Chronic Lymphocytic Leukemia, a Case Report

Chronic Lymphocytic Leukemia, a Case Report

Aurelian Udristioiu

Faculty of Medicine,Titu Maiorescu University, Bucharest, Romania

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Purpose of the presentation. The case presentation has as aim to describe the onset and evolution of a case of Chronic Lymphocytic Leukemia, (CLL), less common, which does not fit into the standard treatment criteria for malignant hemopathies.
Case description. The patient TA, female, 39 years of age, married, with 2 children, was admitted to the Emergency County Hospital of Targu Jiu in 2014, in the Internal Medicine Department for the Obstructive Chronic Bronchopathy with frequent coughing, night sweats, retrosternal pain. Clinical and ultrasound examination revealed splenomegaly, with spleen enlargement of 3 cm above normal diameters. The patient was also in the Endocrinology department with the diagnosis of Type II Diabetes and Grade III Obesity.
Laboratory results. Hemogram in 3 Diff revealed Hb = 14g / dL, Ht = 45%, Nr. Platelets of 275,000 / mm cub, but an increased number of Leucocytes, 117,000 / mm cub, and in the leucocyte formula from peripheral blood, the lymphocyte count was 80%, the absolute value being 9360. All biochemistry assays were in normal values, inclusive LDH = 375 md / dL, (N = 200-400 mg / d L. In the cytological examination of the peripheral blood smear stained with My Grunwald-Giemsa staining in the LPF 100 microscopy, was described the lymphocytosis with very small lymphocytes in high percent.
Conclusions; CLL onset occurs in a young female patient, contrary to the frequency of LLC in people over 65 years of age, especially in men. The normal baseline Hb, Ht%, Platelet counts in establishing the CLL diagnosis directly in stage I / II could be falsely positive due to the patient’s comorbidities with COPD and DZ type II and Obesity. Also low platelet counts in the final stage III / IV may be appropriate for the LLC disease stage or may be low due to applied chemotherapy.

Keywords: Chronic lymphocytic leukemia, p-53 protein, monoclonal antibodies from the CD receptor panel, CD38 receptor.

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How to cite this article:
Aurelian Udristioiu Chronic Lymphocytic Leukemia, a Case Report. International Journal of Case Reports, 2018 3:36. DOI:10.28933/ijcr-2018-10-0401


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