Management of Oro-Cutaneous Manifestations in Behçet disease and Recurrent Oral Aphthosis, review article
Recurrent oral aphthosis is a major health problem affecting 20% of population. Its pathogenesis is not well elucidated, however, it’s considered as part of major criteria of Behçet disease. Many therapies advised to manage these ulcerations in both diseases and most of them are symptomatic, however, in the last decades; some of them have shown therapeutic as well as prophylactic roles. Herein, we review the different aspects of these therapies with emphasis on Iraqi experience.
The Effectiveness of Cream of Centella asiatica Ethanol Extract in Chitosan Nanoparticles Compared with Centella asiatica Ethanol Extract Cream, Silver Sulfadiazine Cream, and Control on Superficial Dermal Burn Healing in Rats
Introduction: Centella asiatica extract is known to promote wound healing. Nowadays nanotechnology, especially nanoparticle is used to increase the bioavailability of active ingredients into the skin, one of which is chitosan nanoparticle. However, the effectiveness of Centella asiatica ethanol extract in chitosan nanoparticle (CAEECN) towards superficial dermal burn healing is not fully understood. Aim: To determine the effectiveness of CAEECN cream compared to Centella asiatica ethanol extract (CAEE) cream, silver sulfadiazine (SSD) cream and control in superficial dermis burn healing in Sprague-Dawley rats. Materials and Methods: A total of 20 male Sprague-Dawley rats were divided into 4 groups. After anesthetizing, 4 superficial dermis burns were made on the back of each rat and was given 4 treatments (CAEECN, CAEE, SSD, and control) afterward. Each group was sacrificed separately (respectively on day 3rd, 7th, 14th, and 21st post-burn induction). Several evaluations were macroscopic (wound size), and microscopic parameters (reepithelialization ratio and distance, wound contraction index, wound size, and angiogenesis). Results: There was no significant difference in wound size between treatments on day 0, 3, 7, 14, and 21. But three active agents (CAEECN, CAEE, and SSD) treated group showed early decrease of wound size compare to control group on day-3. Microscopically, there were no significant differences in reepithelialization ratio and distance, wound contraction index, wound size, angiogenesis. Nevertheless, CAEECN treated group showed the smallest wound size on day-3 and highest angiogenesis on day 21. Conclusion: Effectiveness of CAEECN in burn wound healing in rats showed no significant difference compared to CAEE, SSD, and control. But in three active agents (CAEECN, CAEE, and SSD) treated group, showed an early decrease of wound size compared to control group on day-3. Microscopically, CAEECN treated group showed the smallest wound size on day-3 and highest angiogenesis on day 21.
EXPERIENCE REPORT: PUBLIC ATTENDANCE WITH ANAMNESIS, BIOIMPED ASSESSMENT AND BASIC SKIN CLEANING PROTOCOL SERVICES
Introduction: Concern about beauty is noticeably growing in our society. Thus, aesthetics are used to meet the search needs not only for physical well-being, but also for biopsychosocial. Skin care is essential for maintaining its vitality. Therefore, daily treatment is indispensable to establish skin balance, controlling hydration, oiliness and protection against ultraviolet rays. The importance of teaching people how to take care of their skin is essential to the quality of life, however there are still myths and conflicts to be fought about preventive care. Thereby, it helps to strengthen the construction of positive self-image, as well as collaboration to improve the quality of life, encompassing mental, physical and psychological health of the individual. Objectives: To provide participants with basic knowledge of daily facial skin care, guiding the correct order of the products to be used, prevention methods against photoaging, epidermal intoxication, oiliness and dehydration. Provide practical and explanatory demonstration on the subject, and demonstrate physiological patterns of hydration and oiliness of the patient’s skin through bioimpedance. Methodology: At first, an anamnesis form was made to evaluate the community skin routine. Factors such as age, ethnicity, history and habits were considered relevant in the condition of a skin. Then instructions were given and questions about the correct skin cleansing protocol were solved. Participants also underwent an assessment of the proportion of the amount of oil and water on their faces, made from a digital bioelectrical impedance device. Finally, the skin was cleaned following the steps of: cleaning, exfoliation, toning, moisturizing and use of sunscreen. Results: A total of 42 people were attended with the anamnesis and simple skin cleansing service, 34 female and 8 male, aged between 9 and 55 years. The data obtained with the questionnaire sheet showed that there are varied patterns of self-care regarding the skin, highlighting…
HEALTH EDUCATION ACTIVITY IN PRIMARY HEALTH CARE CENTER ON FOOD CARE IN THE EARLY YEARS OF LIFE – EXPERIENCE REPORT
Introduction: the first years of life are constituted as one of the most important phases of the human experience due to the maturation of organs, systems and vital functions. In this stage, the inappropriate nourishment with exclusive breastfeeding withdrawal and untimely introduction of solid and processed foods rich in carbohydrates and lipids through epigenetics mechanisms are related to the increased chance of developing a non-transmissible chronic disease such as obesity, being this practice discouraged and alerted by the Brazilian Society of Pediatrics. However, the lack of information and the low socioeconomic conditions lead some families to introduce these improper eating habits at this stage of life, which entails health problems according to the concepts of disease prevention and health and wellness promotion. Objective: based on that perspective, a health education action was planned and fulfilled on April 24, 2019 in the waiting