Virological response of hepatitis Delta infection to treatment with Pegylated Interferon alpha 2a in a high prevalence country
The prevalence of Hepatitis Delta Virus (HDV) infection in Cameroon is 11.01%. Pegylated interferon alpha 2a (PEG-IFN α 2a) is the standard treatment worldwide. This study aimed to describe the virological response to this drug in cameroonians. Methods: We carried out a cross-sectional study from 1 January 2012 to 31 December 2018. It took place in eleven (11) health facilities of Yaoundé and Douala. Patients with HDV infection and treated with PEG INF α 2a for at least 48 weeks were included. The primary endpoint was Virologic Response (VR) and secondary endpoints were Rapid Virologic Response (RVR) and Late Virologic Response (LVR). Results: We included 133 patients. The mean age was 36.33 ± 10.9 years. The male sex accounted for 65.41% of cases. The VR was 67.67%. Leukopenia, fever, headache, asthenia and abdominal pain were the most common adverse events in 88.72%, 68.42%, 53.38%, 45.11% and 35.34% of cases respectively. Factors associated with VR were the presence of diabetes (aOR= 4.32; CI95% [1.22 – 15.30], p= 0.023), fever (aOR= 5.16, CI95% [1.48 – 18.04], p=0.01) and ALT levels greater than 40 IU/l (aOR= 3.69, IC95% [1.15 – 11.18], p= 0.028). Conclusion: VR is high in cameroonians. The presence of diabetes and elevated transaminases are factors associated with this virologic response. We recommend the use of interferon treatment for patients with HDV infection in Cameroon with very strict monitoring of side effects.
IMPACT OF MENTAL HEALTH AND BEHAVIORAL DISORDER DUE TO THE USE OF ALCOHOL IN THE PERNAMBUCO POPULATION: AN ANALYSIS FROM NATIONAL HEALTH INDICATORS
Introduction: Alcohol abuse does not characterize a state of character or weakness, it is a physical and psychological dependence that manipulates a dependent’s conduct and interposes between the individual, a family and other social relationships. There are 3.3 million deaths per year, due to harmful use of alcohol, and ranks as the third disease that kills the most in the world. In Brazil, it is estimated that 4.2% of the population most likely to be abused or addicted, alarming compared to the world average. Objective: To analyze the prevalence data in new cases of mental and behavioral disorders due to alcohol use, from 2014 to 2018 by sample of municipalities in the state of Pernambuco with more than 100 new cases in the period. Methodology: This is a study in secondary databases, conducted from the Brazilian Basic Data indicators, an integral tool of the health information system, using quantitative analysis of variables. Results: There was a reduction of 8% in new cases in 2018 when compared to 2014. The municipality of Vitória de Santo Antão had a greater relative reduction of new cases in the period, from 82 in 2014 to 5 new cases in 2018. Paulista presented 559 fewer new cases when comparing 2018 and 2014, this being the largest absolute reduction among the municipalities. Men were 18 times more dependent than women, and the population aged 30 to 59 years had 4.6 times more new cases than the other age groups. Discussion: It is generally observed that there were significant reductions in the number of new cases when evaluating all municipalities in Pernambuco. This may be associated with the expansion of preventive public health education policies aimed at raising awareness of the use and abuse of the population and the role of multidisciplinary teams towards the dependent patient,…
Introduction: Cannabis sativa is one of the most commonly used recreational drugs, contains over 500 different clinical compounds and over 60 known cannabinoids. Drug abuse tests are widely used as hospital screening tests for poisoning diagnoses. Objective: This study aims to understand the types of drug abuse tests used in cases of acute cannabinoid poisoning, especially in children. Methodology: This was a literature review, having as source of research the databases UpToDate, NCBI Pubmed, Online Library (SCIELO) and Toxicology Manuals. As inclusion criteria were used publications from 2000 to 2019, in Portuguese, English and Spanish, related to the keywords. Discussion: Acute cannabis poisoning is a clinical diagnosis, however, diagnosis in children may be difficult, so drug screening in the urine may be helpful to confirm the diagnosis. Conclusion: These tests are easy to perform and cheap, having good specificity through their chemical structure, directing the immunoassay to the toxic agent.
