Most Cited

  • Dependence Structure between BRICS Countries and Developed Stock Markets: Evidence Using Wavelet and VMD Copula Approaches

    This paper investigates the comovement in stock prices between the three developed countries (the USA, UK and Japan) and BRICS countries. (Brazil, Russia, India, China and South Africa) using Wavelet Coherence and Variational Mode Decomposition(VMD) based copula approach for the period 2002-2018. We find that not all BRICS states co-move with developed countries. Brazil moves with the USA, both in long-run and short-run, while China has least interdependence with either of the developed countries, both in long-run and short-run. It is also found that Global Financial Crisis increased the interdependencies between developed and BRICS countries. The results of both the approaches validated each other. These findings are essential for investors to make the optimal portfolios or policymakers to make macroeconomic policies.

  • Airport Taxi Dispatching Based on VISSIM and Multi-objective Programming Model

    This paper solved the problem of how to manage the distribution of airport taxis and balance the revenue of long- and short-haul passenger taxis. In this research, we established a multi-objective programming model, which was solved using genetic algorithms to obtain a reasonable distribution scheme in airport with the highest riding efficiency: set up a pick-up location in the middle of the pick-up area, requiring all cars to leave uniformly when fully loaded, and release an average of 78 taxis per batch in every single boarding location. In addition, with the queuing theory we set the basic parameters of the road. Taking the income balance difference as the objective function, we used the VISSIM software to simulate the simulation. Then the short-term “priority” arrangement plan was: Calculate the ratio of the travel time of the short-distance taxi to the distance from the airport to the city center. If the ratio is less than 0.0659, the taxis that meet the conditions are allowed to be given priority after return. The results have some guidance and strong practical significance.


    This paper describes the statistical analysis of EEG signals. EEG examination is carried out and compared between controlled healthy and Mild cognitive impairment (MCI) patients which may further develop dementia or Alzheimer disease. The statistical techniques provide the comparative analysis of EEG signal. The correct evaluation of EEG provides the extraction of valuable information which is important clinically. Also, extracting significant features from EEG is an important task for classification between various patients. The analysis of EEG data provides correct frequency rhythms. The relative Power spectral density values by Auto Regressive-Burg process cleared that; associated with the control group, the relative PSD is improved in the theta rhythmic range while expressively reduced in the alpha-2 rhythmic range.

  • Kayexalate or Kalimate crystals: are they the culprits or the bystanders?

    Sodium polystyrene sulfonate (Kayexalate) or its analog calcium polystyrene sulfonate (Kalimate) has long been used to treat hyperkalemia in patients with chronic kidney disease (CKD). Although the side effect was rare, there were many case reports in the literature. Its etiology remains unclear. Lillemoe et al., on five uremic patients who developed catastrophic colonic necrosis that was temporally associated with the use of Kayexalate in sorbitol, contributed to death in four of their patients. They further provided experimental evidence implicating sorbitol as the agent responsible for colonic necrosis in a rat model. In contrast to the results of aforementioned animal study, Ayoub et al., published another experimental study in rats, they demonstrated that sodium polystyrene sulfonate (SPS), not sorbitol, was the main culprit for colonic necrosis. Recently, we encountered three patients who had hyperkalemia and were on Kalimate in water. They underwent colonic and gastric biopsy because of developing gastrointestinal symptoms. Kalimate crystals were found in all biopsy specimen, admixed with inflammatory exudate, or standing along on the mucosa surface, without provoking inflammatory reaction. We reviewed the photographs in the published case reports, they were similar to ours. Therefore, we felt that those crystals were bystanders, not the culprits. We fell that SPS ion-exchange resins, if given in water, appears to be clinically effective and reasonably safe to treat hyperkalemia in patients with CKD.

  • Gallic acid produces hepatoprotection by modulating EGFR expression and phosphorylation in induced preneoplastic liver foci in rats

    The purpose of this study was to analyze the role of gallic acid as liver protector and identify its role in the regulation of EGFR expression and phosphorylation in induced preneoplastic liver lesions in rats. Male Wistar rats were randomly divided into four groups. (1) Control; (2) animals receiving gallic acid (AG) 50 mg/kg v.o. for 8 weeks; (3) animals with preneoplasia (P) induced by a single dose of diethylnitrosamine 200 mg/kg i.p. (DEN) and two weeks after a single dose of carbon tetrachloride 2 mL/kg i.p. (CCl4); and (4) animals with preneoplasia treated with GA during 8 weeks. In order to evaluate GA hepatoprotection on preneoplastic lesions, we performed histological examination of liver tissue using H&E staining as well as an immunohistochemical analysis for PCNA. To evaluate the effect of GA on EGFR expression and phosphorylation, we performed an immunohistochemical and western blot analysis. The results indicated that GA significantly decreased EGFR expression and pY1068 EGFR phosphorylation in animals with preneoplastic lesions. GA significantly decreased PCNA expression in animals with preneoplastic lesions, suggesting it may work as an antiproliferative agent. Additionally, GA improved the architecture and organization of liver tissue and significantly decreased serum AST, ALT and FA, which are indicators of hepatocellular damage. By histopathological and immunohistochemical analysis we demonstrated an improvement in liver morphology, a reduction of preneoplastic liver foci and a reduction of cell proliferation, as well as an improvement on liver functionality. In conclusion, GA produces hepatoprotection by modulating EGFR expression and phosphorylation in preneoplastic lesions.

