Research Article of International Journal of Dental Research and Reviews
ANTICANDIDA ACTIVITY OF ETHANOL EXTRACT JERINGAU (Acorus calamus L) RHIZOME AGAINST Candida albicans ISOLATE REMOVABLE FULL DENTURE ACRYLIC
Felisha Febriane Balafif, Warta Dewi, Indrati
Department of Oral Biology, Faculty of Dentistry, Universitas Padjadjaran, Indonesia
Background: Maintaining denture hygiene by brushing and soaking it in disinfectant can prevent Candida infections. Jeringau (Acorus calamus L) is an herbal plant that its rhizome extract has antifungal activity against Candida albicans.
Aim of study: This study aimed to measure whether the value of minimum inhibitory concentration (MIC50) of ethanol extract rhizome of Jeringau against C.albicans isolates the maxillary removable full denture acrylic.
Materials and methods: Rhizome of jeringau was prepared. In vitro, study was conducted laboratory experimentally with ten samples tested by serial dilution ethanol extract rhizome of jeringau method with eight different concentrations. They were dropped to 0,1 ml C. albicans and incubated at 37 oC for 24 hours and repeated twice. They were grown on Sabouraud Dextro Agar medium that were incubated and seen its growth.
Results: Inhibition zone extract of rhizome jeringau concentration 100% on plate I (9,4 mm) and plate II (8,85 mm). MIC50 of ethanol extract rhizome of jeringau is 2,5 mg/ml.
Conclusion: Rhizome of jeringau containing β-asarone which is the major active component of antifungal against C. albicans. It was terpenoid group. Terpenoid caused porin damage. When porin was broken it would reduce the permeability of fungal cell wall resulting in fungal cells would lack of nutrients, thus the growth of fungi was inhibited
Keywords: Candida albicans, ethanol extract, Jeringau
How to cite this article:
Felisha Febriane Balafif, Warta Dewi, Indrati. ANTICANDIDA ACTIVITY OF ETHANOL EXTRACT JERINGAU (Acorus calamus L) RHIZOME AGAINST Candida albicans ISOLATE REMOVABLE FULL DENTURE ACRYLIC . International Journal of Dental Research and Reviews, 2019, 2:24. DOI:10.28933/ijdrr-2019-07-2205
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