During the ship’s voyage, the propeller jet affects the movement of silt at the bottom of the bed. To research the influence of the bottom boundary on the propeller jet field, this paper takes the standard propeller DTRC4119 propeller as the research object and uses the CFD software Star-ccm+ to carry out a numerical simulation of the propeller jet under uniform flow. The flow velocity distribution of the jet under four operating conditions is mainly analyzed, including the axial velocity, tangential velocity and radial velocity of the jet. The results show that the distance between the propeller and the boundary does not affect the magnitude and distribution of the velocity on the initial plane but affects the shape of the axial velocity and the velocity on the central axis in the development zone; The closer to the bottom boundary, the greater the disturbance of tangential velocity and radial velocity, the peak value of tangential velocity will be affected and changed from central symmetry of velocity to unanimous trend earlier. The radial velocity contributes less to the overall velocity and can be ignored
Study on the generalized model of the lateral frictional resistance distribution under the ultimate state of the bored piles based on stratum structure
Based on the results of the ultimate load distribution of the part of the bored piles in the vertical static load field test of single pile, combined with the analysis of the relevant piles and soil data, found that the lateral friction resistance distribution of the bored pile in the ultimate load state was mainly related to structure of the soil layer on the pile side. Based on this, the side resistance distribution mode of the pile under the ultimate load conditions is generalized into a trapezoid, wing-shaped, micro-arc, and “R” shaped. The lateral friction resistance of the pile is positively correlated with the hardness of the soil, and the depth, thickness can influence the pattern of distribution of lateral friction resistance.
On Valentine’s Day, the sight of couples holding hands and hugging each-other might unleash a wave of jealousy in those who are single. However, there might not be much to be jealous about. Also, marital quality clearly colors one’s overall sense of well-being, and marital distress elevates health risks, says a leading clinical psychology journal. However, the simple presence of a spouse is not necessarily protective; a troubled marriage is itself a prime source of stress, and simultaneously limits the partner’s ability to seek support in other relationships. The worst distance between two persons in a relationship misunderstanding. Indeed, the relationship between life satisfaction and marital quality is stronger than life satisfaction’s ties to either one’s job or one’s health.
Background: Stevens–Johnson syndrome (SJS) is one of the severe forms of cutaneous adverse drug reactions. Despite it is rare, SJS is highly weakening and life-threatening illness commonly occurs as a result of medications, which is characterized by fever and mucocutaneous lesions leading to necrosis and sloughing of the epidermis. Objectives: This case report professionally provide feedback on clinical practice guidelines, offer a framework for early signals of effectiveness, adverse events; and to share the case for medical, scientific or educational purposes. Methods: This is an observational type of case report which we observed in Arba Minch University Students’ Clinic during outpatient diagnosis. Discussion: Despite ciprofloxacin induced SJS had reported in different areas by different scholars with different duration on antibiotics, clinical manifestations, duration of recovery and complications; but itis the first report in Ethiopia. Conclusion: This case concludes that severe hypersensitivity reactions like SJS can be caused by ciprofloxacin use which can be potentially life threatening. Therefore, identifying medications causing SJS is of paramount importance to withdraw it immediately and for additional treatment.
The present study evaluated the effects of a branded Nigerian polyherbal formulation, Yoyo® bitters on the haematological and biochemical status of hydrogen peroxide (H2O2)-intoxicated rats. Thirty (30) healthy male Wistar rats used in this study were divided into 6 groups of 5 rats each. Group 1 served as normal control and received 3 ml/kg body weight (b.w.). of distilled water only while group 2 served as experimental control and was intoxicated with H2O2 without treatment. Rats in groups 3-5 were H2O2-intoxicated and treated with 1, 2 and 3 ml/kg b.w. of Yoyo® bitters respectively while rats in group 6 were H2O2-intoxicated and treated 100 mg/kg. b.w. of silymarin. H2O2 was administered intraperitoneal on day 0 while drugs were orally administered from days 0 to 14. The rats were sacrificed on day 15 and blood samples collected were subjected to haematological and biochemical analyses. Intoxication with H2O2 significantly (p < 0.05) induced haematotoxicity, oxidative stress and hepatotoxicity when compared with control. Treatment of intoxicated rats with the formulation restored the haematological and biochemical status to normal, suggesting that Yoyo® bitters has erythropoietic and hepatocurative effects. However, future studies are required to confirm these effects in different in vivo models.
Nature has always been a giver, bearing rich heritage of natural products which arebeing utilized by mankind since their existence. Azaraqi (Strychnos nux-vomicaL.) is a potential herb used for the treatment of various neuronal illness, muscloskeletol and joint disorders. This comes under category IV of drugs as per Unani literature which needs to be detoxified prior to clinical use.The healing properties of Azaraqi (Strychnos nux-vomicaL.) are substantially those of the alkaloids strychnine and brucine, which are considered toxic.The perception of lesser side effects of herbal formulation among the people especially in developing countries raised the market of treatment by natural products. However, there is need to put forward the scientific evidence of these formulation regarding toxicity as well as efficacy as then only evidence based medicine would only be able to make position in globalized world as an alternative of conventional treatment available. This review article will discuss the potential pharmacological actions; toxicity developed due to Azaraqiresulted out in different preclinical and clinical studies. The authors will try to make a suggestion for future based on finding of these studies.
