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  • Effectiveness and Safety of Apatinib Mesylate Tablet in the Treatment of Advanced Solid Tumors

    Angiogenesis is the most critical step in the development and progression of malignant tumors. Anti-tumor angiogenesis has become the most promising new strategy for tumor treatment. Rapidly growing tumor cells secrete a variety of vascular growth factors under hypoxia to stimulate tumor angiogenesis. One of the important growth factors is Vascular Endothelial Growth Factor (VEGF). Some small molecule compounds that inhibit VEGFR have been used to treat Tumors. In this study, we evaluated the effectiveness and safety of Apatinib Mesylate tablet in the treatment of advanced solid tumors. We found that Apatinib Mesylate tablet can treat advanced solid tumors.

  • Successful use of a novel biological plug in the percutaneous treatment of a refractory gastro-cutaneous fistula following omental patch repair of perforated peptic ulcer

    Background: Gastro-cutaneous fistula following re-leak of omental patch repair of perforated peptic ulcer is a very rare but challenging surgical complication. We describe the use of a novel biological plug as a viable repair for gastro-cutaneous fistula that failed medical, endoscopic, and operative management. Additionally, we present a thorough literature review of reported cases of gastro-cutaneous fistulae following omental patching of peptic perforations to further highlight their treatment challenges. Summary: A 69-year-old man underwent repair of a perforated pyloric ulcer with a pedicled omental patch. After one week, patient developed a re-leak from the omental patch, and underwent a second laparotomy with repeat omental patching of the gastric perforation. Ten weeks after the second operation, the patient developed a gastro-cutaneous fistula that failed conservative management with nil per os and enteral nutrition delivered distal to the fistula site; multiple image-guided percutaneous attempts at fistula closure by interventional radiology via fibrin sealant injection and collagen-based vascular closure device; and endoscopic clipping by gastroenterology. Ultimately, this refractory gastro-cutaneous fistula was closed with a novel biological plug (Biodesign® Enterocutaneous Fistula Plug, Cook Biotech). Conclusion: Gastro-cutaneous fistulae following omental patching of perforated peptic ulcer represent a significant complication requiring a multidisciplinary management approach. The Biodesign® Enterocutaneous Fistula Plug offers a promising new tool for the non-operative treatment of refractory gastro-cutaneous fistulae.

  • Immunotargeted Monotherapy by Anti-PD-1 in Patients with Primary Non-small Cell Lung Cancer

    The 5-year survival rate of advanced non-small cell lung cancer is less than 5%. In recent years, immunotherapy represented by PD-1 antibody has become the standard treatment recommended by many lung cancer guidelines. With the treatment, the total survival time and quality of life have been significantly prolonged in patients with advanced Primary non-small cell lung cancer (NSCLC). In this study, the domestic anti-PD-1 monoclonal antibody, Camrelizumab, combined with chemotherapy was used to treat advanced non-small cell lung cancer. The efficacy of Camrelizumab and occurrence of cutaneous capillary hyperplasia (CCEP) were analyzed.


    Introduction: Eating disorders are psychiatric disorders that lead to biopsychosocial impairment with high rates of morbidity and mortality in the population. The prevalence of eating disorders in college students is quite significant, especially in health and female courses, associated with poor diet, and the influence of the media on the perfect body, becoming a social problem and public health that should be addressed in the daily lives of health professionals. Objectives: Analyze in literature the risk factors in college students for eating disorders. Methodology: The research took place in the CAPES Periodicals, PubMed and VHL Regional Portal. Descriptors were the terms: “Eating Disorders and Food Intake”, “Risk Factors” and “Students”. Articles published between 2014 and 2018 were included. Results: Of the 3287 articles found, only eleven were included in the review. Evidence was found that eating disorders may result from personal body perception associated with poor diet and excessive alcohol consumption. It can be expressed through the personal need to satisfy the physical image with the psychological, almost always unreachable. Evidence was also found that eating disorders are associated with higher parental education, living in urban areas, eating outside the home and the first two years after college entry. Conclusion: The literature on the interaction between eating disorders and risk factors is still incipient to the detriment of the complexity and scope of the phenomenon. It is also highlighted the need for further investigations on diagnostic and therapeutic teaching strategies of health professionals in order to reduce the morbidity arising from these events.