room of the Primary Healthcare Center Alto dos Coqueiros, in order to take information and apply the knowledge about the cares with the early years of life closer to the present families reality. Methods: the action was structured in expositive speeches given by five medical students of the Faculdade de Ciências Médicas about caring at this stage of life, especially about nutrition. Were addressed topics like exclusive breastfeeding, introduction of solid food, allergy prevention, “first 1000 days”, however always letting the presents share experiences and make questions about the topics. Results: the activity had a significant participation of the people present, including health professionals from the unit itself, highlighting the share of experiences about financial difficulties to consume of milk formulas, misconceptions about the consume of processed food for children that soon were deconstructed and the public interest to share the knowledge acquired at that moment to their families and neighbours. Conclusion: based on the interest and interactions…
Introduction: Neural Tube Closure Defects classify the most common congenital anomalies of the central nervous system and constitute the main preventable congenital malformation through nutritional strategies. Although its mechanism of action is little known, it is known that folic acid is an important cofactor in the synthesis of amino acids and nucleic acids, therefore, the lack of this nutrient can prevent the correct cellular mitosis interfering already in the early stages of development embryonic. Objective: To evaluate the effect of dietary fortification of wheat and corn flour with folic acid on the prevalence of Neural Tube Closure Defects in Goiás. Methods: A cross-sectional study was designed to compare the prevalence of neural tube closure defects at two stages: before (2000 to 2004) and after (2005 to 2013) the introduction of mandatory supplementation of folic acid wheat and maize flour. (June 2004). Secondary data provided by the Live Birth Information System (SINASC) and Mortality Information System (SIM) for mothers living in the state of Goiás were used. Results: In the period studied (2000 to 2013), there were a total of 1,269,393 live births and 11,350 dead births, with a total of 519 cases of Neural Tube Closure Defects, resulting in a prevalence of 0.41 / 1000 births. The evaluation of the evolution of the time series of the Neural Tube Closing Defects in Goiás over the study period allows us to conclude that there was a trend of increasing prevalence in the pre-fortification period (2000 to 2004), followed by a downward trend in the period post-fortification period (2005-2013) for live births, stillbirths and all births. From 2000 to 2004, the period prior to folic acid food fortification, the total prevalence of Neural Tube Closing Defects (considering all births) was 0.42 / 1000 births, while in the period after food fortification, 2005…
Introduction: Acute pesticide poisoning is a worldwide public health problem and it is estimated that around 300,000 deaths occur each year. Epidemiological surveys of human populations exposed to chemicals are of great importance in identifying the magnitude of health damage. Objective: The general objetive of the study was to describe the epidemiological profile of acute pesticide poisoning reported by the Pernambuco Toxicological Assistance Center (CEATOX) from 2016 to 2018. Methodology: Retrospective and exploratory research with quantitative approach; from secondary data from the Brazilian Data Poisoning System (DATATOX). Results: From 2016 to 2018, 1,062 cases of acute pesticide poisoning were reported, corresponding to 8% of general poisonings. There was a predominance of the class of clandestine raticides (48%) represented by the “chumbinho”. Insecticides accounted for 43% of the cases, 8% herbicides, fungicides and growth regulators approximately 1% each. There was a predominance of poisoning in males (53%) over females (47%). The prevalent age range was 20 to 29 years (27%), followed by 30 to 39 years (24%) and subsequently 40 to 49 years (18%). A significant percentage of suicide attempts were found, representing 73% of cases. The predominant area of occurrence was urban (79%), while 21% came from the rural area. The Metropolitan Region accounted for 59% of notifications, followed by Zona da Mata (15%), Agreste (13%), Sertão (8%) and Mesorregião do São Francisco (5%). Oral exposure was prevalent, corresponding to 91%, followed by respiratory (4.2%) and dermal (3.7%). Regarding the severity of the cases, 78% had mild manifestations, evolving to cure without sequelae, 3.7% had severe manifestations and 1% evolved with sequelae. There were 113 deaths that corresponded to 10.6% of notifications. The highest lethality was observed in Clandestine Raticides (56.6%), followed by insecticides (32%), while Herbicides represented 11.5% of deaths. Conclusions: The identified profile was of oral self-poisoning by…
INTRODUCTION: Diabetes Mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion and/or action. Studies indicate that type 2 Diabetes Mellitus is related to the increased prevalence of mental health problems, especially depression and anxiety. Diagnosis is associated with an approximately 27% increase on the risk of developing depression, when compared with undiagnosed cases. OBJECTIVES: The objective of this study was to evaluate the prevalence of anxiety and depression in diabetics patients, to compare and correlate these aspects between men and women. METHODOLOGY: Participants were recruited at the Mutirão Diabetes, na event promoted in 2018 by the Municipal Health Secretariat of Goiânia/GO. After this first contact, volunteers were invited through phone calls for a blood exams and interviews. Patients with age between 40 and 60 years of both sexes were selected for the study. Symptoms related to depression were assessed by the Beck Depression Inventory (BDI), which discriminates the presence or absence of depressive behaviour. Anxiety was assessed by the State-Trait Anxiety Inventory (IDATE), which assesses symptoms related to anxiety. Blood glucose was measured and the adopted reference value was ≤99 mg/dL. Mean tests, standard deviation, Student’s t-test and Mann-Whitney tests were performed to compare means between groups and Pearson and Spearman bivariate correlation. RESULTS: The sample consisted of 96 individuals, with a mean age of 56.2 ± 9.6 years, 55.3% female and 42.7% male, and with a mean time of disease (diabetes) of 10.0 ± 7.6 years. The results showed that most of the subjects (66.7%) had their blood glucose above normal values (151.4 ± 76.6), and higher levels of trait anxiety than the reference values (43, 4 ± 6.9). When compared by gender, women had higher depression scores than men (10.4 ± 7.0; 7.8 ± 4.8; p