Useful Anti-Cancerous & Anti-tumorous Asian medicinal Plants (Taxus baccata L. or Taxus baccata Thunb., Catharanthus roseus(L.) G. Don, Annona muricata L.)
Cancer is one of the harmful leading causes of death worldwide. Several synthetic agents have been used to cure the disease but they have their adverse side effects, low-hilling potential and toxicity.Present Article reviewed three important medicinal plants i.e.- Taxus baccata L. Or Taxus baccata Thunb., Catharanthus roseus(L.) G.Don and Annona muricata L. which traditionally used since ancient time for the treatment and prevention of Cancer and Tumor in Sothern, Northern-east and Himalayan region of India. Having active phytochemical constitutents Taxanes- Alkaloids(Taxol and Taxotere), Larotaxel,nab-Paclitaxel present in T. baccata L. Or T.baccata Thunb. and Vinca-Alkaloid as Vinblastine, Vincristine, Vinorelbine, Vinflunine, catharanthine and vindoline alkaloids in Catharanthus roseus(L.) G.Don, as well as Muricin J, Muricin K, Muricin L, Cinnamic acid derivative, Coumaric acid hexose, Annomuricin A, Annomuricin B, Annomuricin C, Annomuricin E, Annomutacin, Annhexocin, Muricatocin A, Muricatocin B, Muricatocin C, Giganletronenin, Annonacin A, Annopentocin A, Annopentocin B, Annopentocin C etc. present in A muricata L. This report also revealed the ethno-botanicaly and biological activities of active principles of these plants that will help in noval drug discovery, noval new active phytochemical constituents of anti-cancer and anti-tumor formulations and development of pharmacopial standareds.
Standardization is used to describe all measures under taken during the manufacturing process and quality control of drug assuring its reproducible quality. Most of the traditional medicine are effective but still they lack in its standard parameters. Therefore, we need to develop standard techniques to standardize and validate herbal formulations. The drug Habb-e-Sara Khas is therapeutically useful in the treatment of Sara Khas (Epilepsy and Infantile epilepsy). The drug Habb-e-Sara Khas was prepared in three different batches as per the guidelines of National Formulary of Unani Medicine(Part-VI), Present study is aimed to evaluate the pharmacopoeial standards using physico-chemical parameters; HPTLC fingerprints, quality control and assurance parameters, using WHO guideline to ascertain the quality of drug. The physico-chemical data showed that the drug contain moisture(1.89%), total ash (5.43%),acid in-soluble(1.06%), alcohol and water soluble extractive matter (19.39%) and(60.34%),pH(1% solution) (5.93),pH(10% solution)(5.67), ASSE(18.07%) and CSSE (17.43%), Bulk density of granules(0.4989) and the TLC/HPTLC finger prints showed various spots at 254nm, 366nm and visible light (V-S reagent). The quality control study revealed the absence of microbial load, aflatoxins, heavy metals and pesticide residues, The evaluated standards will very much useful for laying the phamacopoeial standards of Habb-e-Sara Khas and also in providing the quality medicine to needful human beings.
Preparation and characterization of curcumin-loaded silica nanoparticles and their in-vivo anti-cancer activity evaluation
Curcumin [(1E,6E)-1,7-bis (4-hydroxy- 3-methoxyphenyl) -1,6- heptadiene-3,5-dione)], a polyphenolic compound derived from dietary spice turmeric, has numerous biological and pharmacological activities. It is currently being used for treating several disorders, including cancer. Keeping in view its importance, the curcumin was embedded in the silica nanoparticles prepared by reaction of Tween-40, n-Butanol, triethoxyvinylsilane and 3-aminopropyltriethoxysilane using water as solvent. After completion of reaction, the nanoparticles were obtained by dialysis of the reaction mixture. The nanoparticles were characterized by SEM, TEM, DLS and XRD analyses. The SEM, TEM and DLS analysis shows the average particle size to be 70nm, 66 nm and 75.72nm respectively. Further in-vivo studies were conducted on wistar rats to determine the maximum tolerance dose (MTD) of nanoparticles and study the anti-cancer potential by tumor regression analysis. The MTD was found to be 10 mg/kg body weight of wistar rats and curcumin-doped ORMOSIL nanoparticles in comparison with pure curcumin revealed the highly significant results in tumor regression in EAT induced tumor model.
Yoruba traditional healing system has being in practice for several centuries, yet, there are still certain complexities which set confusion in understanding its conceptualization. Due to lack of enough information about the practice, cynicism, religious bigotry against the practice and over-westernization of healthcare system in Yoruba society, basic features of Yoruba traditional healing system are still obscured. Conceptualization of the healing is narrowed and reduced to fetish; its epistemology is linked with Satan, and organization of Yoruba traditional healing is regarded as unscientific among other complexities suffered by the healing system. This continues to hamper the acknowledgment of its contributions to sustainable healthcare development. Through ethnographic data collection techniques using key informants’ interviews, observation, case study analysis and ethno-botanical survey conceptualization of traditional healing in Yoruba worldviews is examined. Despite the wave of social change influencing the practice of healing in Yoruba society, Yoruba traditional healing system is still resilient, rational and scientific. It features organization of service, providing all- inclusive health caring; with professionalization and specialization in health care service. Since Yoruba healing system is indigenous to the people, it has to be sustained by providing enough information that can explain and contextualize its practices.