American Journal of Dermatological Research and Reviews


Treatment of Recurrent Aphthous Stomatitis by Crude Topical Sesame Seed Oil in Comparison with Crude Topical Pumpkin Seed Oil

Research Article of American Journal of Dermatological Research and Reviews Treatment of Recurrent Aphthous Stomatitis by Crude Topical Sesame Seed Oil in Comparison with Crude Topical Pumpkin Seed Oil 1Professor Adil A. Noaimi MD, DDV, FICMS., 2Douaa S. Ahmed MD. 1Department of Dermatology, College of Medicine, University of Baghdad. Iraqi and Arab Board for Dermatology and Venereology, Baghdad Teaching Hospital, Medical City, Baghdad, Iraq. 2Center of Dermatology; Baghdad Teaching Hospital; Medical City, Baghdad, Iraq. Background: Recurrent aphthous stomatitis (RAS) is the most common disease of the oral mucosa in the general population. Multifactorial etiopathogenesis has been suggested to explain the cause of RAS but the exact etiology and pathogenesis still unknown. Its therapy whether topical or systemic can induce clearance but the relapse rate is high. Objective: To evaluate the efficacy and prophylactic effects of topical Sesame seed oil in comparison with Pumpkin seed oil in the management of recurrent aphthous stomatitis. Patients and Methods: This is a single, blinded, clinical, therapeutic, comparative study where 35 patients with early onset RAS were examined in Center of Dermatology -Baghdad Teaching Hospital, Medical City ,Baghdad, Iraq from April 2018-October 2019. All socio-demographic data related to the disease was obtained from each patient, in addition to clinical examination was performed for each patient. Patients were divided into 2 groups: Group A (15 patients) used crude Sesame seed oil twice daily. Group B (20 patients) was instructed to use Pumpkin seed oil in a similar way to Group A. Short term assessment of each patient of  both groups was done to evaluate the therapeutic effect of drug by using oral clinical manifestation index (OCMI). A long term assessment was done for each patient to assess the prophylactic effect of drug by using OCMI before, after 1, 2 and 3 months of therapy. They were ...

Topical Therapy of Vitiligo Using Sunlight Exposure with Lactic Acid Cream (10%) Versus Methoxsalene Solution

Research Article of American Journal of Dermatological Research and Reviews Topical Therapy of Vitiligo Using Sunlight Exposure with Lactic Acid Cream (10%) Versus Methoxsalene Solution 1Khalifa E. Sharquie, 2Wesal K. Aljanabi, 3Tamara Qais Al-Mohammedi 1Professor, MD; PhD., Department of Dermatology, College of Medicine, University of Baghdad. Iraqi and Arab Board for Dermatology and Venereology, Baghdad Teaching Hospital, Medical City, Baghdad, Iraq. 2MD; FIBMS. Dermatology Center; Medical City, Baghdad, Iraq. 3MBChB, Dermatology Center; Medical City, Baghdad, Iraq. Background Vitiligo is a common autoimmune disease to which multiple therapies have been used. Lactic acid in different modes of preparation like 15% topical solution and 1% intralesional injection has been tried effectively in treatment of vitiligo. Objectives to test the efficacy of lactic acid cream10% with sunlight exposure in treatment of vitiligo, and to be compared with topical methoxsalene solution with sunlight exposure. Materials and Methods This is an interventional, therapeutic, single blinded, comparative study that was conducted in the Center of Dermatology, Medical City, Baghdad, Iraq, between April 2018 and June 2019. Patients with generalized and localized vitiligo were included. The diagnosis of vitiligo was based on clinical characteristic loss of skin pigmentation and supported by woods light examination. The demographic features were recorded. Physical examination was done to determine the site and number of patches per patient. The patients were divided into two groups: group A patients, were treated with lactic acid 10% cream followed by sunlight exposure. While in group B, the patients were treated with topical methoxsalene solution followed by sunlight exposure. All patients were assessed, and the surface area of each patch was measured before starting the treatment and every month for 3 months of treatment. The side effects were also recorded. A follow up visit after 3 months was done. A reduction rate in the surface area ...

