American Journal of Histology and Cytology

Cell Death Pathways on Cancer Therapy

Review Article of American Journal of Histology and Cytology Cell Death Pathways on Cancer Therapy Neto, P. P. M 1; Silva, M. R. P 2; Soares, C. L. R 1; Lucena, C. C. O 3; Silvino, P 4; Silva, T. G 5 1Postgraduate Program of Biological Sciences, Federal University of Pernambuco - UFPE, 2Undergraduate student of Biological Sciences, Federal University of Pernambuco – UFPE; 3Postgraduate Program of Pharmaceutical Sciences, Federal University of Pernambuco - UFPE; 4 Postgraduate Program of Northeast Biotechnology Network - RENORBIO, Federal University of Pernambuco - UFPE; 5 Professor/Researcher on Department of Antibiotics, Federal University of Pernambuco - UFPE. Introduction: Cancer is a disease characterized by uncontrolled cell proliferation. The development of new drugs effective in the cancer treatment seeks the selectivity in inducing cell death. Different cell death pathways are known to date, the main ones are apoptosis, necrosis and autophagy. Objective: To describe the main cell death regulatory pathways and the possible targets of new anticancer drugs. Methodology: A bibliographic review of the scientific literature published in international journals was carried out. Results and Discussion: Apoptosis is a programmed cell death that controls the balance between death and tissue proliferation, and cancer cells are able to evade this mechanism. It can be induced by the extrinsic pathway, where receptors of the TNF- or CD95 family are activated on the cell surface, which subsequently activate cytosolic proteases, the caspases; or by the intrinsic pathway, where apoptosis is induced by the release of apoptogenic factors by mitochondria. Bcl-2 family proteins are highly involved in this pathway. Autophagy is a type of death in which the cell eliminates unhealthy cytoplasmic components by lysosomal degradation. The autophagic process is highly controlled, among others, by components of the PI3K-Akt-mTOR pathway, becoming key targets in anticancer therapy via autophagy induction. Finally, ...

Differential Diagnosis for Incisive Channel Cysts

Review Article of American Journal of Histology and Cytology Differential Diagnosis for Incisive Channel Cysts Santos, G. A. 1; Ramos, L. V. S. 2; Santana, J. F. 3; Lima, L. F. A 4; França, L. C. 5; Maia, C. S. 6 1,2,3,4,5 Student of the Dentistry Course - UFPE; 6Docente / researcher of the Department of Embryology and Histology of UFPE. Introduction: Nasopalatine duct cysts are common entities of the jaw, but may resemble clinical and radiographic findings to other cystic and solid lesions of the medial anterior maxilla. It can develop at any age, but it is more frequent between the fourth and sixth decades of life affecting men more frequently. Its etiology seems to be associated with the proliferation of epithelial remnants of the nasopalatine duct or from oronasal ducts within the incisor canal. Objective: To discuss the relevant microscopic and differential diagnosis features in clinical dental practice through recent publications. Methodology: An integrative review was performed on the MEDLINE and LILACS databases, using the descriptors: Cyst, Incisor channel, lesions. Inclusion criteria were: full-text articles available in Portuguese or English and with a temporal cut between 2013 and 2017. Results: Five articles were selected that fit the inclusion criteria. Discussion: Nasopalatine duct cyst is the most common non-odontogenic cyst of maxillary intraosseous cyst. Due to its specific anatomical location and its proximity to the upper central incisors, this lesion is often confused with periapical cysts, which leads to difficulties in establishing the best therapy by the clinician. Its radiographic appearance shows a radiolucent area, unilocular, oval or rounded, well delimited and located along the midline of the maxilla, between the apexes of the central incisors or higher on the hard palate. The main differential diagnoses usually provided include, in addition to the nasopalatine duct cyst itself, the pe- ...

