Kyrle’s disease (KD) is a Chronic skin condition first described by Austrian pathologist Josef Kyrle in 1916. Kyrle referred to this condition as hyperkeratosis follicularis & parafollicularis in cutem penetrans. These diseases are characterized by the phenomenon of transepidermal elimination of denatured dermis an acquired form of perforating dermatosis . It is characterized by keratotic crater plugs that develop in hair follicles penetrating the epidermis and extending into the dermis . This trans epithelial migration and elimination of proteinaceous components is associated with systemic disorders like renal, liver diseases, chronic heart failure and diabetes mellitus. We present two case scenarios of a young Males with multiple chronic papular eruptions along with a review of literature for Kyrle’s disease (KD).
Instruments for identifying risk of terrorist offenders could help counterterrorism practitioners define parameters of effective rehabilitation and detect a change in risk level of offenders before and after treatment. This study aims to develop Motivation-Ideology-Capability Risk Assessment, known as MIKRA, to examine the level of risk of terrorist offenders. The study involved Indonesian counterter-rorism experts and practitioners for examining the construct validity of MIKRA and terrorist offenders at a maximum-security prison for analysing the external and criterion-related validity. External validity was implemented by comparing offenders’ MIKRA scores with their risk categories reported by Counterterror-rism Special Task Force. Internal consistency reliability (Cronbach’s Alpha) was also applied to examine MIKRA’s psychometric properties. The results indicate alpha reliability α= 0.933. Furthermore, offenders’ MIKRA scores are correlated significantly with categories of risk released by the official, but not correlated with the non-offenders’ scores. This means MIKRA is valid to investigate risks of terrorist offenders.
The global epidemiological trends led to the declaration of coronavirus (COVID-19) as a pandemic by the World Health Organization (WHO) on March 11, 2020. This necessitated the closure of schools, parks, and recreation and community facilities in most parts of the globe. As a result, there was a rapid shift to online education delivery, and even virtual school graduation ceremonies. Thus, children became part of the sudden behavioural changes needed to mitigate the spread of COVID-19. These changes include social distancing, frequent handwashing and stay-at-home restrictions. Some families had to cancel planned vacations, and others were forced to go into isolation or quarantine as recommended by the public health policies and guidelines. This paper reviews the psychological and behavioural impacts of the COVID-19 pandemic on school-age children.
Epithelial tissue response to pathological effects in various age groups. Participation of morphofunctional zones and Src-kinase in this process
The response of human organism tissues to various pathological effects depends to a large extent on the presence of the total amount of key protein in the organism – Src-kinase and the ratio of its active part to inactive. With a sharp preponderance of an inactive portion of this protein over the active, the proliferative activity of cells is suppressed, and with a significant preponderance of the active part, proliferation is inadequately increased. The amount of this protein is embedded in embryogenesis and individually in each person. In the age aspect, a decrease in the Src-kinase content in the human organism is observed. The epithelial tissue of two age groups: 20-40 and 75 years and older responds most acutely to pathological effects, including the entering of viruses, since in 20-40 years the number of Src-kinase is the greatest in relation to other age groups, and in 75 years and older – the least, which causes a decrease in the reactivity of organism tissues or, conversely, hyperactivity.
There is substantial evidence to suggest that mindfulness practices positively affect older adults’ physical, emotional, and cognitive wellbeing. However, there is still little information available about the interest and inclination among older adults for performing mindfulness-related exercises. We conducted a survey study aimed at exploring the prevalence of older adults engaged in such activities. Data were collected from 174 older adults (Males: 48; Females:126) who responded using a self-constructed survey, and analyzed using SPSS. Results indicate that almost two-thirds of older adult respondents engage in at least one mindfulness practice and almost a third engage in more than one, with meditation, deep breathing, and yoga being the most prevalent.