Follicular Dermatoses in Iraqi Patients (Clinical and Histopathological Evaluation)

Research Article of American Journal of Dermatological Research and Reviews Follicular Dermatoses in Iraqi Patients (Clinical and Histopathological Evaluation) 1Professor Adil A. Noaimi MD, DDV, FICMS, 2Dr. Rusul A. Flayih MD. 1Department of Dermatology, College of Medicine, University of Baghdad. Iraqi and Arab Board for Dermatology and Venereology, Baghdad Teaching Hospital, Medical City, Baghdad, Iraq; 2Center of Dermatology; Baghdad Teaching Hospital; Medical City,Baghdad,Iraq Background: Follicular dermatoses are skin diseases that involved the hair follicle either early or during the course of the disease. Objective: To collect a number of dermatoses where there is follicular involvement, to be studied and analysed in order to reach a conclusion that hair follicles are the most important target area in the pathogenesis of these dermatoses. Patients and Methods: This is a descriptive, clinical and histopathological study that was carried out at the Centre of Dermatology and Venereology, Baghdad Teaching Hospital, Medical City, Baghdad, Iraq during the period from December 2017 to August 2019. Forty patients with follicular dermatoses were included and all socio- demographic data related to the disease was obtained from each patient, in addition to clinical examination was performed for each patient. Lesional biopsies were done for 20 patients, for histopathological examination by Haematoxylin and Eosin (H&E). Results: The mean age ± SD was 30.2±16.96 years, 25 patients were males and 15 patients were females, the clinical diagnosis of follicular diseases was established for all skin diseases included in the present work. The histopathological findings of lesional biopsies were mainly: perifollicular lymphocytes, follicular invasion and degeneration, follicular plugging, fibrous tract remnant, perifollicular melanophages and hair follicle cyst. Conclusion: The result of the present study does encourage us to suggest that almost all skin diseases included in this study start initially on the hair follicle and then spread to involve the adjacent epidermis ...

Clinical and Histopathological Evaluation of Prurigo Nodularis

Research Article of American Journal of Dermatological Research and Reviews Clinical and Histopathological Evaluation of Prurigo Nodularis 1Khalifa E. Sharquie MD, PhD, FRCP Edin, 2Safa Ibrahim MD 1Department of Dermatology, College of Medicine, University of Baghdad. Iraqi and Arab Board for Dermatology & Venereology, Baghdad Teaching Hospital, Medical City, Baghdad, Iraq. 2Center of Dermatology, Medical City Teaching Hospital. Background: Prurigo nodularis (PN) is a well-defined chronic recognized entity as a cause of severe chronic itching. However, this medical problem is not well studied and evaluated previously in Iraqi population. Objective: To do full clinical and histopatholgical evaluation of patient with PN. Patients and methods: This study is an observational cross sectional that was conducted at the Center of Dermatology, Medical City Teaching Hospital. All cases with classical PN and localized variant where collected. Full clinical evaluation was carried out. Biopsies were taken from 10 patients out of 50 with prurigo nodularis processed and stained with Hematoxylin and Eosin. Results: Fifty patients were included, there were 22 (44%) males and 28 (56%) females ,their  ages ranged  from  less than 20-60 years with mean ± SD of  age (40 ± 16) years .The common associated disease was atopic dermatitis in 36 (72%)  patients, while family history of disease was seen in 24 (48%) patients, psychological factor  was seen in 30 (60%) patients . The clinical picture was excoriated nodular lesions commonly on limbs with symmetrical fashion in 40 (80%) of cases while localized pattern was detected in 10 (20%) of patients. Histopatholgical evaluation in ten patients had shown hyperkeratosis (100%), acanthosis (60%), and pseudoepithelamatous hyperplasia (40%). Eosinophils were seen in one patient. Conclusion: This study showed classical prurigo nodularis in 80% of cases while localized in 20% of the patients. It is a disease of middle age patients, more in females than ...

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American Journal of Dermatological Research and Reviews (ISSN:2638-1893; DOI:10.28933/AJODRR) is a peer reviewed open access journal publishing research manuscripts, review articles, editorials, letters to the editor in Dermatological Research and Reviews (Indexing information).

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American Journal of Dermatological Research and Reviews

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