Case Report of International Journal of Case Reports A rare case of Rubinstein-Taybi Syndrome and gynecological malignancy Mahfooz, Faisal, Bartholomew, Chase, Franquemont, Stephanie, Mathew, Jr., Jacob; Parkview Medical Center, Department of Medicine Rubinstein-Taybi syndrome (RSTS) is a congenital syndrome most associated with mutations on chromosome 16p13.3 that can result in both benign and malignant neurologic and hematologic neoplasms of various primary origins. We present the case of a 39-year old female with RSTS who presented with severe abdominal and pelvic pain. Abdominal and pelvic imaging revealed multiple masses involving the uterus, liver and spleen concerning for malignancy. Biopsies from the endometrium and cervix confirmed this as a poorly differentiated, widely invasive squamous cell carcinoma. This represents the first case of primary squamous cell carcinoma of gynecologic origin in a patient with Rubinstein-Taybi syndrome. This case aims to raise awareness of the gynecological malignancy in patients with RSTS as well as serves as a reminder to clinicians to have a broad differential diagnosis in all patients which may help lead ...
Rubinstein-Taybi Syndrome; gynecological malignancy
Case Report of International Journal of Case Reports Successful experiments with Salvia officinalis and Salvia microphylla and COVID19 Florent Pirot Independent researcher This paper presents results of the author on Salvia officinalis and Salvia microphylla and COVID19. The results were achieved with dried Salvia officinalis leaves and with fresh Salvia microphylla leaves. The properties of fresh leaves appear with the taste as being much richer in antiviral agents, drying reduces the antiviral activity. The experiments presented in this paper are on the author himself, do not involve biosampling to confirm in laboratory but existing data in the published literature confirms the excellent efficiency of Salvia officinalis against COVID19 and a large array of other diseases. The self-experiments were very successful against COVID19, opening a path for natural treatment. Keywords: Novel Coronavirus 19; nCoV19; COVID19; Salvia officinalis; Salvia microphylla ...
Novel Coronavirus 19; nCoV19; COVID19; Salvia officinalis; Salvia microphylla
Epithelial-myoepithelial carcinoma of floor of mouth: A case report of double clear cell variant with immunohistochemical correlation
Case Report of International Journal of Case Reports Epithelial-myoepithelial carcinoma of floor of mouth: A case report of double clear cell variant with immunohistochemical correlation Mohamed.H.Ibrahim1, Hossam Abdel Halim2, Ihab S. Abd Elhamid3, Marwa M. Elshafei4 Shaimaa E. Ghazy5, Nermeen S. Afifi6, Ismail M. Shebl7 1Master’s degree in Oral and Maxillofacial Surgery, Faculty of Dentistry, Cairo University, 2Master’s Degree Oral and maxillofacial surgery, Cairo University, Egypt, 3Professor of Oral Pathology, Faculty of Dentistry, Badr University, Cairo, Egypt, 4Professor of Oral pathology, Faculty of Oral and Dental Medicine, Misr International University, 5Lecturer of Oral Pathology, Oral Pathology Department, Faculty of Dentistry, Ain Shams University and Misr International University, Cairo, Egypt, 6Lecturer of Oral Pathology, Oral Pathology Department, Faculty of Dentistry, Ain Shams University and Misr International University, Cairo, Egypt, 7Lecturer of Oral Pathology, Faculty of Oral and Dental Medicine, Misr International University Epithelial-myoepithelial carcinoma (EMC) is a rare biphasic low-grade malignancy accounting for only 0.5% of all salivary gland tumors. Commonly, EMC affects parotid gland (70%) and rarely affecting other ...
epithelial-myoepithelial carcinoma, double clear cell, S-100, SMA, EMA, CK-19
Case Report of International Journal of Case Reports Hormone Receptor Expression in Non Cancer Breast Lesions Arcot Rekha, Vimal Chander, Arihanth Ravichandran, Chitra S Saveetha medical College, Saveetha Institute of Medical and Technical Sciences, Thandalam. Background Estrogen receptors (ER), Progesterone receptors (PR) expression is seen in non cancer breast lesions like juvenile fibroadenomas and phyllodes tumor. Materials and Methods This is a prospective study on a study population that comprised fibroadenomas and phyllodes tumor. Results While a few studies indicate that ER/PR expression correlates with a more benign outcome ,we did not see the same in our population. Ki 67 proliferation was greater in the stromal component of phyllodes tumours,compared to fibroadenomas. Keywords: Fibroadenoma; Phyllodes tumour; Estrogen; Progesterone receptors; Ki67 ...
Fibroadenoma; Phyllodes tumour; Estrogen; Progesterone receptors; Ki67
Pseudo-endocarditis secondary to ruptured posteromedial papillary muscle with anatomical variation: A Case Report
Case Report of International Journal of Case Reports Pseudo-endocarditis secondary to ruptured posteromedial papillary muscle with anatomical variation: A Case Report Natassja Moriarty, MBBS1*; Jonathan Moriarty, MBBS2; Nadeem Attar,MBBS3; Adrian Brodison, MB chB4 1,2Department of Medicine, Furness General Hospital. 3,4Consultant Cardiologist, Furness General Hospital. Myocardial infarction is the leading cause of papillary muscle rupture. This complication occurs in up to 5% of cases post MI and although rare, it constitutes a cardiac emergency if left untreated. On this basis, a 59-year-old male presented with low-grade fever and atypical chest pain with raised inflammatory markers and troponin levels. He was treated for infective endocarditis after echocardiography revealed a mass on the mitral valve, which was presumed to be a mitral valve vegetation and so he completed a 6-weeks course of antibiotics followed by elective mitral valve replacement surgery. During surgery, it was discovered that there was no endocarditis. Instead an unusually small muscle head of one of the posteromedial papillary muscle groups had ruptured secondary to an inferior myocardial infarction ...
Papillary muscle, rupture, endocarditis, mitral valve
Secondary hyperparathyroidism and symptomatic hypercalcemia: overlooked complications of chronic liver disease
Case Report of International Journal of Case Reports Secondary hyperparathyroidism and symptomatic hypercalcemia: overlooked complications of chronic liver disease Hoilat JN1*, Hoilat GJ2, Kadan S3, Emanuele MA1 1Loyola University Medical Center, 2SUNY upstate medical center, 3Alfaisal University college of medicine A 71-year-old female with biopsy-proven liver cirrhosis was brought to the ER due to confusion for 5 days. She was diagnosed with acute decompensated liver disease and hepatic encephalopathy. Investigations also revealed PTH-dependent hypercalcemia. Both of these entities could be causing her symptoms. Neck ultrasound did not reveal any parathyroid lesions. Alteration in mental status persisted even after the management and resolution of hepatic encephalopathy. Symptomatic resolution occurred after normalization of her calcium levels which required normal saline, cinacalcet as well as calcitonin over the course of 7 days. Hypercalcemia secondary to chronic liver disease should be considered in the differential diagnosis of patients with liver cirrhosis presenting with an altered mental status. Hypercalcemia of chronic liver disease is not always transient and managed with normal saline as previously ...
Chronic liver disease; Case report