Are pediatric patients with epilepsy at higher risk for COVID-19 Retrospective analysis from Sidra Medicine, Doha-Qatar
The COVID-19 pandemic, caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), spread in few months from a small focus in Wuhan (Hubei province, China) to over 28 million people worldwide , COVID-19 is often more severe in people 60+yrs or with health conditions like lung ,heart disease, diabetes or conditions that affect their immune system (1). Several countries independently adopted strict containment measures to slow the local spread of SARS-CoV-2. As other countries, widespread lockdown measures were applied in Doha –Qatar from March 17 to June 1st 2020 that restricted physical contacts, individual movements including school attendance. This reflected during the beginning of the academic year 2020-2021 by parental fear to send their children with epilepsy back to their school considering that epilepsy could be a risk factor for covid19 infection. The prevalence of epilepsy in children ranges from 3.2 to 5.5 per 1000, being highest in the first year of life, but matching adult rates by the end of the first decade (2). Epilepsy in children is the second greatest neurological disorder burden worldwide (3), often associated with cognitive and psychiatric comorbidities (4). These patients were not highly susceptible to COVID-19 during the pandemic, the estimate rate of infection among pediatric patient with epilepsy was around (0.4%) for those who became sick. Meanwhile Viral infection is a risk factor for seizures in children with certain developmental and epileptic encephalopathies (DEE) with fever sensitivity, such as Dravet Syndrome and SCN1A-related phenotypes. We aimed to assess if the COVID-19 infection affected children with epilepsy in a higher rate than other children.
Aim and objective: The aim of this study was to investigate a relationship between the different types of electrosurgical energy (monopolar, bipolar, and ultrasonic-harmonic scalpel) and postoperative hypocalcaemia after total thyroidectomy. Additionally, to analyze the frequency of postoperative hypocalcaemia, according to age group, gender, and pathological diagnosis. Materials and Methods: An observational, retrospective and correlational study was carried out in a series of patients who underwent total thyroidectomy in a public and a private hospital in Quito, Ecuador, South America, from January 2016 to July 2019. Results: Among 665 patients, post-thyroidectomy hypocalcaemia was observed in 127 (18.8%) patients. There was no significant difference between males and females. Hypocalcaemia was significantly higher in patients aged between 26 and 35 years, patients operated for malignant tumors and in patients in whom at least one parathyroid gland was removed. Postoperative hypocalcaemia occurred in 52.2% of patients (n = 24) [RR: 3.14; 95% CI: 2.26-4.36; p: 0.001] in the bipolar group, 29.2% (n = 7) [RR: 1.56; 95% CI: 0.82-2.97; p: 0.087] in the harmonic group, 17.3% (n = 34) [RR: 0.87; 95% CI: 0.61-1.24; p: 0.219] in the monopolar group, and 15.2% (n= 60) [RR: 0.61; 95% CI 0.45-0.84; p: 0.001] in the monopolar + harmonic group. Conclusions and clinical significance: The use of a bipolar device appears to be a risk factor for hypocalcaemia, while the use of monopolar + harmonic seems to be a protective factor. Although, when analyzing monopolar + harmonic vs monopolar alone, the addition of the harmonic scalpel didn’t provide statistically significant additional protection against hypocalcaemia.
A COMPARATIVE STUDY BETWEEN LAPAROSCOPIC HERNIA REPAIR AND OPEN HERNIOTOMY OF INGUINAL HERNIA IN PAEDIATRIC AGE GROUP: A PROSPECTIVE RANDOMIZED CONTROLLED STUDY
Background: Inguinal hernia in children remains one of the most common congenital anomaly observed by surgeons. Prompt diagnosis and early treatment of the inguinal hernia continues to be the mainstay to avoid the complications. The present study was undertaken to compare the effectiveness of laparoscopic hernia repair and open herniotomy of inguinal hernia in paediatric age group. Method: A total 104 healthy children of age
Alpha-emitting nanoparticles and the Warburg Effect, skin diseases, eating disorders, musculoskeletal disorders, alcoholism, cigarette, hypersexuality and neurofibromatosis type 1
Alpha emitting nanoparticulates in internal contamination, an IARC Class 1 carcinogen, have an extremely wide list of effects. New effects are here demonstrated based on a wide epidemiological survey. WHO data in particular is used together with other large sets and juxtaposed to known sources of variations of radioactivity contamination in the environment to demonstrate the link which is always explained by the strong decay energy and its impact on the organism. Some behaviours are shown to be strategies of pain reduction, others of decontamination. This article confirms the simple logic of biophysics (the linear-no-threshold model) outlined by the author in previous publications.
This short note is of interest for depleted uranium cleaning and supraconductivity studies. It presents ways to cleanse depleted uranium efficiently.