  • Effectiveness and safety of glecaprevir and pibrentasvir for hemodialysis patients with hepatitis C virus infection at a single center

    Background/Aims: Glecaprevir/pibrentasvir (GLE/PIB) is a pan-genotypic regimen for the treatment of hepatitis B virus (HCV) infection. GLE and PIB are direct acting antiviral (DAA) agents that can be used for patients with chronic renal failure who are on hemodialysis (HD) and those with HCV genotype 2 infections. Here, we report the usefulness and safety of GLE/PIB in 13 hemodialysis (HD) patients with HCV infection. Material and Methods: The subjects comprised patients with genotype 1 and 2 (six each) and one unknown genotype patient in whom GLE/PIB therapy was introduced by December 2018. The mean age was 69.2 (59-78) years (seven men and six women). The mean HCV RNA amount prior to treatment initiation was 4.81 (2.1-6.5). The administration periods were 8 and 12 weeks (n = 9 and 4, respectively). Results: Twelve patients received all the doses orally while an increase in total bilirubin (T-BIL) caused administration to be discontinued in one patient. HCV RNA at week 4 after treatment initiation became undetectable in 11 (91.6%) of the 12 patients. All patients achieved rapid viral response (RVR). Concerning adverse effects, although itching occurred in three (25%) patients, the symptom improved following administration of oral medication and the treatment was able to be continued. Conclusion: The results suggest that GLE/PIB can also be safely administered to HD patients. However, the usefulness and safety need to be further studied by examining more cases.


    Wounds result in functional disruption of living tissues. Herbs and their extracts have potential to regenerate damage skin. Purpose of this study was to evaluate the wound healing activity of aloe vera leaf extract in combination with curcuma longa extract. Both herbs possess anti-inflammatory and antibacterial properties. Gel-I and Gel-II were formulated using Carbopol 940, 3%w/w aloe vera leaf extract, 1 and 3%w/w curcuma longa extracts respectively and were applied on excision and incision wounds created on albino rabbits. Animals were divided into four groups having six animals, group-I was control, group-II received standard gel (Nitrofurazone), group-III received Gel-I, group-IV received Gel-II. Gels were evaluated for color, pH, clarity, viscosity, consistency, spreadability, extrudability, skin irritation test and stability studies. Gels were applied on excision wound once a day for 12 days. Wound treated with Gel-II showed better healing activity and greater percentage of wound contraction (p

  • Silent but Treacherous: A Case Report of Silent Perforated Peptic Ulcer in an Elderly Patient

    Peptic ulcer disease (PUD) is one of the most common gastroduodenal disorders. Its prevalence has been decreasing over recent years. It has multiple complications, one of which is the life-threatening perforation. The latter usually present in a dramatic clinical picture and often necessitate an emergent surgical approach. A silent gastric perforation, however, is one of the rare conditions in the clinical practice which makes the diagnosis more challenging. We describe a case of silent perforated peptic ulcer complicated with septic shock and treated by surgery. This report highlights the wide spectrum of the clinical presentations of the peptic ulcer disease.

  • Development of Emergency Archives Information Resources- Based on the Case of Sichuan Province

    Archives information resources are the first-hand data and original records for recording and responding to emergencies. They play an important role in the emergency decision-making of emergencies. Strengthening the development of emergency archives information resources is an important way to improve emergency decision-making ability. The article takes the development of archives information resources for earthquake disasters in Sichuan Province as an example, conducts research on the development of archives information resources, and conducts case analysis to point out the current problems and optimization ideas.

  • Deployment of the Telephoneaudiology in the Hospital Network of Pernambuco: Experience Report

    Objective: to report the process of implementation of educational actions in the subject of human communication health and speech therapy for professionals working in the Hospital Network of Pernambuco. Methods: This is an experience report developed after approval of the ethics committee in partnership with the State Nucleus of Telehealth of the Health Secretariat of Pernambuco. The methodological route for implantation consisted of four stages namely: 1- Technical analysis of the videoconference points 2-videoconferencing offer; 3- Evaluation of satisfaction by the target audience. Results: To date, two videoconferences have been carried out out of a total of four planned. Four State Hospital Hospitals participated in the sessions. At the events, 23 professionals participated, with an average training time of 17.86 years and who had been following up for approximately five years. The vast majority (95%) reported being satisfied with the proposal, 100% reported satisfaction with the topic addressed, with the material made available and with the technical quality and infrastructure. All said that the topics covered were important in their work process and that they would use the knowledge in their daily work. Unanimously, professionals said that the proposal should continue and that they participated in other projects in the same format. Conclusion: It is verified that the actions of permanent education mediated by information and communication technologies contribute in the professional qualification process of speech-language pathologists assisting in the clinical decision-making and in the support to integral health care of human communication.