Guillain–Barré Variant as primary presentation of systemic lupus erythematosus and class V lupus nephritis


Guillain–Barré Variant as primary presentation of systemic lupus erythematosus and class V lupus nephritis


Saifat Ullah khan1, MD. Muftah Othman, MD, FRCP. Zeeshan Nasir, MBBS. Syed Hidayat Ali, MBBS. Shahid Fazal, MBBS. Saeed Takish MBChB MSc, MRCP.

1.Nephology Unit, Hazm mebaireek hospital,Qatar;  2.Hamad Medical Corporation, Doha, Qatar


Any organ of the body can be affected in systemic lupus erythematosus (SLE) which is an auto immune. Patients can present with clinical features of mild joint and skin involvement to life-threatening kidney, hematologic, or central nervous system involvement. Peripheral neuropathies in SLE is not an uncommon presentation but Guillain–Barré syndrome (GBS) is considered as an unusual and one of the least neuropsychiatric syndromes in SLE. In this case report we are aiming to report a rare association of GBS as an initial presentation for an SLE in a male patient. A 46-year-old male patient present with overlapping symptoms and required admission to intensive care unit. He was diagnosed initially as case of GBS treated with Intravenous immunoglobulin (IVIG) for five days with improvement. Patient developed overlapping symptoms of fever, palindromic polyarthralgia with active urine sediment, and proteinuria lead to diagnosis of class V lupus nephritis. Prednisolone and Mycophenolate mofetil given and he received rituximab injection for extra renal manifestation of SLE.


Keywords: Guillain–Barré syndrome (GBS), systemic lupus erythematosus, Lupus nephritis, Intravenous immunoglobulin (IVIG) Acute Inflammatory Demyelinating Polyradiculoneuropathy.

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Saifat Ullah khan, Muftah Othman, Zeeshan Nasir, Syed Hidayat Ali, Shahid Fazal,Saeed Takish. Guillain–Barré Variant as primary presentation of systemic lupus erythematosus and class V lupus nephritis. International Journal of Case Reports, 2023, 7:289. DOI: 10.28933/ijcr-2023-02-2205skan


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