Human lung cancer is the most prevalent cancer worldwide that consisting of two main subtypes: the non-small cell lung cancer (NSCLC) and the small cell lung cancer (SCLC). NSCLC comprises over 80% of lung cancer and the treatment of NSCLC is mostly guided by tumor stage, although distinctive molecular characteristics between two major subtypes of NSCLC, i.e., lung adenocarcinoma (LUAD) and squamous cell lung carcinoma (LUSC), have been increasingly identified. In this study, we integrated the gene expression data and methylation data to investigate the genetic differences between LUAD and LUSC. We further applied the Boruta package to select key features from LUAD and LUSC tumor samples to build predictive models of tumor stage. We finally obtained 6 key gene expression features and 4 key methylation features that can be reliably used in prediction of LUAD and LUSC stage.
Cause analysis and treatment of acid wastewater pollution in xiayuanqiaotou coal mine of Kaili City, Guizhou Province
In this paper, the acid wastewater pollution caused by the closed pit of xiayuanqiaotou Coal Mine is taken as an example. Through hydrogeological survey and field inspection, the geological and hydrogeological conditions of the study area are understood, and the cause and discharge of acid wastewater pollution in the mining area are analyzed. The results show that the goaf and coal gangue leaching water formed by the disorderly mining of small coal kilns in the Yudonghe Vally are the main sources of acidic wastewater pollution, and direct drainage from the mine mouth is the main drainage method of pollution in the Yudong Vally.Based on this, the technology of source control plus terminal treatment has been adopted, and applying regional water treatment and prevention technology to treatment is a new model of both specimens and treatments.which will play a significant role in the treatment of acid mine water in Guizhou and the south in the future.
Cash flow ratios are the ratios are calculated using balance sheet, income statement, and the statement of cash flow. The statement of cash flow is used to calculate all of the 28 cash flow ratios. These ratios may be used in financial management. The financial managers can utilize the ratios in especially the seven functions of the financial management. They are financial analysis, working capital management, capital structure, capital budgeting, dividend policy, leverage, and valuation. All of the cash flow ratios could be used financial analysis and working capital management functions of the financial management. 14 ratios in capital structure, 10 ratios in capital budgeting, 8 ratios in dividend policy, 8 ratios in leverage, and a ratio in valuation may be used.
MINI-THORACOTOMY VERSUS FULL STERNOTOMY TECHNIQUES IN MITRAL VALVE SURGERY: BLOOD LOSS, WOUND INFECTIONS, POST-OPERATIVE RECOVERY, MORBIDITY AND MORTALITY INVESTIGATION
Background: Mitral valve surgery is routinely performed through a Median full sternotomy (MFS) with excellent long term outcomes. Minimally invasive mitral (MIMVS) valve surgery is also a surgical approach that improves operative outcomes. In this study we report early post-operative outcomes in minimally invasive mitral valve surgery compared with MFS access with reference to Blood Loss, Wound infections, post-operative Recovery, Morbidity, Mortality and others variables. Patient and Methods: This study was a prospective data collection from 52 consecutive patients who underwent isolated mitral valve surgery at our institution from November 2017 to October 2019. Population study was divided to two groups, MIMVS (group I n= 26) and MFS (group II n=26). Pre-operative planning were performed so that to obtain similar characteristics. Intra and post-operative data were analysed. Results: The baselines characteristics were similar in both groups. Of the 26 patients in group I, 23 (88.46%) underwent mitral valve replacement and 3 a mitral valve repair. All the patients in group II underwent mitral valve replacement. There was no difference in term of mortality and morbidity. MIMVS was associated with longer CPB time (mean 161.9 vs 89.8 mins, P =.025) but similar ACC (99 mins vs 64 P=.468) time. MIMVS Patients had likely lower incidence of red blood cells transfusion (12.2% vs 34.7%,), post-operative haemoglobin was similar before transfusion. Haemorrhage complications were more likely in the group II (26.08 vs 7.7%); requiring inotropic support was found to be higher in the group II (54.5 vs 19%). In addition, patients in the MIMVS group had a shorter mechanical ventilation time (1.6 [1-6] vs 3.6 [2-8] hours; P
Inadequacy of rock mechanics chamber test devices and test systems that cannot accurately simulate gradient static stresses on specimens, this paper presented an innovative testing technique, which relates to the stress wave propagation of rock subjected gradient static stress. The method involves modification of a split Hopkinson pressure bar, such that the test specimen is subjected to gradient static stress and axial impact loading. The device has the features of simple loading and multiple static stress gradients, which verifies the feasibility of stress wave propagation test of red sandstone specimens under linear gradient static stress and conducts stress wave propagation test of red sandstone specimens under linear gradient static stress. Tests on red sandstone specimens with different static stress gradients show that the stress wave propagation of the specimens under gradient static stress is different with their corresponding homogeneous static stress state. The attenuation coefficients of stress waves are different under different conditions, and loading gradient static stress can accelerate the attenuation process. The results of this study will be useful for the analysis of stress wave propagation in deep engineering blasting and the stability analysis of adjacent structures.