Genetic Factors and Clinical Characteristics of Early Alzheimer

Review Article of American Journal of Histology and Cytology Genetic Factors and Clinical Characteristics of Early Alzheimer Soares, T. A. B ¹; Cursino, G. T ²; Donato H. M. G ³; Luis J. M. S 4; Ferreira K. M. L. M 5; Souza M. B. R 6. 1,2,3,4,5 Medical student - UNICAP; 6Professor/researcher at the Department of Biological Sciences and Health - UNICAP; Introduction: Alzheimer’s disease (AD) is an irreversible and progressive neurodegenerative disorder of insidious onset that causes loss of memory and various cognitive disorders. Early AD represents 5% of all cases of this pathology, demonstrating a family recurrence that initially presents a relative preservation of cognition. Its development is directly related to mutated genes that cause changes in the proteins encoded by them. Objectives: To describe the genetic factors and clinical characteristics of early Alzheimer’s disease. Methodology: Articles published between 2000 and 2010 were pre-selected through the PubMed and SciELO databases, using the descriptor: alzheimer. A total of 73 texts were analyzed, of which 54 were selected after the study of titles and abstracts. Considering inclusion and exclusion criteria, only 13 were included in the review because they refer to Early AD theme in the descriptors and abstracts. Results and Discussion: The genetic factor is considered crucial in the disease. The cases behave according to an autosomal dominant monogenic hereditary pattern in heterozygous individuals for the mutated gene (Aa), since the dominant gene is rare in the population. Studies suggest that the reduction in the level or activity of APP fragments plays a critical role in cognitive dysfunction, including the genes of PSEN1 and PSEN2 as well as responsible for this involvement. Early signs tend to be ignored because of their early character, presenting characteristics of behavioral changes, personality or depressive symptoms, with relative cognitive preservation. Conclusion: Early ...

The Review Process mainly includes those steps: Receive a invitation to review, Accept invitation, Review the manuscript, Submit your review. As a reviewer of eSciPub publisher, you will receive our invitation to review a manuscript by e-mail.

Please make sure that you are a expertise within the area of the manuscript and without any conflict of interest with the manuscript you will review. Please keep in mind that manuscripts emailed to reviewers are for the purpose of critical evaluation only. Reviewer must keep manuscripts and the review process confidentially. As a reviewer, he/she should review and return their comments in a timely manner. If you can not submit your comments in the agreed time, please inform us ASAP to avoid any delays.

Once finish the review process of a manuscript, you should submit your comments to eSciPub editors. The specific recommendations are as follows:

• Accept

• Minor revision

• Moderate revision

• Major revision

• Reject

Manuscript Title: The title should be a brief phrase.

Author Information: List full names and affiliation of all authors, including Emails and phone numbers of corresponding author.

Abstract: The abstract should be less than 500 words. Following abstract, a list of keywords and abbreviations should be added. The keywords should be no more than 10. Abbreviation are only used for non standard and long terms.

Introduction: The introduction should included a clear statement of current problems.

Materials and Methods: This section should be clearly described.

Results and discussion: Authors may put results and discussion into a single section or show them separately.

Acknowledgement: This section includes a brief acknowledgment of people, grant details, funds

References: References should be listed in a numbered citation order at the end of the manuscript. DOIs and links to referenced articles should be added if available. Abstracts and talks for conferences or papers not yet accepted should not be cited. Examples Published Papers: 

1.Santos, G. A.; Ramos, L. V. S.; Santana, J. F.; Lima, L. F. A; França, L. C.; Maia, C. S. Differential Diagnosis for Incisive Channel Cysts.American Journal of Histology and Cytology, 2018, 1:3. DOI: 10.28933/ajohc-2018-05-1803 
2.Soares, T. A. B; Cursino, G. T; Donato H. M. G; Luis J. M. S; Ferreira K. M. L. M; Souza M. B. R. Genetic Factors and Clinical Characteristics of Early Alzheimer. American Journal of Histology and Cytology, 2018, 1:2. DOI: 10.28933/ajohc-2018-05-1802 

Tables and figures: Tables should be used at a minimum with a short descriptive title. The preferred file formats for Figures/Graphics are GIF, TIFF, JPEG or PowerPoint.

Publication fee: The authors will be contacted about the publication fee after a manuscript have been accepted.

Proofreading and Publication: A proof will be sent to the corresponding author before publication. Authors should carefully read the proof to avoid any errors and return the proof to the editorial office. Editorial office will publish the article shortly and send a notice to authors with the links of the paper.

Open Access

American Journal of Histology and Cytology is a peer reviewed open access journal publishing research manuscripts, review articles, editorials, letters to the editor in Histology and Cytology (Indexing information).

Peer Review

To ensure the quality of the publications, all submitted manuscripts will be peer-reviewed by invited experts in the field. The decisions of editors will be made based on the comments of the reviewers.

Rapid Publication

Time to first decision: within 2 days for initial decision without review, 18 days with review; Time to publication: Accepted articles will be published online within 2 days, and final corrected versions by authors will be accessible within 5 days.  More details....

Rapid Response Team

Please feel free to contact our rapid response team if you have any questions. Our customer representative will answer your questions shortly.

American Journal of Histology and Cytology1