Oral Lesion like Mucous Membrane Pemphigoid under Carboplatin-induced Hemolytic Anemia and Pancytopenia as Hypersensitive Reactions in a case with Maxillary Sinus Cancer: A Case Report
Here we report the first case of fatal carboplatin induced immune hemolytic anemia in a patient with head and neck malignant neoplasms followed by onset of multi-organ failure. While carboplatin is an effective agent used to treat many kinds of malignant tumorigenic lesion, a number of reports about allergic side effects are present. A 64-year-old male patient diagnosed as maxillary sinus cancer was treated by radiation therapy associated with weekly intravenous infusions of carboplatin. After five times of carboplatin infusion, white blood cell and platelet counts and hemoglobin value gradually decreased, and reached to almost bottom level. Both direct and indirect coombs tests were negative. Reticulocyte count and the value of platelet-associated IgG were high level, and oral lesion-like mucous membrane pemphigoid appeared on tongue and hard plate. Recognition of the particular oral abnormality in the early stage could allow for correct diagnosis and a potentially effective therapy. Funding: This study was supported in part by JSPS KAKENHI Grant Number 18K09885.
Aiming at the problems of rice seedling raising, transplanting and so on, low production efficiency and low mechanization efficiency, we popularize the rice direct seeding technology, through investigating and studying the development status of representative rice direct seeding machine in China, analyze its basic structure and working principle, and put forward the existing problems and development suggestions of rice direct seeding machine. Research shows that rice direct seeding technology has a broad development space in China. It is necessary to further optimize the design of key components such as seed metering devices and improve independent research and development capabilities to improve the versatility and efficiency of the rice direct seeding machine, so that China’s rice direct seeding technology can Rapid development.
Invasive Haemophilus influenzae disease in Northwestern Ontario First Nations communities: Case Series
We present clinical and microbiological data of 5 pediatric cases of invasive Haemophilus influenzae disease, which occurred over a period of 10 months in the service area of a regional hospital of Northwestern Ontario. Four cases of invasive H. influenzae type a (Hia) disease presented either as meningitis, non-complicated and complicated pneumonia, or soft tissue infection in children between 7 months and 6 years of age. Although the cases were from different communities with no known common exposure, the Hia isolates demonstrated similar phenotypic and genotypic characteristics. One case of invasive disease due to nontypeable H. influenzae (NTHi) presented as chorioamnionitis in an adolescent. The data emphasize the significance of Hia and NTHi as a cause of serious disease in Indigenous communities.
Clinical governance is a comprehensive approach that is not given its weight as a subject at the undergraduate level because either the syllabus is full or there is not enough time. This article aims to facilitate the understanding of clinical governance in the dental office by drawing modules. These color modules and the ease of structure will tempt the eyes of undergraduate dental students. The benefit is also extended to include the general population to inform them about the importance of dental hospitals to practice a high level of clinical care, thus increasing awareness. Improving the quality of life depends on policies and procedures built on the contemporaneous reliable, evidence-based information. The teaching of clinical governance and legislation and ethics at the undergraduate level should be included in the dental syllabus. This article will cast a glance at the future of professionalism against the background of increasing expectations from patients.
Vascular neoplasms are the most common primary nonhematopoietic tumors of the spleen. They include hemangiomas, littoral cell angiomas, splenic hamartomas, lymphangiomas, hemangioendotheliomas, angiosarcomas, and Sclerosing Angiomatoid Nodular Transformation (SANT)1. SANT is a rare and benign lesion arising from the red pulp of the spleen 2.Martel et al first described the disease entity in 2004 in middle aged- adults with slight female preponderance , the etiology and pathogenesis are still not clear3, SANT poses diagnostic clinical and radiological challenges4, we present this case report with review of the literature.
Curriculum Content, Ownership Of Universities, Work Experience And Acquisition Of Employability Skills Among Business Education Graduates Of Universities In Cross River State, Nigeria
This paper x-rayed curriculum content, ownership of universities, work experience and acquisition of employability skills among business education graduates of universities in Cross River State, Nigeria. Two formulated research hypotheses guided this study. Literature was reviewed in line with the variables under study. The research design adopted was survey. The population for the study was 987 business education graduates between 2007/2008 and 2014/2015 academic sessions from the University of Calabar (UNICAL) and Cross River University of Technology (CRUTECH). The sample of the study was 200 business education graduates drawn purposively using accidental and snowballing sampling techniques. A validated researcher- made four point scale questionnaire titled ‘Curriculum Content, ownership of universities, work experience and Acquisition of Employability Skills Questionnaire (CCOUWEESQ) was used for data collection. The instrument was validated by four research experts. A reliability estimate of .70 to .82 was achieved for the instrument using Cronbach Alpha reliability coefficient after a pilot test. The data obtained from the field was converted into values and analyzed using independent t-test statistical technique. All hypotheses were tested at .05 level of significance. Findings revealed among others that graduates of federal university exposed to business education curriculum content are significantly different from their state university counterparts in their acquisition of employability skills. Based on this, it was recommended that government should accord equal recognition, support and provision (in terms of funding, capacity building and infrastructural spread) to both federal and state universities in a way that obvious preference for one category over the other is not perceived. Doing so may erode the dichotomized feelings of being either in a federal or state university from the minds of the students, and rather fix their focus on quality learning that results in the acquisition of employability skills.