  • Patellar tendon rupture in a young adolescent post-Heterotopic Ossification – Uncommon presentation

    Background: Heterotropic ossification is a common entity, but in a young adolescent causing patellar tendon rupture is rare. Case description: A 13-year-old male presented to us with knee pain and inability to extend since six weeks following trivial trauma. Preliminary radiological investigations revealed a high riding patella with ossification in the patella tendon. The magnetic resonance scan confirmed the same with patellar tendon disruption and heterogenous ossification. He underwent surgery with patella tendon repair, augmentation with autograft and had complete recovery at six months follow-up. Conclusion: Heterotropic ossification caused by repetitive trauma leading to disastrous effects.


    Introduction: In 2014, the Family Health Support Center participated in an event among children, adolescents with disabilities and their caregivers, where they receive treatment and follow-up at the Rehabilitation Center in the municipality of Messias, state of Alagoas. In this event, the mothers asked the professionals for individual and group care for them, justifying that the caregivers needed professional follow-up in the face of social and emotional overload. This year the nomenclature that was the group of mothers of children and adolescents with disabilities became a group of caregivers of people with disabilities opening inclusion for all caregivers in the municipality and also aiming at the reports of professionals from the Family Health Teams and the Center for Psychosocial Care who shared the concern with the increase in care for caregivers who have been getting ill mainly involving psychological issues. Objective: To develop actions that stimulate the strengthening and self-care in its biopsychosocial aspects, improving the quality of life and providing the consolidation of family affective bonds. Methods: This work is being carried out from the treatment of qualitative data, being an action research, descriptive and bibliographic, whose collection and collection of data occurred through conversation wheels and application of questionnaires, websites, journals and articles. Finally, it is of exploratory type, because it proceeds to provide greater familiarity with the problem that is established. Results: With the development of methods of Continuing and Permanent Education in Health, actions are practiced with strategies planned in the line of care, adding the support of the health care network so that it can be offered qualified and humanized services, thus improving the biopsychosocial and family aspects. Thus, it is remarkable that the objectives have been achieved according to shared reports and application of evaluation questionnaires in monthly meetings with caregivers. Conclusion: It is…


    Introduction: Belonging to sexual and gender minorities and being afro-descendent brings an intense burden to these individuals, because of the stigma strongly present in society. Therefore, it is necessary to practice activities that provide the well-being and quality of life, such as meditation. Objective: To report the experience of the extension project “The influence of the practice of meditation focusing on breathing in the signs and symptoms of anxiety in the afro-descendant LGBT population”, which was part of the “Nucleus of African-Brazilian Studies” of the University Federal de Alagoas. Methodology: This is a descriptive study, of the type of experience report. This extension project began in June 2018 and lasted until September 2019. The scholarship and collaborators were responsible for mediating the meditation meetings, which took place from Tuesday to Friday, both in the nursing school, as well as in the University Residence of the Federal University of Alagoas. Each participant was invited to attend a weekly meeting of meditation practice with focus on breathing, with three meditation blocks lasting 10min each, totaling 30min per meeting. In addition to the weekly meetings at the university, the participant received a meditation diary so that he could meditate daily at home, write down the difficulties encountered and the feelings experienced during the practice, in order to bring better results with the meditation routine. The research was approved by the Research Ethics Committee of the Federal University of Alagoas. Results: According to the records of the meditation practices made by the participants in the meditation diary, it was observed that, initially, they had a lot of difficulty in keeping the attention in breathing and other thoughts ended gaining space. However, with the course of the practices and the implementation of the meditative routine, there were feelings of lightness, tension relief, sleep improvement, concentration…

