American Journal of Cancer Research and Reviews

Recurrent gliomas- a short review of literature.

Review Article of American Journal of Cancer Research and Reviews Recurrent gliomas- a short review of literature. Dr. Sudeb Mukherjee MBBS. MD.(Medicine), DM-Post Doctorate Fellow-ICVS, IPGME&R, Kolkata-700020. Gliomas one of the commonest tumour account for 40-60% of all primary neoplasm of the central nervous system. Very little is known about pathological changes associated with recurrence of gliomas. Histlogical changes regarding this transformation also is not well documented. Effect of radiotherapy and chemotherapy which results in decrease in cellularity, fibrosis, thickening of vessels are also not well documented. Paired study combining both primary and recurrent gliomas are sparse. Several genetic alterations has been mentioned in the causation and pathophysiology of recurrent gliomas. Starting from overexpression to mutation of p53 to Epidermal Growth Factor(EGFR), platelet derived growth factor-α(PDGF-A),PTEN , MDM2 all have mentioned several studies. This review article describes every aspects of recurrent gliomas in short span. Keywords: Recurrent gliomas, EGFR( Epidermal Growth Factor), p 53, platelet derived growth factor-α(PDGF-A) ...

Trace Element Contents in Thyroid Cancer Investigated by Energy Dispersive X-Ray Fluorescent Analysis

Research Article of American Journal of Cancer Research and Reviews Trace Element Contents in Thyroid Cancer Investigated by Energy Dispersive X-Ray Fluorescent Analysis ZAICHICK Vladimir1 and ZAICHICK Sofia2 1 Radionuclide Diagnostics Department, Medical Radiological Research Centre, Russia 2 Laboratory of Dr. Gabriela Caraveo Piso, Feinberg School of Medicine, Northwestern University, USA Background: Thyroid cancer is an internationally important health problem. The aim of this exploratory study was to evaluate whether significant changes in the thyroid tissue levels of Br, Cu, Fe, Rb, Sr, and Zn exist in the malignantly transformed thyroid. Methods: Thyroid tissue levels of six trace elements (Br, Cu, Fe, Rb, Sr, and Zn) were prospectively evaluated in 41 patients with thyroid malignant tumors and 105 healthy inhabitants. Measurements were performed using 109Cd radionuclide-induced energy-dispersive X-ray fluorescent analysis Tissue samples were divided into two portions. One was used for morphological study while the other was intended for trace element analysis. Results: It was found that contents of Br, Cu, and Rb were significantly higher (approximately 10, 3.4, and 1.4 times, respectively) and content of Zn were slightly, but significantly, lower (25%) in cancerous tissues than in normal tissues. Conclusions: There are considerable changes in trace element contents in the malignantly transformed tissue of thyroid. Keywords: Thyroid malignant tumors - Intact thyroid - Trace elements - Energy-dispersive X-ray fluorescent analysis ...

Uterine Fibroids in Senegal: Polymorphism of MED12 Gene and Correlation With Epidemiological Factors

Research Article of American Journal of Cancer Research and Reviews Uterine Fibroids in Senegal: Polymorphism of MED12 Gene and Correlation With Epidemiological Factors Kénémé Bineta1; Ciss Daouda2; Ka Sidy3; Mbaye Fatimata1; Dem Ahmadou3; Sembène Mbacké1,4 1Département de Biologie Animale, Faculté des Sciences et Techniques, Université Cheikh Anta Diop, BP 5505, Dakar, Sénégal. 2Service de Maternité et Gynécologie Obstétrique/Hôpital Général Grand Yoff. 3Institut Joliot Curie, Faculté de Médecine de Pharmacie et d’Odontologie, Université Cheikh Anta Diop, Dakar, Sénégal. 4Biologie des Populations Animales Sahélo-Soudaniennes, UMR 022, Institut de Recherche et de développement (IRD), Campus de Bel-Air, BP 1386, Dakar, CP 18524, Sénégal. Background: Mediator complex subunit 12 (MED12) is a part of the mediator complex, which is believed to regulate transcription. Our recent study showed that MED12 is mutated at high frequency and with different mutation frequencies in Senegalese women with uterine fibroids. However, the status of mutations has not been correlated to the epidemiological factors that are implicated in uterine fibroids. Methods: This study aimed to analyze status of MED12 mutations in Senegalese population. MED12 was sequenced in tumoral tissues and blood samples of 54 Senegalese women with uterine fibroids. Clinical and pathological data were obtained from the patient’s records and other parameters were recorded. Mutation Surveyor software version 5.0.1, DnaSP version 5.10, MEGA version 7.0.26 and Arlequin version were used to determine the level of mutations and genetics parameters. To estimate the genetic variation according to the epidemiological parameters, the index of genetic differentiation (Fst) and the genetic structure like analysis of molecular variance (AMOVA) were determined with Arlequin software version The significance level (P-value) was 0.05. Results: Our results showed that MED12 is mutated at 88.89% (48/54) only in tumor tissues. The variants frequencies were not similar to those found in the Finnish populations. The Chi2 test ...

Humans Papillomavirus (Hpv) Infections in Female Sex Workers in Cote D’ivoire

Research Article of American Journal of Cancer Research and Reviews Humans Papillomavirus (Hpv) Infections in Female Sex Workers in Cote D’ivoire OUATTARA Abdoulaye1, YEO Alain2, BLAVO-KOUAME E. B.2, KOFFI TCHIBEH Franck1, SARAKA NGUESSAN Daniel2, FAYE-KETTE Hortense2 and DOSSO Mireille2 1Felix Houphouet Boigny University of Abidjan. Medical Sciences School. Cote d’Ivoire 2Pasteur Institute of Cote d’Ivoire Abidjan Cote d’Ivoire Background: Human Papillomaviruses (HPV) are small virus non-enveloped double-stranded circular DNA. They infect epithelial cells (mucous membranes and skin). Many studies have indicated that having multiple sexual partners may lead to higher HPV transmission. Thus female sex workers (FSWs) may be at greater risk of infection compared to the general population. In female sex workers (FSWs), the risk of HPV infection and cervical cancer is especially high. The aim of this work is to determine the prevalence and the genotypes of Humans Papillomavirus (HPV) that circulate in female sex workers populations in Cote d’Ivoire. Methods: From December 2015 to May 2016, cervical samples from 350 female sex workers were tested for some HR-HPV. HPV DNA was amplified using PGMY09 /11 primers which generated 450 base pairs at the L1 region. The samples harboring HPV DNA were genotyped using the multiplex PCR with HPV 16, 18, 31, 33, 35, 45 and 51 primers. Results: The mean age of this population was 32.5 years. On 350 female sex workers HPV DNA was obtained in 51.5% of the population. A total of 168 (94.38%) specimens harboring HPV DNA were genotypes using multiplex PCR versus 5.61 %, which were not genotyped using HPV 16,18, 31, 33, 35, 45 and 51 by multiplex PCR. These 168 strains permit us to identify 204 strains of HPV on whom we have 88.69 % with single infection while 11.30 % with a multiple infection. Among the multiple infection 36.84 % ...

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American Journal of Cancer Research and Reviews