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  • MOEBIUS SYNDROME AND ITS IMPLICATIONS FOR DENTAL TREATMENT

    Introduction: Moebius syndrome is a rare congenital neurological disease of unknown etiology, that involves several cranial nerves. The main clinical characteristic of this syndrome is the “mask-like face”, that is, the absence of facial expression in situations of sorrow or joy. Objective: This study aims to describe the characteristics of Moebius syndrome and its main implications for dentistry. Methodology: In this study, a literature review was carried out, with searches in the following databases: scholar.google.com, pubmed and medline. Furthermore, eight articles were selected, among which three were literature reviews and five were reports of clinical cases. Results: In addition to the genetic relation of the syndrome, there are factors that lead to this disorder, such as the use of misoprostol during pregnancy, for example. Conclusion: Early care for patients with Moebius syndrome by a multidisciplinary team is extremely important, since it will attenuate the effects of this pathology.

  • HUTCHINSON-GILFORD SYNDROME: A LITERATURE REVIEW

    Introduction: To review several studies and reports regarding the causes, diagnoses and characteristics of the study and development of Hutchinson-Gilford Syndrome (HGPS) or progéria. Methodology: Through articles found in the following databases: PubMed Central, Scielo, BVS, Bireme, Scientific Electronic Library Online. Discussion: The approach follows from its genetic origin to its progressive stage of incurable aging along with Therapeutic Strategies for greater well-being and longevity for the patient, in the search to minimize the various pathologies that are submitted throughout their life, trying to increase their expectation average of 13.6 years. Conclusion: Because it is a rare and incurable disease, only palliative treatments for this syndrome are found.

  • Positive Effect of Injectable Platelet Rich Fibrin (i-PRF) on Vital Bone Formation in Graft Reconstruction of the Mandible: A Histologic and Histomorphometric Study

    In this clinical case series, relative centrifugation force (RCF) and centrifugation time (CT) were reduced to produce the liquid form of platelet rich fibrin (i-PRF). The goal of this study is to histologically evaluate if the liquid form of PRF has a positive effect on vital bone formation in the grafted mandible using mineralized freeze-dried allogeneic bone. Materials and Methods: Forty-two patients completed immediate bone grafting after a non-restorable endodontically treated molar tooth was extracted in preparation for future implant surgery. Each bone graft was augmented with i-PRF. To process i-PRF, relative centrifugation force (RCF) was reduced from 2,700 RPM to 700 RPM (60g). Centrifugation time was reduced from 12 minutes to 3 minutes. After an average bone graft healing time of 8 to 12 weeks, bone core samples were obtained at the time of implant surgery for histological and histomorphometric analysis. Results: Forty-two bone cores were harvested at the time of implant surgery for histological and histomorphometric analysis. The liquid form of PRF resulted in greater percentages of vital bone formation (average 87.4 %) compared to the existing published literature. Conclusion: i-PRF resulted in greater percentages of new vital bone formation compared to the published literature. This could be due to the continuous slow release and delivery of growth factors in i-PRF. Further clinical use of iPRF is needed to evaluate the full potential of bone regeneration.

  • In-Vitro Starch Hydrolysis and Prediction of Glycaemic Indices of Biscuits Produced from Wheat, African Walnut and Moringa Seed Flour Blends

    African walnut and moringa seed were procured and processed into flours. Biscuits were thus produced from different blends of wheat flour (WHF), African walnut flour (AWF) and moringa seed flour (MSF) in the ratios of (WHT:AWF:MSF) 100:0:0, 77.5:20:2.5, 75:20:5, 72.5:20:7.5, 70:20:10, 90:0:10, 80:20:0 and labelled from A to G, respectively. The produced biscuits were evaluated for dietary fibre content, in-vitro starch hydrolysis and predicted glycaemic indices. The results of dietary fibre content of the biscuits revealed that sample E was significantly higher with a value of 0.72g compare to other samples. Dietary fibre content of the biscuits increased as the level of substitution with moringa seed flour increased. Results of the in-vitro starch hydrolysis of the biscuits showed that the percentage starch hydrolysed reached its peak at 120 min of digestion and after which, a reduction steps in as digestion time increases. Equilibrium concentration, hydrolysis index and predicted glycaemic indices of the biscuits reduced as the level of substitution of moringa seed flour increased. It revealed sample E with Equilibrium concentration value of 48.06, hydrolysis index of 51.66% and predicted glycaemic index of 68.07. Thus, the blends of 70:20:10 (WHT:AWF:MSF) which represented sample E could be used as medium glycaemic index food.

