American Journal of Dermatological Research and Reviews


Clinical and Histopathological Evaluation of Prurigo Nodularis

Research Article of American Journal of Dermatological Research and Reviews Clinical and Histopathological Evaluation of Prurigo Nodularis 1Khalifa E. Sharquie MD, PhD, FRCP Edin, 2Safa Ibrahim MD 1Department of Dermatology, College of Medicine, University of Baghdad. Iraqi and Arab Board for Dermatology & Venereology, Baghdad Teaching Hospital, Medical City, Baghdad, Iraq. 2Center of Dermatology, Medical City Teaching Hospital. Background: Prurigo nodularis (PN) is a well-defined chronic recognized entity as a cause of severe chronic itching. However, this medical problem is not well studied and evaluated previously in Iraqi population. Objective: To do full clinical and histopatholgical evaluation of patient with PN. Patients and methods: This study is an observational cross sectional that was conducted at the Center of Dermatology, Medical City Teaching Hospital. All cases with classical PN and localized variant where collected. Full clinical evaluation was carried out. Biopsies were taken from 10 patients out of 50 with prurigo nodularis processed and stained with Hematoxylin and Eosin. Results: Fifty patients were included, there were 22 (44%) males and 28 (56%) females ,their  ages ranged  from  less than 20-60 years with mean ± SD of  age (40 ± 16) years .The common associated disease was atopic dermatitis in 36 (72%)  patients, while family history of disease was seen in 24 (48%) patients, psychological factor  was seen in 30 (60%) patients . The clinical picture was excoriated nodular lesions commonly on limbs with symmetrical fashion in 40 (80%) of cases while localized pattern was detected in 10 (20%) of patients. Histopatholgical evaluation in ten patients had shown hyperkeratosis (100%), acanthosis (60%), and pseudoepithelamatous hyperplasia (40%). Eosinophils were seen in one patient. Conclusion: This study showed classical prurigo nodularis in 80% of cases while localized in 20% of the patients. It is a disease of middle age patients, more in females than ...

Single Oral Dose of Ivermectin as a New Therapeutic Trial for Contacts of Patients with Scabies

Research Article of American Journal of Dermatological Research and Reviews Single Oral Dose of Ivermectin as a New Therapeutic Trial for Contacts of Patients with Scabies Khalifa E. Sharquie1, Adil A. Noaimi2, Riyam A. Flayyih3 1Professor, MD, PhD, FRCP Edin, Department of Dermatology, College of Medicine, University of Baghdad. Iraqi and Arab Board for Dermatology and Venereology, Baghdad Teaching Hospital, Medical City, Baghdad, Iraq. 2Professor, MD, DDV, FICMS, Department of Dermatology, College of Medicine, University of Baghdad. Iraqi and Arab Board for Dermatology and Venereology, Baghdad Teaching Hospital, Medical City, Baghdad, Iraq. 3MD, Center of Dermatology; Baghdad Teaching Hospital; Medical City, Baghdad, Iraq. Background: Scabies is one of the common epidemic and endemic diseases worldwide. Many topical therapeutic modalities for scabies are available. Topical ivermectin has been used effectively in treatment of scabies but there is no oral effective therapy that prevents contacts to get scabies. Objective: To evaluate the effectiveness of oral ivermectin in prevention of scabies contacts to get scabies. Patients and Methods: The study is a single-blinded therapeutic study that was conducted in the Center of Dermatology, Baghdad Teaching Hospital, Baghdad, Iraq during the period from April 2018 through October 2019.Two hundred sixty healthy scabies contacts were included in this study, their ages ranged from 5-60 years with a mean ± SD of 19.3± 1.9 years. All these contacts were screened for active scabies and they were all free. The contacts of scabies were treated by ivermectin tablet 200 microgram per kg as a single dose after 2 hours from dinner. They were seen regularly after 4 weeks to be re-examined and to record any scabies and drug side effects. Results: The response after four weeks of single dose therapy of healthy contacts showed that 245 (94%) from 260 were free of scabies and only 15(6%) contacts ...

