American Journal of Clinical Research and Reviews


A Systemic Review on the Pharmacognosy, Phytochemistry, Pharmacological and Clinical aspects of Edible stemmed vine, Cissus quadrangularis L

Review Article of American Journal of Clinical Research and Reviews A Systemic Review on the Pharmacognosy, Phytochemistry, Pharmacological and Clinical aspects of Edible stemmed vine, Cissus quadrangularis L Anoop Austin Head - Research and Development Center, Cholayil Private Limited, # 31-A/24, 4th Cross Main road, SIDCO Industrial Estate (North Phase), Aavin Dairy road, Ambattur, Chennai - 600 098, Tamilnadu, India. Cissus quadrangularis Linn. belonging to the family Vitaceae is a common perennial climber, which is distributed throughout India. This square stemmed vine is widely used in traditional systems of medicines and parts like stem, roots and shoots are the most important parts, which are used medicinally. The article reveals a wide number of phytochemical constituents that had been isolated from the plant, which plays major role including gallic acid derivatives, steroids, iridoids, flavonoids, stilbenes and triterpenes, which possesses activities like anti inflammatory, anti tumor, gastro protective, antioxidant, antimicrobial and various other important medicinal properties. Many extensive research works had been done to prove its biological activities and pharmacology of its extracts. The current review deals with the enormous amount of updated information of scientific research and reports available in different aspects of this plant involving phytochemical, pharmacology, toxicological and clinical works. This review also includes reports on pharmacognosy, variants and traditional medicinal uses of the plant. Keywords:  Cissus quadrangularis; Vitis quadrangularis; Vitaceae; Bone Fracture; Edible stemmed vine ...

Clinical and Histopathological Findings in Patients with Follicular Dermatoses: All Skin Diseases Starts in the Hair Follicles as New Hypothesis

Research Article of American Journal of Clinical Research and Reviews Clinical and Histopathological Findings in Patients with Follicular Dermatoses: All Skin Diseases Starts in the Hair Follicles as New Hypothesis *Professor Khalifa E. Sharquie MD,PhD,FRCP Edin, *Professor Adil A. Noaimi MD, DDV, FICMS, **Dr. Rusul A. Flayih MD. *Department of Dermatology, College of Medicine, University of Baghdad. Iraqi and Arab Board for Dermatology and Venereology, Baghdad Teaching Hospital, Medical City, Baghdad, Iraq. ** Center of Dermatology; Baghdad Teaching Hospital; Medical City, Baghdad, Iraq. Background: Follicular dermatoses are group of skin diseases characterised by follicular lesions during the course of the disease. Objective: To gather all skin diseases where there is follicular lesions to be evaluated in order to reach the hypothesis that hair follicles are the most principal target area in the etiopathogenesis of these skin disorders. Patients and Methods: This is a descriptive, clinical and histopathological study that was carried out at the Department of Dermatology, Baghdad Teaching Hospital, Medical City, and Baghdad, Iraq during the period from November 2018 to August 2019. Sixty patients with different follicular dermatoses were enrolled and all socio- demographic data related to the disease was obtained from each patient, in addition to physical examination was performed for each patient. Biopsies were taken from 40 patients, for histopathological evaluation. Results: Sixty patient, were included in this study, 35 patients males and 25 patients females with male to female ratio 1.4:1. Their ages ranged from 1-80(30.2 ± 16.96) years. All patients had follicular lesions. The histopathological results showed: perifollicular lymphocytes, follicular invasion and degeneration, follicular plugging, fibrous tract remnant, perifollicular melanophages and absent melanin pigment in the epidermis of patients with vitiligo. Conclusion: The result of the present study showed that all skin diseases start in the hair follicles and might spread to involve the ...

Rising Incidence of Rubella among Patients With Febrile Rash Illness in a South Western State of Nigeria: a Ten Year Review

Research Article of American Journal of Clinical Research and Reviews Rising Incidence of Rubella among Patients With Febrile Rash Illness in a South Western State of Nigeria: a Ten Year Review KOLUDE, Olufunmilola1, EMMANUEL, Eyitayo E1, AJAYI, Paul1, ILESANMI, Mary1, IBIKUNLE, Funmi2, ONWU, Victor A2, ONYIBE, Rosemary3 1World Health Organization, Ekiti State Field Office, Ado Ekiti, Nigeria; 2State Ministry of Health, Ado Ekiti, Ekiti State Nigeria; 3World Health Organization, Southwest Zone Field office, Ibadan, Oyo State. Rubella infection is a differential diagnosis of febrile rash illnesses and its becoming more prevalent in countries yet to include Rubella containing vaccines into their routine immunization. It teratogenic effect in the first trimester of pregnancy is of public Health concern, hence this study aims to investigate the trend of Rubella infection in a Southwestern State of Nigeria over a ten-year period. A community based cross sectional retrospective study was conducted in all the 16 Local Government Areas and 177 wards of Ekiti state, using available records for Measles surveillance in the state. A review of the laboratory results of blood samples collected from all cases presenting with fever and maculopapular rashes in the state between 2010 and 2019 was done. Descriptive analysis of the data collected was done using SPSS version 22 and the results were presented in tables and charts. Level of statistical significance was set at p<0.05. A total of 4,634 cases of febrile rash illnesses were investigated during the period of study, and 2.5% (115) of them tested positive to Rubella IgM, out of which 53.9% of them were females. About 56% of all the cases of febrile rash illness in the period were below the age of 10years, 50.3% were females and 12.5% were within the reproductive age group. The trend of Rubella IgM positive cases revealed that 43% ...

Effectiveness and Safety of Apatinib Mesylate Tablet in the Treatment of Advanced Solid Tumors

Research Article of American Journal of Clinical Research and Reviews Effectiveness and Safety of Apatinib Mesylate Tablet in the Treatment of Advanced Solid Tumors LIU Gang, WANG Junfeng, GUAN Yiguo, WANG Fang, XU Yuanchun Tumour Hospital of Mudanjiang Angiogenesis is the most critical step in the development and progression of malignant tumors. Anti-tumor angiogenesis has become the most promising new strategy for tumor treatment. Rapidly growing tumor cells secrete a variety of vascular growth factors under hypoxia to stimulate tumor angiogenesis. One of the important growth factors is Vascular Endothelial Growth Factor (VEGF). Some small molecule compounds that inhibit VEGFR have been used to treat Tumors. In this study, we evaluated the effectiveness and safety of Apatinib Mesylate tablet in the treatment of advanced solid tumors. We found that Apatinib Mesylate tablet can treat advanced solid tumors. Keywords: Apatinib Mesylate Tablet, Treatment, Advanced Solid Tumors ...

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American Journal of Clinical Research and Reviews

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