IMPACT OF MENTAL AND BEHAVIORAL DISORDERS DUE TO THE USE OF PSYCHOACTIVE SUBSTANCES IN PERNAMBUCO: AN ANALYSIS FROM NATIONAL HEALTH INDICATORS
Introduction: Psychoactive substances can cause disorders that differ from each other and varying severity and diverse symptomatology. Enabling complications in the family and social environment of the user, in addition to high rates of morbidity and mortality. Alcohol is a psychoactive substance most used by the Brazilian population, followed by caffeine, opiates, cannabinoids, cocaine and crack, with high levels of simultaneous use of two or more substances. In Brazil, it is estimated that psychoactive imports will increase, especially among young people. Objective: To analyze data from years 2014 to 2018, for example from the state of Pernambuco state with more than 100 case cases in the period. Methodology: This is a study in secondary databases, conducted from the Basic data indicator of Brazil, using the health information system, using the quantitative analysis of variables. Results: The number of new occurrences between 2014 and 2018 increased by 1.4 times. Of a total of 2971 cases, 75.3% were treated non-urgently and sometimes more often than women. The working age population (between 15 and 60 years old) presented 94.3% of new cases among those under 15 years old and over 60 years old, with the largest number of new cases in the range of 20 to 29 years old, representing 34%. Discussion: In general, there was a significant increase in the number of new cases in the population of the state of Pernambuco. Men and their age status have been progressively classified as important risk factors for mental and behavioral disorders due to psychoactive substance use. In addition, a proportion of emergency care indicates a severity of the disorder that has occurred. Conclusion: Injections in psychoactive therapies focus on health focused on psychoactive disorders, with emphasis on health promotion focused on males. The case to disregard the increasing increases of new cases over…
ASSOCIATION BETWEEN PERCEIVED STRESS AND ALCOHOL CONSUMPTION IN STUDENTS FROM IFPE – VITÓRIA’S FROM SANTO ANTÃO CAMPUS
Introduction:The term stress can be defined as a psychosocial phenomenon with biological. Alcohol has a social effect, making it more evident at school due to concern by young people.Objective:Identify the perceived stress level, the prevalence of alcohol consumption and to verify the association of the stress level with alcohol consumption among students of the Federal Institute of Education, Science and Technology of Pernambuco. Methodology: The sample consisted of 217 students, with a mean age of 15.52 (Minimum 13 and maximum 19). The most were male (52 %), semi-resident (79 %), rural (67 %). DISCUSSION: The average perceived stress was 48.22, with a minimum of 36, a maximum of 63 and a standard deviation of 5.01.About six out of ten do something to relieve stress.These data differ slightly from those found in the pilot study, where about seven out of ten students report some feeling of irritation in the past month (72.7 %), 63.6 % report that they’re feeling happy, 81.8 % of them had or are having an emotional problems that still makes them sad. Results: As mechanisms to relieve stress, eight categories were identified, most of them had used for leisure.Regarding stress, this research presents results similar to other studies involving adolescent students, however, with different assessment instruments, where the stress level ranged from 13.16 % to 73 %. Conclusion: The study points out that the stress during adolescence in the school environment is related to several factors, such as: school postage, excessive academic activities, disputes, fear of disapproval and anxiety.Regarding the consumption of alcohol, almost half already used (47 %).
Assessment of Airport Taxi Dispatching Based on Psychological Account Principle Decision Model — A Case Study of Shanghai pudong Airport
In this paper, a decision model based on psychological account principle and a queuing theory model based on (M/ M/1) system are established to solve the problem of providing more reasonable choices for airport taxi drivers. Combined with reverse test method, control variable method and other methods to analyze the problem. Taking Shanghai pudong airport as an example, the error coefficient of critical decision value is calculated to be around 0.13, and the model is reasonable. It is concluded that weather has great influence on decision making and seasonal change has little influence on decision making.