Aim: Facial lipostructure (FLS) is not a new procedure. In the past, many surgeons steered clear of it because the results were poor and unpredictable . In the 80’s however FLS emerged with precise indications, improved techniques, foreseeable and stable results. Its use has become widespread because it produces natural, long-lasting outcomes with minimal donor site morbidity . FLS usually represents the last procedure or retouch in many reconstructive procedures and protocols. Moreover adipose-derived stems cells (ADSCs) represent a promising source of autologous cells for tissue repair and regeneration. Methods: In the maxillofacial area, FLS is indicated primarily to restore and rejuvenate the zygomas, periorbital region, cheeks, nose, lips, chin, mandible and jawline. Recently, it has been applied to correct localized tissue atrophy, burns, hemifacial atrophy (Parry-Romberg syndrome, scleroderma, anophthalmic orbit), and loss of substance resulting from trauma, tumor excision, and congenital craniofacial deformity sequelae. Orthognathic surgery and fat grafting represent a new application and an appropriate indication. It is well known that this surgery moves the skeletal bases (maxilla, mandible, chin) but often this leads to a lack of soft tissue coverage. Some patients, particularly women, complain about this lack of soft tissue volume after bony surgery. Conclusion: FLS was launched as a means to improve volumes and facial aesthetics. Recently, it has been applied in more complex reconstructive and regenerative procedures. It can especially be used on any facial area lacking soft tissue due to posttraumatic outcomes, post tumor deformities, and as a refinement in for many acquired and congenital maxillofacial deformities. The proposed uses for ADSCs in tissue repair and regeneration are quite impressive. Recent works on ADSCs would suggest that adult cells may prove to be an equally powerful regenerative tool in treating congenital and acquired maxillofacial disorders. More importantly, physicians, researchers and international associations need…
THE FEASIBILITY OF EARLY CLOSURE OF DEFUNCTIONING LOOP ILEOSTOMY AFTER LOW ANTERIOR RESECTION FOR RECTAL CANCER
Background: The advantages of defuctioning loop ileostomy in some cases of rectal carcinoma is not questionable, but many patients experience serious stoma related complications and impaired quality of life. Early closure of the defunctioning ileostomy could mitigate these problem. Methods: This is a controlled randomized study done on 100 patients suffering of rectal cancer who had low anterior resection of the rectum and covering ileostomy at Menofiya University Hospital between April 2016 to august 2019. The patients were randomly divided (by closed envelope method) in two equal groups, Group A (Early group) and Group B (Late group). Results: As regards the pre-closure ileostomy complications: skin infection and maceration occurred in 4 pts. In early group and in 15 pts.in late group while dehydration and electrolyte imbalance occurred in 3 pts. In early group and in11 pts. In the late one, with both complications were significantly higher in late group (P value; 0.009 and 0,04 respectively). The health related quality of life was found to be higher in early group at 2 and 6 months than that in late group, but this did not yet reach significant difference, and at 12 month, the results were almost the same. Conclusion: Early ileostomy closure is safe, and not associated with higher complication rates in patients with an uncomplicated postoperative course and radiologically verified intact distal loopogram study.