Colo-renal fistula following percutaneous radiofrequency ablation of a renal tumor. A case report and review of treatment options
Background: Colo-renal fistula formation is a very rare complication following percutaneous radiofrequency ablation (RFA) in the management of renal cell carcinoma. In this paper we describe the management of a patient with a left colo-renal fistula occurring after renal tumor RFA. Additionally, we present a thorough literature review of reported cases of colo-renal fistulae after percutaneous RFA to further highlight their treatment challenges. Summary: Two weeks after undergoing percutaneous RFA of an incidental 3cm left renal mass, a 67-year-old male was re-admitted to the hospital with a symptomatic colo-renal fistula. Patient ultimately failed conservative management with broad spectrum antibiotics and ureteral stent placements, and subsequently underwent segmental colonic resection and renorrhaphy, with complete renal preservation. Conclusion: Although complications after RFA of renal tumors are rare, iatrogenic colo-renal fistula formation is a significant complication requiring a multi-disciplinary approach with a trial of non-operative management prior to surgical intervention.
A feature of the modern society is the city which tries to express itself by means of social and physical environment. One of the means of expression are events whose activities engage local residents, visitors, guests, tourists, and, of course, distant spectators by means of smart global technologies. Cultural activities manifest by implementing cultural projects of various areas, starting from one-time local events, and ending with large-scale international projects. Cultural tourism is a great opportunity of urban and regional tourism development. Implementation of cultural events in cities can have impact on cultural tourism development and its planning, and can be one of the very important economic as well as sociocultural impact of tourism that manifests by created infrastructure, increasing supply of services and entertainment, and lively cultural life in cities. The work is relevant because it reveals for the first time how mega cultural events in cities are or can be an effect for cultural tourism development in cities.
Clinical and Histopathological Findings in Patients with Follicular Dermatoses: All Skin Diseases Starts in the Hair Follicles as New Hypothesis
Background: Follicular dermatoses are group of skin diseases characterised by follicular lesions during the course of the disease. Objective: To gather all skin diseases where there is follicular lesions to be evaluated in order to reach the hypothesis that hair follicles are the most principal target area in the etiopathogenesis of these skin disorders. Patients and Methods: This is a descriptive, clinical and histopathological study that was carried out at the Department of Dermatology, Baghdad Teaching Hospital, Medical City, and Baghdad, Iraq during the period from November 2018 to August 2019. Sixty patients with different follicular dermatoses were enrolled and all socio- demographic data related to the disease was obtained from each patient, in addition to physical examination was performed for each patient. Biopsies were taken from 40 patients, for histopathological evaluation. Results: Sixty patient, were included in this study, 35 patients males and 25 patients females with male to female ratio 1.4:1. Their ages ranged from 1-80(30.2 ± 16.96) years. All patients had follicular lesions. The histopathological results showed: perifollicular lymphocytes, follicular invasion and degeneration, follicular plugging, fibrous tract remnant, perifollicular melanophages and absent melanin pigment in the epidermis of patients with vitiligo. Conclusion: The result of the present study showed that all skin diseases start in the hair follicles and might spread to involve the proper epidermis, and the lesions could be microscopic or visible to the naked eye. The hair follicles have many anatomical and immunological privileges that make it easy to be an early target for any cutaneous pathological process. Hence these findings are in support of new hypothesis that say: all skin diseases starts in the hair follicles and then spread to attack the adjacent proper epidermis
The Need for Pre-retirement Vocational Education Training for Workers in Tertiary Institutions in Ekiti State, Nigeria
This study examined the need for pre-retirement vocational education training for workers in tertiary institutions in Ekiti State. Descriptive research design was used for this study. The population of the study was 9,523, made up of academic and non-academic members of staff in the four public tertiary institutions in the state. Five per cent (5%) of the total population was used as the sample for the study using proportionate sampling technique. Thus, the sample for the study was 476 members of staff. A set of questionnaire titled “Questionnaire on Pre-retirement Education Training for Tertiary Institution Workers in Ekiti State (QPETTIW) was administered on the respondents. All the administered questionnaires were returned, mean and standard deviation were used to answer the four research questions. The finding revealed that there were economic, social and psychological needs for pre-retirement vocational education training for workers in public tertiary institutions in Ekiti State. Thus, it was recommended that institutional authorities should incorporate pre-retirement vocational training/education into their staff development programme, among others.