Keratosis Pilaris Rubra Totalis: Clinical and Histopathological Study with New insights

Research Article of American Journal of Dermatological Research and Reviews Keratosis Pilaris Rubra Totalis: Clinical and Histopathological Study with New insights 1Professor Khalifa E. Sharquie MD; PhD; 1Professor Adil A. Noaimi MD; FICMS.; 2Dr. Raed I. Jabbar MD; CABD. 1Department of Dermatology, College of Medicine, University of Baghdad. Iraqi and Arab Board of Dermatology and Venereology, Center of Dermatology and Venereology, Medical City, Baghdad, Iraq.2Center of Dermatology and Venereology, Medical City, Baghdad, Iraq Background: Keratosis pilaris rubra (KPR) is a common but unrecognized follicular keratinizatioin. It is a common skin problem among Iraqi population and most cases were misdiagnosed as dermatitis as there are few reports in medical literature. Objective: To do full clinical and histopathological evaluation of  KPR in Iraqi population. Patients and Methods: This is case descriptive, clinico-histopathological outpatient based study. It was done in the Center of Dermatology and Venereology, Baghdad Teaching Hospital, Medical City, Iraq during the period from March 2016 to October 2017. Sixty patients were enrolled in this study. History and dermatological examination were carried out for all patients. Skin biopsy was done for 10 patients for histopathological study using Hematoxylin and Eosin stain. Results: A total of the 60 patients were diagnosed as KPR during the study period. Thirty nine (65%) males and 21 (35%) females. The age at onset of disease ranged from since birth to 8 (2.9± 2.17) years . Facial involvement included the cheeks in 60 (100%) patients. Other sites of involvement included the arms where the lateral aspects involved in 60 (100%) patients and the medial aspect 11 (18.3%), thighs including the buttocks in 51 (85%), trunk 25 (41.6%), legs 22 (36.6%) and the neck 15 (25%).The rash was erythematous all over but most obvious on the sides of face presenting as red, rough face. Histopathological evaluation showed follicular ...

Oral Ivermectin should be considered as a Magic Therapy for Scabies with 98% Cure

Research Article of American Journal of Dermatological Research and Reviews Oral Ivermectin should be considered as a Magic Therapy for Scabies with 98% Cure 1Professor Khalifa E. Sharquie MD, PhD, FRCP Edin, 2Professor Adil A. Noaimi MD, DDV, FICMS, 3Dr. Riyam A. Flayyih MD. 1Department of Dermatology, College of Medicine, University of Baghdad. Iraqi and Arab Board for Dermatology and Venereology, Baghdad Teaching Hospital, Medical City, Baghdad, Iraq. 2Department of Dermatology, College of Medicine, University of Baghdad. Iraqi and Arab Board for Dermatology and Venereology, Baghdad Teaching Hospital, Medical City, Baghdad, Iraq. 3Center of Dermatology; Baghdad Teaching Hospital; Medical City, Baghdad, Iraq. Background: Scabies is one of the commonest endemic pruritic diseases all over the worldwide. Many topical therapeutic options for scabies are available, but none of them could be accepted by many patients as all of them need covering the whole body by ointment overnight. Accordingly patients are looking for safe oral therapy like many other diseases. Objective: To assess the effectiveness of oral ivermectin in the treatment of scabies. Patients and Methods: This single, blinded, therapeutic work was conducted in the Center of Dermatology and Venereology, Baghdad Teaching Hospital, Baghdad, Iraq during the period from April 2018 through October 2019. Fifty of patients with scabies were involved in this study. All socio-demographic data that related to the disease were obtained from each patient. History and clinical examination was done for each case to establish   the diagnosis. Fifty patients treated by ivermectin tablet 200 microgram per kg as a single dose on empty stomach and repeated after one week. The patients were seen regularly every 2 weeks for 4 weeks duration after stopping therapy, to re-asses cure and to report any local or systemic side effects. Results: A total of 50 patients were included in this study, 21 (42%) ...

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American Journal of Dermatological Research and Reviews (ISSN:2638-1893; DOI:10.28933/AJODRR) is a peer reviewed open access journal publishing research manuscripts, review articles, editorials, letters to the editor in Dermatological Research and Reviews (Indexing information).

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American Journal of Dermatological Research and Reviews

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