This paper studies the application of data mining in total wage distribution. The wage distribution model based on entropy method and analytic hierarchy process is established. Taking a state-owned enterprise as an example, the data was preprocessed with the linear equation fitting method. Entropy method was used to determine the weight of the influencing factors of wage distribution, and the first 8 factors were selected as the main influencing factors. The analytic hierarchy process (AHP) was used to calculate the weight of contract worker’s salary and contract employees’ salary as 0.342 and 0.658, respectively. On this basis, the total wage distribution. Compare and analyze the established distribution plan with the original distribution plan, and put forward improvement Suggestions to the original distribution plan: should increase the proportion of contract labor.
Background: Ultrathick nasal skin and nodulation is one of the most daunting challenges in cosmetic nasal surgery. Rhinoplasty is a common surgical procedure to correct mostly gross abnormal nasal anatomical variation; however, many patients have minor bizarre shape or deformities that could not be well corrected by ordinary surgical procedures. So we should find other techniques to correct these unwanted or undesired nose shape abnormalities. Objective: The purpose of this article is to perform heat dermabrasion to reduce the size of bulky nose and to create new alar groove and to remove nose nodulations, acne or traumatic scarring. Patients and methods: In this study, we collected 40 patients with bulky nose during the period from 2009 through 2019; 21 females and 19 males and their ages ranged from 20-65 years. An Informed consent was taken from each patient before starting the study, after full explanation about the procedure. All patients had bulky nose, some had nodulation of nose and acne or traumatic scarring. Only one patient had history rhinophyma of several years duration. All patients were treated with heat dermabrasion using diathermy needle after local xylocaine anesthesia and patients were received topical antiseptic and oral antibiotics to be seen after 2 weeks. Then topical corticosteroid was used to prevent post-inflammatory pigmentation. Results:A total of 40 patients diagnosed with bulky nose were enrolled in this study; 21 (52.5%) patients were females and 19 (47.5%) were males. Age of patients ranged from 20-65 years with a mean of 42.5 years. The duration of the condition ranged from few months to several years. In all patients with bulky nose were improved and alar groove were created or maximized and gave satisfactory cosmetic results using heat dermabrasion. Post-inflammatory hyperpigmentation was noticed but overtime was gone. Conclusion: heat dermabrasion using diathermy is new simple innovative…
Usefulness of Castor Oil and Elobixibat and Lactulose and Ascorbic Aid (Movicol) for Bowel Preparation for Colon Capsule Endoscopy:A Case Report
Colon capsule endoscopy was approved for reimbursement under the national health insurance system of Japan in 2014. However, the capsule excretion rate after recommended bowel preparation reportedly ranges from 70% to 90%, and administration of boosters is also necessary. The caster oil-based booster had an emission rate of 97%, but required a total water content of 3L. Some patients have been tested for the second and third time since the test was started in 2014. There is an opinion that these patients could reduce the booster more, and this time we will use the booster with mobiprep to perform the booster on the day with 350 ml.
Usefulness of Castor Oil and Elobixibat and Lactulose for Bowel Preparation for Colon Capsule Endoscopy in the patients on Dialysis -Including examination of small intestinal lesions-
Colon capsule endoscopy was approved for reimbursement under the national health insurance system of Japan in 2014. Dialysis patients are potentially susceptible to bleeding because of the fragile intestine, impaired platelet function, or oral administration of nonsteroidal antiinflammatory drugs (NSAIDs) or anticoagulants. However, the capsule excretion rate after recommended bowel preparation reportedly ranges from 70% to 90%, and administration of boosters is also necessary. For dialysis patients, liquid loading is a problem. The patient on dialysis has moisture restrictions. The caster oil-based booster had an emission rate of 97%, but required a total water content of 3L. A study was conducted on dialysis patients using a protocol in which castor oil was supplemented with Elobixibat and Lactulose to determine whether booster volume could be reduced and elimination rates improved.