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  • Gestacional Diabetes Mellitus (GDM)

    The existence of different types of diabetes contributes to a varied therapy, conditioned to the advance that this pathology is. In Gestational Diabetes Mellitus this condition is no different. In this context, this chapter will address Gestational Diabetes Mellitus, as well as its risk factors, prevention and consequences of this pathological condition.

  • Recurrence of Graves’ disease in thyroid remnant after total thyroidectomy

    Recurrences of Graves’ disease (GD) after total thyroidectomy (TT) are uncommon, with few cases reported in literature. This article describes the case of a 58-year-old man who was treated with TT due to GD over 15 years ago. A progressive reduction of levothyroxine treatment was observed due to persistent subclinical hyperthyroidism. Thyroid-stimulating hormone receptor antibodies were detected in blood analysis and in the imaging test, a lesion was identified in the upper left anterolateral cervical region. A histopathological study of the lesion revealed colloid goiter. The patient was diagnosed with GD recurrence in a thyroid remnant and was remitted to an otorhinolaryngologist to remove the lesion. The histopathological study showed diffuse thyroid hyperplasia. The objective of this clinical case report is to highlight this unusual recurrence to better treat and improve long-term outcomes in patients treated with TT.

  • PHYSIOTHERAPY APPROACH IN MICROCEPHALY PATIENTS

    INDRODUCTION: Microcephaly is a neurological condition with a craniofacial anomaly where it has a reduced cephalic perimeter, resulting in malformation of the central nervous system. In 2015, Brazil registered an outbreak of the disease, mainly in the states of northeastern Brazil, causing a state of alert in the entire population and a problem for public health that after investigative studies, concluded that the responsible for the outbreak would be the Zika virus. In general, the disease may present a delay in the neuropsychomotor development, the application of an early intervention program should be done in a systematic and individual way, respecting the various changes in each case. With the physiotherapist applicability occurs the contribution with the physical and psychic benefits, creating more possibilities for psychosocial rehabilitation. OBJECTIVE: To show the approach of physiotherapy to minimize the impairment caused by microcephaly, through appropriate treatments mediating the disability of each individual. METHODOLOGY: For this summary, a study was made on the need for physiotherapy in patients with microcephaly. It was conducted by electronic research in the databases Scielo, Pubmed and Bireme RESULTS: Microcephaly is a pathology that causes severe functional and cognitive alterations, being important the rehabilitation with purpose the stimulation of the child according to the neuropsychomotor age. The conduct of any technique in the first years of life helps in the process of maturation of the central nervous system, being considered important for the development of motor, cognitive and sensory skills. The study demonstrated that in addition to early interventions, the care with an interdisciplinary health team and the support of the family environment favors the development and functionality leading to the autonomy and independence of the child. CONCLUSION: Microcephaly is a pathology that requires continuous treatment for the rest of life. The early stimulation through a conduct with kinesiotherapeutic…

  • Prepyloric Diverticulum in a Nigerian: Case Report of a Rare Finding

    Diverticulae are uncommonly encountered in the stomach. They can be congenital or acquired- the latter variety being the less frequent of the two. This article details one such rare case from Lagos, Nigeria and discusses certain aspects of its clinical and endoscopic presentation. We present a 59-year old with a background history of non-steroidal anti-inflammatory drugs abuse presented with hematemesis and melena and was in hemorrhagic shock. After stabilization, the gastroscopy findings were of a gastric diverticulum (GD) in the anterior prepyloric wall. There was a Forrest IIb ulcer in the GD’s wall with surrounding erythema and edema. The patient was successfully managed medically and conservatively and with good long term results.

  • Homocystinuria a rare cause of low BMD in young patients: A case report with literature review

    Background: Homocystinuira is a rare autosomal recessive disorder in the metabolism of sulfur-containing amino acid caused by mutations in the cystathionine beta-synthase gene which encodes the pyridoxine (Vitamin B6) dependent enzyme cystathionine beta-synthase. It is characterized by significant elevations in plasma and urine homocysteine concentrations, which could be associated with increased risk of fracture. Methods: We describe a case of Homocystinuria who suffered from a low impact patellar fracture with a literature review to highlight the critical relationship between homocysteine level and bone health. Results: We reported a 36-year-old female with a diagnosis of Homocystinuria due to pyridoxine (B6) unresponsive severe Cystathionine Beta-Synthase deficiency. After a minor knee injury she developed a right patellar fracture and her X-ray revealed osteopenia. On examination, she has severe scoliosis in the spine with bilateral aphakia (absence of the lens of the eye). Her labs showed, persistent high Homocysteine above 100 umol/L, Methionine: 383 umol/L (10-42), Vitamin D 12 ng/ml. Her spine X-ray revealed very severe scoliosis with osteopenia but no vertebra fracture. Her DXA scan showed her Z-Score was within the expected range for her age in hip, spine and 1/3 radius areas, however her ultra-distal radius Z-Score was -4.0. Her Homocystine level was mostly higher than 100 due to non-compliance with dietary advice and treatment. High homocysteine levels in Homocystinuric patients impair the function of bone cells that regulate bone remodeling as well as bone material properties such as collagen cross-linking. This imbalance between bone formation and resorption may lead to a low BMD and fracture in patients with homocystinuria. Interestingly, even in general population hyperhomocystinemia with a plasma level of more than > 13 nmol/ml has been found to be associated with low BMD and an increased risk of fractures that is independent of BMD. Deficiencies in vitamin B6, B12, or…