  • Necrotising fasciitis of the abdominal wall

    A 53 year old gentlemen, with a history of intravenous drug use, presented to the Emergency Department in septic shock with an acute abdomen. He had been recently treated with dalteparin for a deep venous thrombosis of his left leg. He was resuscitated with fluids and antibiotics, and cross-sectional imaging suggested a diagnosis of necrotising fasciitis of the abdominal wall. He was admitted to ITU, and a laparotomy, abdominal washout, muscle debridement and laparostomy was performed overnight. No bowel perforation or contamination was identified. Over the next few weeks he underwent multiple debridements, and a negative pressure abdominal dressing was utilised. After a prolonged rehabilitation phase he was discharged home to live independently. He is currently in discussion with the plastics team regarding reconstruction of his abdominal wall. We would like to stress the importance of consideration of necrotising fasciitis as a diagnosis in the context of a critically unwell and septic patient with a history of subcutaneous/intravenous medication usage.


    Introduction: Known as inflammation of the salivary glands, sialodenitis can be classified as acute, subacute or chronic. It has obstructive factors as its main causality concomitant with the rare occurrence of sialolithiasis. These, in turn, can have severe consequences such as salivary thickening, ductal ectasia and swelling, associated with pain in the affected region. It has an epidemiologically predilection for men and its diagnosis is made through imaging tests such as ultrasound and panoramic radiography as well as through the digit-palmar evaluation of the professional. Surgical exeresis has been studied as the best approach for these cases, avoiding loss of function or recurrence. Objective: To report the case of a 71-year-old female patient diagnosed by the Oral and Maxillofacial Surgery and Traumatology Service of the Federal University of Pernambuco of School Dentistry with sialolithiasis injury associated with chronic sialodenitis with fibrosis in the submandibular gland. Methodology: The methodology of the study was the search for articles on the subject, organization in a brief literature review and its comparison with the case report that was described. Results: The patient attended the service because she complained of increased volume in the right submandibular region and during anamnesis presented pain on palpation and presence of purulent secretion in the oral cavity. After analysis of the imaging exam, which resulted in well-defined radiopaque pathology in the right mandibular body region, the patient underwent general anesthesia for lesion excision. Postoperatively, the patient evolved without phlogistic signs and after 1 year showed perfect healing and absent recurrence. Conclusion: It is essential, based on the case presented, the good preparation of the Dentist so that the correct diagnosis and treatment choice corroborate for a better quality of life of patients with lesions that severely compromise their stomatognathic function.


    Introduction The dermoid cyst is a rare cystic malformation, classified as benign cystic teratoma. It is bordered by an epidermal-like epithelium, containing structures attached to its wall. These cysts originate from midline retained epithelial remains during the closure of the mandibular branchial arches and the hyoid bone. The prevalence in the head and neck region is low. They affect more young adults without a predilection for sex. Clinically, it presents as a swelling, of soft consistency upon palpation because it contains keratin remnants and sebaceous secretions inside. The lesion is usually about 2 cm in diameter. Surgical excision is the treatment of choice, with little risk of relapse. Objective To report the clinical case of a 16-year-old male patient who underwent cystic lesion excision in the ear region with a diagnosis of dermoid cyst. Methodology The methodology of the study was the search for articles related to the subject, organization in a brief literature review and its comparison with the case report that was described. Results A 16-year-old male patient, melanoderma, sought the Oral Maxillo Facial Surgery and Traumatology Service of the Federal University of Pernambuco of School Dentistry, reporting an increase in volume in the right postauricular region with approximately 3 years of evolution. On clinical examination, a well-circumscribed lesion without movement, soft to palpation and painless was observed. The patient underwent additional examinations and excisional biopsy under general anesthesia. The access started with an incision in the post-auricular region, followed by the myocutaneous tissue division until the lesion was visualized and soon after, the dissection of the adjacent tissues to the enucleation. Cauterization and hemostasis of the bleeding vessels were performed and suture to separate stitches with 5.0 mononylon thread. The surgical specimen was sent to the Anatomopathology Service of the Clinical Hospital of the Federal University of…