Translational Medicine and Autologous Fat Transfer: From bench to bedside. Regenerative and proliferative potential of adipose tissue

Andrea Edoardo Bianchi, MD1,2, Antonio Lucchi, MD1, Riccardo Luoni Orsi, DMD1, Luigi Clauser, MD1

1Unit of Maxillo-Facial Surgery, Istituto Stomatologico Italiano, Via Pace, 21, 20122 MILANO, Italy; 2University UniCamillus, Via di Sant’Alessandro, 8, 00131 ROME, Italy

Aim: Autologous fat transfer (AFT) for the correction of maxillofacial defects was first reported at the end of the 19th century. AFT was introduced as a way of improving facial esthetics and in the last few years has expanded into applications in craniomaxillofacial reconstructive surgery and regenerative therapy. This protocol is part of translational medicine. The aim of translational medicine, or translational science, is to combine disciplines, resources, expertise, and techniques based on three main pillars: bench, bedside, and community. The primary goals to coalesce assets of various natures to significantly improve the global healthcare system. AFT is thus part of translational medicine in tissue healing, regeneration and augmentation.

Methods: Several techniques have been suggested for harvesting and grafting the fat. The Authors follow Coleman’s technique with centrifugation and infiltration using different types and sizes of cannulas.

Conclusion: This review provides a fairly comprehensive summary of the many exciting possibilities that exist in the field of facial fat grafting. Five clinical cases are presented and discussed. Translational medicine is the basis of this new reconstructive and regenerative field of science and research.

Keywords: Regenerative medicine, translational medicine, lipofilling, fat grafting, adipose-derived-stem-cells, fat graft survival, fat graft processing, maxillofacial surgery, soft tissue reconstruction, stem cells, bench to bedside

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Andrea Edoardo Bianchi, Antonio Lucchi, Riccardo Luoni Orsi, Luigi Clauser. Translational Medicine and Autologous Fat Transfer: From bench to bedside. Regenerative and proliferative potential of adipose tissue.American Journal of Surgical Research and Reviews, 2021, 4:33. DOI:10.28933/ajsrr-2021-08-0403


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