The epidemiology of Alzheimer’s disease (AD) is notable. North America and Western Europe have the most expressive rates of disease (6.4% and 5.4% at age 60), followed by Latin America (4.9%) and, finally China (4%). The most important fact is that head trauma increases the deposition of amyloid βeta (Aβ) and the expression of neuronal tau as well as diabetes. Obesityand trans fats also increase the risk of AD. However, virtually no current pharmacotherapy is approved for agitation / excitation caused by AD, the only purpose is maintaining the memory of those affected by this disease. There is substantial evidence that some dysfunctions in the mitochondria are involved in AD. Mitochondria are essential for neuronal function because the limited glycolytic metabolism of these cells makes them highly dependent on aerobic oxidative phosphorylation (OXPHOS) for their energy needs. Increased concentrations of ROS are known to result in molecular damage to the site where they are produced, triggering what science calls oxidative stress. Another no less important pathophysiological process in neurological disease is mitochondrial membrane cholesterol. New evidence indicates that the burden of mitochondrial cholesterol can influence mitochondrial function regardless of its conversion to pregnenolone or oxysterols, emerging as a key factor in the pathology of several neurological diseases associated with mitochondrial dysfunction, as in the case of AD. In this way, neurons are strictly dependent on the presence of healthy mitochondria, especially in the synapses where these organelles produce ATP and concentration of Ca2 + ions, fundamental processes for the implementation of neurotransmission and generation of membrane potential along the axon. Controlling ROS, as well as reducing the inflammatory cascade in neurons can be a good strategy in controlling the disease. The reduction of cholesterol in the external mitochondrial membrane may be another interesting path for the reentry of glutathione in…
Balance is a functional activity that must be implemented in every type of rehabilitation for the back and lower extremities’ injury and pathology. With issues in these regions, balance is lessened, requiring exercises that enhance the patient’s stability. Purpose: To determine the impact of activities on a rotating balance platform with tracking tasks for lower limb muscle activation. Method: Twenty-five participants performed seven tasks on a balance board with a fixed middle fulcrum. For each trial, activation of the gastrocnemius and tibialis anterior muscles was recorded using surface electromyography. Upon examination of the EMG data, the following variables were quantified: time to peak muscle activation, time to decay of muscle contraction, and time of muscle contraction duration. Results: A repeated measures ANOVA revealed that TA exhibited significant modifications (P
OBSERVATIONS OF PERFORMANCE AND BODY COMPOSITION FOLLOWING 8-WEEKS OF PROGRESSIVE RESISTANCE TRAINING IN PARTICIPANTS WITH CEREBRAL PALSY
Purpose: To observe the effects of progressive resistance training on performance and body composition in participants with cerebral palsy. Methods: Four quadriplegic (3 male, 1 female) and two hemiplegic (2 female) participants (22 ± 5 yr, mean ± SD) completed moderate to high intensity resistance training 2-3 days a week for 8-weeks. Strength training programs were developed for each participant based on their physical ability. Measurements of exercise performance and body composition (InBody 270 & S10) were collected prior to and following training. Data from all participants was pooled, and samples with 5-6 subjects were analyzed using a paired t-test with significance set at p < 0.05. Results: Measurements of muscular fitness improved, including plank performance (pre: 64 ± 40, post: 95 ± 61 s, n = 6), supine sled leg press 1RM (pre: 225 ± 69, post: 378 ± 124 lb, n = 6) and bench/sled press 1RM (pre: 92 ± 54, post: 115 ± 58 lb, n = 5). There was no change in peak sprint capacity (pre: 89 ± 32, post: 96 ± 29 W, n = 5) or peak aerobic capacity (pre: 303 ± 136, post: 370 ± 246 s, n = 4). Measurements of body weight (pre: 151 ± 40, post: 151 ± 42 lb, n = 6) and skeletal muscle mass (pre: 53 ± 8, post: 54 ± 9 lb, n = 6) were unchanged following training. Conclusion: Preliminary data is encouraging that the unique and challenging strength training program employed with these participants can be utilized to gain meaningful improvements in muscular fitness. However, a larger sample size and longer training period may be necessary to significantly increase muscle mass.