was none statistical significant difference regarding severity of brain injury and S100 B (P = 0.225), Conclusion; Serum S100B levels cannot be used to substitute clinical examinations or CT scans in identifying pediatric patients with mild head injuries, but they can be used to identify low-risk kids to avoid excessive radiation exposure.

Keywords: S100B, biomarker, CT Brain, mild head injuries, Pediatric.

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Magdy A. Lolah, Khaled A. Khalifa, Tarek M. E. Rageh, Abel Hamed Elbail, Mohamed A. Hussein, Mai T. B. Meshhal. The validity of Protein S 100B in Mild Pediatric Head Trauma. American Journal of Surgical Research and Reviews, 2021, 4:29. DOI:10.28933/ajsrr-2021-06-0608


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