Global Journal of Molecular Biology


Modulation of plant extracts on the resistance of staphylococcus aureus strains to antibiotics

Research Article of Global Journal of Molecular Biology Modulation of plant extracts on the resistance of staphylococcus aureus strains to antibiotics Amaral, J. P. D.1; M agalhães,L. P. M. 2; Oliveira, C. V. J. 3; Lima, C. S.A. 4; R Yara, R. 4; Sena, K. X. F. R 5 1Student of the Biomedicine Course, UFPE; 2Student of the postgraduate program in Pharmaceutical Sciences, UFPE; 3 Student of the postgraduate program in Biological Sciences, UFPE; 4Teacher/Researcher of the Department of Biophysics, UFPE. 5Teacher/Researcher of the Department of Antibiotics, UFPE Introduction:The increase in bacterial resistance has generated the need to increase research for the discovery of new drugs, and medicinal plants are a proven source of bioactive products with great therapeutic potential. Objectives: To analyze the modulating activity of the ethanolic extracts of cumaru, angico, artemisia, terramicina and espinheira in front of strains of Staphylococcus aureus. Methods: Modulating activity was determined by the disc diffusion method, analyzing three strains of multiresistant Staphylococcus aureus with the antibiotics erythromycin, vancomycin, clindamycin, oxacillin, gentamicin, chloramphenicol, cipropofloxacin and cefoxitin. Each antibiotic disk was soaked with 20μL of the extract. The disks were placed on the surface of the culture medium already seeded with the microorganisms and incubated at 35 ° C for 24 hours. The diameters of inhibition halos (HI) were measured in mm and compared to those determined by HI of the antibiotics alone. The increase in HI diameter ≥ 2 mm, synergistic effect; antagonistic effect when the HI diameter was smaller than that of the isolated antibiotic; and, indifferent effect, when the increase in HI diameter <2 mm in relation to the antibiotic alone. Results and Discussion: The crude extracts evaluated were able to modulate the activity of different antibiotics of clinical use by means of synergistic, indifferent or antagonistic actions. For the UFPEDA ...

Use of Glutamine as Supplementation in Oncological Patients in Treatment That Present Mucosite

Review Article of Global Journal of Molecular Biology Use of Glutamine as Supplementation in Oncological Patients in Treatment That Present Mucosite Pinheiro, M. M.A 1, Silva, K. B. 2; Vila Nova Filho, S. L 3, Nascimento, G. S 4, Santos, J. P. O. 5 1Nutricionista graduada pela Unifavip DeVry, 2 Nutricionista Residente em Atenção ao Câncer e Cuidados Paliativos – ASCES UNITA, 3Nutricionista Mestrando no Programa de Pós-graduação em Saúde as Criança e do Adolescente do Centro de Ciências da Saúde- UFPE, 4 Enfermeira Residente em Atenção ao Câncer e Cuidados Paliativos, 5 Assistente Social Residente em Atenção ao Câncer e Cuidados Paliativos. Introduction:The treatment used in neoplasias, chemotherapy and radiotherapy, generate a series of side effects that undermine the prognosis of cancer patients. Aiming mainly at nutritional status and mucosal integrity, we found the need for prevention in cases of patients who present with mucositis during anti-neoplastic treatment. Objective: To carry out a systematic review of the available knowledge about glutamine supplementation in the treatment of mucositis in patients undergoing antineoplastic treatment. Method: This is a literature review, selecting articles published between 2013 and 2015, in the Medline and Lilacs databases through Pubmed, with the following descriptors: glutamine and radiotherapy, glutamine and cancer and mucositis. Results: Studies indicate that the tumors that most affect the nutritional status of patients are head and neck neoplasms, esophagus, digestive tract and lung. Considering that the side effects of antineoplastic agents, such as vomiting, nausea, diarrhea, xerostomia, increased basal metabolic rate and mucositis, trigger a decrease in food intake, Leading the patient to malnutrition and cachexia. Mucositis is a result of inflammation of the oral mucosa or gastrointestinal tract. Several studies have evaluated the use of glutamine supplementation during antineoplastic treatment, since it depletes it over time, being related to cachexia, loss of ...

Dr. Hala Abdel Wahab
Ph.D., Université de Paris-Sud, France, Associate Professor, Department of Plant Pathology Head of Lab. “Molecular Diagnostic of Plant Diseases” Faculty of Agriculture, Ain Shams University, Cairo, Egypt

Dr. Shahin Gavanji
Chairman of “WAMS National Council of Iran at World Academy of Medical Sciences (WAMS), Chairman WAMS Oncology Research Group of Iran, 3-Young Researchers and Elite Club, Khorasgan Branch, Islamic Azad University, Khorasgan, Isfahan, Iran, Department of Biotechnology, Faculty of Advanced Sciences and Technologies, University of Isfahan

Dr. Richa Madan Lomash
Research Fellow, Receptor Biology Unit (NINDS), NIH, Bethesda (MD), USA

Dr. Alessandra Pelagalli
School of Veterinary Medicine, University of Naples

Dr.Prakash.MMS.Kinthada
Professor, Department Of Chemistry, Sri Vidya Nikethan Engineering College.Tirupathi ,INDIA

Dr Jahwarhar Izuan Bin Abdul Rashid
Department of Chemistry & Biology, Centre for Defence Foundation Studies (CDFS), Defence National University of Malaysia

Dr. Omi Laila Majeed
Division of Basic Sciences and Humanities, Sher-e-Kashmir University of Agricultural Sciences and Technology

Dr. Mohammad Mehdizadeh
PhD of Weed Science, University of Mohaghegh Ardabili

Dr Amanjot Kaur Riar
Brigham and Women’s Hospital- Harvard Medical School, Department of Medicine, Harvard New Research Building USA

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1.Teixeira C.L; Picanço K.R; Silva F.J; Alves A.J; Souza Neto Júnior J.C.Hematological parameters and sorological detection of canine hemoparasitoses with SNAP 4DX.Global Journal of Molecular Biology, 2018, 1:5. DOI: 10.28933/gjmb-2018-05-1805 
2.Melo T.S; Oliveira C.V.J; Amaral J.P.D; Lima G.M.S; Sena K.X.F.R. To evaluate the antimicrobial potential of Streptomyces spp. J181 against clinical isolates of S. pyogenes.Global Journal of Molecular Biology, 2018, 1:4. DOI: 10.28933/gjmb-2018-05-1804 

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