American Journal of Biotechnology and Bioscience


Analysis of traditional house hold alcoholic beverage to processing plant level production

Alcohol use is part of many cultural, religious and social practices, and provides perceived pleasure to many users. The aim of this project was to develop mini scale alcohol production, which would be very useful for those who focus for many developing countries including Ethiopia, developing this project have been valuable for such sector for those who had an idea to develop new alcoholic beverage project professionals. The paper tried to evaluate the economic performance of minimum level alcohol production, grow to in terms of productivity, profitability, capacity utilization, marketing and the socio-economic contribution of the project. Those, the total capital investments found from this study analysis estimated to be total 34, 673,529.41 birr and the total production cost is 4520833.3birr/yr. The Company will get a net income of 1,376,650,000 birr/year. The repayment for the investment cost will be paid off over the next 4.6 years. The project provides for efficient utilization of the existing resource, technological advancement, managerial efficiency and incentives to upgrade traditional beverages to large production process scales.

Symptoms, Gene Analysis, Diagnosis and Treatment of Neurofibromatosis type 1 (NF1) syndrome

Neurofibromatosis type 1 (NF1) is an autosomal predominant, mucocutaneous and inclination disorder. They include it in the development of benign and malignant tumors. Hereditary change in NF1 prompts changes in the outflow of cytoplasmic protein. 90% of all cases represent NF1 in neurofibromatosis. children tainted with NF1, they distinguish them inside a year.NF1 Patients ordinarily experience the ill effects of the café au laitt, freckling, and skeletal dysplasia. The GTPase actuating protein goes about as the principal job in NF1 quality, which fills in as a negative controlled by authoritative with the RAS protein. The neurofibromatosis type 1 quality is a 287-kilo premise of chromosome 17q11.2. In NF1 patients, the dermatologists distinguished the basic cutaneous highlights. Cutaneous neurofibroma has a variable pace of development during life expectancy. The threatening fringe nerve sheath tumor is plexiform neurofibromas. Palpebral plexiform neurofibroma is mono-sidelong. We have analyzed inherent dysplasia real criteria for NF1. The more exact technique to analyze NF1 in the patient is radiological indicative. An entire body MRI can test the interior nerve sheath tumor. They have announced that the research center analytic is extremely troublesome; However , it has done the RNA and ELISA tests somewhat. The treatment of NF1 patients is exceptionally troublesome because of the adequacy of the organ of the body. There is a biopsy, medical procedure, and radiotherapy performed for NF1 patients.

Affordability Issues of Biotech Drugs in low- and middle-income countries (LMICs)

As indicated by World Bank publication Disease Control Priorities: Improving Health and Reducing Poverty (third edition, 2017), about 20% all out health use universally originated from out-of-pocket payments in 2014. The equivalent was about 40% all out health use for low-income countries, 56% for lower-middle-income countries, and 30% for upper-middle-income countries (WHO, 2016). 33% of the world’s populace needs opportune access to quality-guaranteed medicines while assessments demonstrate that in any event 10% of medicine in low-and middle-income countries (LMICs) are substandard or distorted, costing roughly US$ 31 billion every year (Global Health, 2018). Shockingly, 80% of worldwide cardiovascular passings happen in LMICs which is (halfway) because of the absence of access to healthcare including talented HR, equipped offices and medicines (Global status report on noncommunicable diseases, WHO, 2010). Cost of drugs, antibodies, and diagnostics is a noteworthy weight in LMICs round the globe. Cost of biotech drugs are much higher because of surprising expense caused by the pharmaceutical organizations for clinical preliminary. Biotech drugs have totally changed the administration of a few diseases, including malignant growth and immune system diseases. Albeit essential yet their affordability is as yet a consuming issue, particularly in LMICs.

Novel urease inhibitor

Urease, also known as urea amide hydrolase, contains two metal nickel ion active centers that catalyze the decomposition of urea to ammonia and carbon dioxide. Urease is widely found in nature, including plants, animals, and microorganisms, and greatly affects the utilization of nitrogen-containing nutrients by plants and animals. At the same time, its content can also affect the normal physiological metabolism of microorganisms, which in turn affects the survival rate of microorganisms. It can be seen that the role of urease inhibitors is very important. Urease inhibitors, such substances, can affect or even inhibit the activity of urease by direct or indirect means. Guided by computer-aided drug design, the team developed two new urease inhibitors, which are low-cost, non-toxic to plants, animals and humans, and environmentally friendly urease inhibitors. After experimentally measuring the activity of urease inhibitors, the two urease inhibitors have stronger inhibition ability than the widely used acetohydroxamic acid on the market.

CYTOTOXICITY ASSESSMENT AND ANTIMICROBIAL ACTION OF Caulerpa taxifolia (M. Vahl) C.

This study aims to determine the LC50 for Artemia salina Leach and perform a microbial screening two C. taxifolia extracts. In these biological assays have been used larvae of A. salina Leach ob-tained from the incubation of about 20 mg of A. salina cysts, under artificial light for 48 hours. Where groups of 10 metanauplius were exposed to different concentrations (50 mg / mL to 1000 ug / ml) of methanol extract and hydroalcoholic C. taxifolia . The antimicrobial activity of extracts of C. taxifolia was evaluated by diffusion method in paper disc. The percentage mortality deter-mined after 24 hours of contact. Through the data was calculated LC50. Behavioral analysis of Artemia salina Leach showed a decrease in handling compared to those observed in the control groups. The microbial activity of the extracts were evaluated by measuring the halo of inhibition for two species of gram-positive and two gram-negative bacteria. The extracts showed signifi-cant results for S. aureus and S. spp. This study demonstrates that C. taxifolia has a high cyto-toxicity suggested that its use in cell culture as a molluscicide and can be used in the production of production of antimicrobial drugs.

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American Journal of Biotechnology and Bioscience

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