  • Effect of Aerobic Exercise Training Programme on Blood Cholesterol Profile in Prevention of Cardiovascular Diseases among Young Adults

    This study investigated the effects of aerobic exercise training programme on blood cholesterol profile as cardiovascular disease risk factor among adolescents. The study employed the true experimental of pretest post test design with one experimental and control group. The population consisted of 745 students of Ekiti State University, Ado-Ekiti. The participants for the study were 32 students comprising 22 participants for the experimental and 10 for the control groups with equal number of male and female in each case. The instruments used for sample and data collection for the study were; stadiometer, vacutainer needles, plastic vacuum tubes, vacutainer holder, tourniquet, disinfection swabs, microspore tape, adhesive dressing, rubber gloves, lithium heparin bottles and spectrophotometer. The training programme consisted of graded activities lasting for 25-40 minutes, administered three times a week for 12 weeks. The blood samples collected were subjected to chemical analysis generated for the study. The data were subjected to descriptive statistics of mean, standard deviation and range and inferential statistics of Analysis of Covariance (ANCOVA). Multiple Classification Analysis (MCA) was employed to determine how much effect the treatment had on the cholesterol profile of the students. Statistical analysis showed significant reduction of total cholesterol, low density lipoproteincholesterol, and increase high density lipoprotein cholesterol. Aerobic exercise training programme had positive effects on total cholesterol, low density lipoprotein cholesterol, and high density lipoprotein cholesterol levels of the adolescents. It is therefore recommended that behavioural counseling will goal on way re-orientating the adolescents towards aerobic exercise training programme which will help in preventing cardio vascular diseases in adult population.

  • Alzheimer’s Disease & Dementia-From Pathophysiology To Clinic

    Dementia is a syndrome that occurs due to the difficulty of a patient in doing his cognitive and instrumental activities of daily life with the same performance as before, bringing him losses. This syndrome is caused by numerous primary and secondary etiologies. The most common primary cause of dementia is Alzheimer’s disease (AD), which reaches almost 50% of dementia cases. The DA it consists of biological fragments of the amyloid precursor protein that are deposited in the brain 10 years or more, before the first symptoms appear. The period before the onset of symptoms is called the preclinical stage. The transition between the silence of symptoms and their appearance, usually due to memory loss for recent events, is known as the prodromal phase. Continuing the pathophysiological process, the stage of mild dementia takes place, when the patient has one more cognitive component associated with memory loss; follows the moderate, severe, profound and terminal phase of dementia.

  • A Patient with ACHOO – The Autosomal Dominant Compelling Helio-Ophthalmic Outburst syndrome

    Case report: The patient is a 36-year-old woman who was referred to our allergy-immunology clinic by her primary care physician to be assessed for a possible allergic disorder. The patient states that since early teenage she has had frequent bouts of sneezing generally preceded by nasal itching and often occurring when she first goes outdoors. She denies having a chronic cough or wheezing and has no symptoms suggestive of allergic conjunctivitis or sinusitis. She has not had urticaria or anaphylactoid reactions. Her mother and 29-year-old sister have similar complaints but have never been assessed for possible allergies. The patient’s medical history is otherwise unremarkable. On physical examination her vital signs were within normal limits. Her conjunctivae were not inflamed or edematous and she had no edema or pallor of her nasal mucosa and no tenderness of her paranasal sinuses. Her lungs were clear to auscultation and free of wheezes on deep breathing. The remainder of her exam was unremarkable. Laboratory assessment revealed a normal complete blood count and metabolic panel. Skin testing to 66 regional allergens was negative, and her serum IgG, IgA, IgM, IgD, and IgE levels were within normal limits. Because she was suspected as having ACHOO, she was dark adapted and then exposed to a bright light which instantaneously precipitated her nasal itching and sneezing, confirming the diagnosis.

  • Advancing Financial Inclusion and Inclusive Growth in India: An impact assessment of Policy Measures

    Financial Inclusion and Inclusive Growth are indispensable for the economic growth of a nation. Financial resources need to be distributed equitably to the unreached and poor sections of the society who have limited access to banking facilities. Pradhan Mantri Jan Dhan Yojana (PMJDY) is a policy initiative of the Government of India in this direction. In this study an attempt is made to understand the extent of financial inclusion through banking activities in India post implementation of PMJDY considering banking growth and resultant financial inclusion by means of major banking variables such as Deposits and Credits of banks in India before 2014 and after 2014 (the year of implementation of PMJDY)

  • Seeing is Believing: The Effects of Word of Mouth on Homestay Tourists’ Behaviour Intention

    This study employs structural equation model that establishes the effect of face-to-face word of mouth and electronic word of mouth directly on homestay tourists’ behaviour intention or through homestay image and attitude. Total 521 valid questionnaires are collected both online and offline. Analysis was performed using SPSS and Mplus7.0. The results illustrate that face-to-face word of mouth has no significant influence on homestay image, attitude and tourists’ behaviour intention while electronic word of mouth has a great effect on them. The homestay image and attitude which play mediating roles in the model also have significant impact on behaviour intention. Further practical implications of the study are discussed along with recommendations for future development of the homestay word of mouth management and marketing.

  • ESTIMATION OF THE SACRIFICE RATIO BETWEEN INFLATION AND GROWTH IN NIGERIA

    Relying on the adaptive expectations Augmented Phillips Curve approach, the study estimated the sacrifice ratio for inflation that is conducive for growth in Nigeria and found the ratios for the constructed models I and II to be positive. The sacrifice ratio measures how much output is lost in the country when inflation is reduced by 1 percentage point through monetary policy action. The outcome of our study suggests that a 1 percent disinflation accomplishment leads to an output loss of 0.07%. Also, for a given period, power of persistence effect coefficient is 0.71 on the average, suggesting that, disinflation policy has a more robust and long-lasting impact on the country’s real GDP.