Case Report of International Journal of Case Reports
A Case Report of Warfarin Induced Coagulopathy and Upper Gastro Intestinal Bleeding
aDepartment of Pharm D, Bharat Institute of Technology and Krishna Institute of Medica Sciences – Pharmacy ,Mangalpally Ibrahimpatnam, Telengana 501510,India
Warfarin is an oral vitamin k antagonist prescribed to those patients for the treatment and prevention of venous thromboembolism. The major challenges to be faced during the therapy were a greater risk for both major well as minor bleeding, which makes the regular monitoring of INR (international normalized ratio) mandatory. Here we report a case study of 76 year old male who presented to institution with the complaints of bleeding from oral cavity due to consumption of conventional anticoagulant therapy. Patient was on anticoagulation therapy for paroxysmal atrial fibrillation since 2011. The blood investigation revealed anemia (Hemoglobin: 6.1g/dl). He was immediately transfused with packed RBC and fresh frozen plasma to replenish the body reserves. Prothrombin time (PT)/INR was reported undetectable and warfarin was withheld from the past medications and was restarted at INR therapeutic range. Furthermore this case highlights the need for a better communication by providing counselling regarding all aspects of medications as well as lifestyle modifications and also by giving patient information leaflets.
Keywords: Case Report, Warfarin Induced Coagulopathy, Upper Gastro Intestinal Bleeding
How to cite this article:
K.Swapna. A Case Report of Warfarin Induced Coagulopathy and Upper Gastro Intestinal Bleeding. International Journal of Case Reports, 2019 4:74. DOI: 10.28933/ijcr-2019-02-0305
1. Wolf PA, Abbott RD, Kannel WB. Original contributions atrial fibrillation as an independent risk factor for stroke: the Framingham Study. Stroke 1991;22:983–988.
2. Ridker PM, Goldhaber SZ, Danielson E et al. Long-term, low-intensity warfarin therapy for the prevention of recurrent venous thromboembolism. N Engl J Med 2003;348:1425–1434.
3. Ho CW, Ho MH, Chan PH et al. Ischemic stroke and intracranial hemorrhage with aspirin, dabigatran, and warfarin: impact of quality of anticoagulation control. Stroke 2015;46:23–30.
4. Ammar M, Hun GH, Stuart JC, John WE, Michael DE, Lars W, Martina B, Mandy F,Salim Y, Sam S. Management and Outcomes of Major Bleeding during Treatment with Dabigatran or Warfarin. Circulation, 2013; 128: 2325-2332.
5. David K, Trevor B, Campbell T, Henry W, David P, Caroline B, Steve K, Michael M British Committeee for Standards in Heamatology. Haemostasis and Thrombosis Task Force for the British Committee for standards in Haematology. Guidelines on oral anticoagulation; Third edition. Br J Haematol, 1998; 101: 374-387.