Introduction The project of valorization of the workers of the Municipal Health Secretariat of the city of Messias brings as priority the worker health of the community health agent and of endemics. The project was created according to the reports of the professional daily target audience during conversation rounds, which shared the need for a broader attention to the working and health conditions of the category. Thus, strategies were created aiming at actions involving the continuous care line, including health education, promotion and prevention. The actions are carried out with a multiprofessional Primary Care team, Family Health Support Center and specialized service actions involving integral, individual and collective care. Objectives To promote and prevent health education, seeking to improve physical, psychological and social aspects and strengthen the professional bond. Methodology The project is a descriptive study with a cross-sectional quali-quantitative approach. An individual assessment was performed based on the WHOQOL-bref questionnaire with some adaptations by the Family Health Support Center team. This questionnaire will be reapplied and analyzed every four months for reevaluation with the multiprofessional team to continue the care of each member of the group. The meetings are held monthly and according to the need of the community. Results Improve interaction, cooperation, rapprochement and flexibility in the category of Community Health and Endemic Agents and with other professionals, thus awakening to health care. Conclusion As a permanent project, continuous and having started this year, it has been possible to observe several reports and shared evaluations since the last monthly meeting where there was an improvement in the team relationship and acceptance of self-care. In contact with other professional categories of primary care, it can be seen in daily living, the enthusiasm of community health agents to participate in the project.
Discussion on the relationship between construction safety accident and time based on the correspondence analysis model
Based on the correspondence analysis model and the method of mining the cause and time of construction accidents. Using Python crawler technology to crawl 3896 data of the causes of construction safety accidents in China Construction Safety Supervision Information System from 2012 to 2018, a contingency table of various types and times of accidents in construction safety accidents was established. By using factor analysis, the relationship between Q-factor analysis and R-factor analysis in the corresponding factor analysis model was established. The model was analyzed and optimized by a special point removal method, and the convergence of the model was strengthened. Finally, the causes of construction safety accidents in the model and the time of one day and one year were calculated and drawn in the corresponding analysis chart of the two-dimensional model. Mining the relationship between them according to their relationship in the graph based on the data collection of 3896 building safety line accidents, this paper put forward the method of mining the main causes of accidents, and used SPSS platform technology to mine the accident data. The results showed that the occurrence of electric shock and drowning was closely related to August, fire and explosion were closely related to February, and poisoning and asphyxiation were closely related to January. 5-6 a.m. was closely related to fire and explosion, and vehicle injury was closely related to 8-9 p.m. To put forward prevention suggestions for construction accident prevention.
Virological response of hepatitis Delta infection to treatment with Pegylated Interferon alpha 2a in a high prevalence country
The prevalence of Hepatitis Delta Virus (HDV) infection in Cameroon is 11.01%. Pegylated interferon alpha 2a (PEG-IFN α 2a) is the standard treatment worldwide. This study aimed to describe the virological response to this drug in cameroonians. Methods: We carried out a cross-sectional study from 1 January 2012 to 31 December 2018. It took place in eleven (11) health facilities of Yaoundé and Douala. Patients with HDV infection and treated with PEG INF α 2a for at least 48 weeks were included. The primary endpoint was Virologic Response (VR) and secondary endpoints were Rapid Virologic Response (RVR) and Late Virologic Response (LVR). Results: We included 133 patients. The mean age was 36.33 ± 10.9 years. The male sex accounted for 65.41% of cases. The VR was 67.67%. Leukopenia, fever, headache, asthenia and abdominal pain were the most common adverse events in 88.72%, 68.42%, 53.38%, 45.11% and 35.34% of cases respectively. Factors associated with VR were the presence of diabetes (aOR= 4.32; CI95% [1.22 – 15.30], p= 0.023), fever (aOR= 5.16, CI95% [1.48 – 18.04], p=0.01) and ALT levels greater than 40 IU/l (aOR= 3.69, IC95% [1.15 – 11.18], p= 0.028). Conclusion: VR is high in cameroonians. The presence of diabetes and elevated transaminases are factors associated with this virologic response. We recommend the use of interferon treatment for patients with HDV infection in Cameroon with very strict monitoring of side effects.