  • Single-cell transcriptome analyses profile tissue macrophages in the human osteoarthritis

    Osteoarthritis (OA) has long been considered as a degenerative disease, but growing evidence suggests that inflammation plays a vital role in its pathogenesis. Unlike rheumatoid arthritis and other autoimmune diseases, inflammation in OA is chronic and in relatively low-grade, mainly mediated by the innate immune system, especially macrophages. However, due to its low abundance, there is a lack of systematic studies on macrophages in the OA condition. Here, we have used single-cell RNA sequencing analysis to gain insight into the heterogeneity and functional specialization of human knee macrophages. We also compared the gene expression profiles of macrophages in healthy people and OA patients, and found the characteristic changes of special macrophages in the OA knee. We believe that this in-depth understanding of the basis of OA inflammation will bring hope for the development of new therapies.

  • Homeopathic treatment for Female infertility

    In this review article the writer contends that homeopathy is best effective methodology in barrenness of female’s Nowadays greater part of couples are deferring pregnancies for 1 to 2 years after marriage and subsequently when they are arranging pregnancy, around one fourth of them face issue in considering. Presently clinical field is a lot of cutting edge and bring to the table a ton in fruitlessness, similar to astute homeopathy is a most current framework which can fix the malady from the root, Homeopathy depends on side effect likeness and by sacred medication we can even treat barrenness of obscure etiology likewise, Here an endeavor is made to pass on the methodology of homeopathy in fruitlessness and its regular causes.

  • The Impact of China’s Prohibition of Importing Solid Waste on the World Economy Based on Autoregressive Model

    To explore the impact of China’s ban on the import of solid waste on the world economy and the environment. In this paper, a VR autoregressive model based on time series was established. India, Malaysia, the United States, and Japan were selected as countries affected by China’s ban on waste imports to replace the impact on the world. The GDP and CO2 emissions of various countries are used as indicators to measure the economy and the environment. By predicting the data that China has not implemented the ban on the collection of imported waste and comparing it with the data after the actual implementation, it was found that: after the promulgation of the policy, the environmental quality of the major importing countries declined and the economy increased. The economic impact of the significant solid waste exporting countries is not apparent, and environmental pollution increases slightly.

  • Modernization strategies and agricultural development in Senegal: A model for policy analysis

    Since independence in Senegal, the agricultural sector has been considered the vanguard of development. With this intention, sector development strategies at a cost of billion dollars have been formulated around technical, economic and social axes. The technical axis consisted of introducing agricultural equipment and infrastructure, rebuilding the seed bank, and improving hydraulic management. The economic axis involved developing a formal credit system and new marketing systems. The social axis stressed new production units and professional associations. The results of these strategies of intensification, improved profitability, and producer organization remain limited and Senegalese agriculture continues to experience cyclical crises. Why don’t these strategies of modernization achieve the expected results? What strategy is needed to modernize and develop agriculture in Africa, and particularly in Senegal? To answer these questions, we introduce an analytic framework based on a study of over 50 years of Senegalese agricultural policy and practice (Ndiaye, 2013). This framework provides new policy insights by more clearly distinguishing between development strategy components, actors and consequences.

  • Dementia syndromes and health psychology

    The aging process is considered a worldwide phenomenon, and it is observed that the population has aged, where there is an inversion in the age pyramid resulting from the increase in life expectancy. This phenomenon has been investigated by several national and international studies. As results, there are some justifications that are being cited. Among these, are the presence of some demographic factors such as a reduction in fertilit, fecundity and mortality rate over the years, in addition, we highlight the technological advances in health and improvement in the quality of life of individuals1,2. Consequently, with the presence of these influencing factors, some studies highlight an epidemiological transition, where infectious diseases are being replaced by chronic-degenerative, as the main cause of morbidity and mortality, giving emphasis on dementia syndromes . In addition of aging, are expected physical, psychological and social changes that lead to changes in the life of each elderly. At this stage of life, in addition to chronic conditions, the decline in cognitive functions, such as changes in memory, speed of reasoning, and attention seem to take on a broader dimension. Thus, with the decline of these and other functions, several difficulties can be observed in the execution of activities of daily living of the elderly, implying difficulties in their “coming and going”, that is, in their autonomy and self-care.