Intracanal Cryotherapy and its Effects on the Postoperative Pain in Root Canal Therapy: Systematic Review & Meta-analysis Protocol


Intracanal Cryotherapy and its Effects on the Postoperative Pain in Root Canal Therapy: Systematic Review & Meta-analysis Protocol


Durre Sadaf1 , Muhammad Zubair Ahmad2, Igho Onakpoya3

1Assistant Professor, Department of Conservative Sciences, Qassim University, Buraidah, KSA; Evidence-Based Healthcare, Centre of Evidence-Based Medicine, University of Oxford, UK. 2Assistant Professor, Department of Conservative Sciences, Al Rass, Qassim University, KSA; Evidence-Based Healthcare, Centre of Evidence-Based Medicine, University of Oxford, UK. 3University of Oxford, Centre for Evidence-Based Medicine, Nuffield Department of Primary Care Health Sciences, Woodstock Road, Oxford OX2 6GG


American Journal of Geographical Research and Reviews

Background:  There are many research studies directing in lowering postoperative pain in root canal therapy. The use of intracanal cryotherapy in root canal treatment is recently introduced, and many researchers are inclined towards this techniques.  This systematic review will give an insight into its application in endodontic therapy and its effects on postoperative pain. The aim of this systematic review is to evaluate the effect of intracanal cryotherapy  on the postoperative pain in patients with pulp diseases and with or without peri-radicular infection during root canal therapy. This systematic review will include randomized controlled trials only. The studies should encompass patients with pulpal diseases, i.e. irreversible pulpitis and pulp necrosis in teeth. Previously root treated teeth, immature, and teeth with root resorption will not be included.

Methods: We will conduct a comprehensive search strategy using electronic databases PubMed, EMBASE (Ovid),  Scopus, and Cochrane library. A predefined inclusion and exclusion criteria will be utilized for the selection of studies. The reference list of selected studies will be manually searched. We will extract data from studies on a structured data collection form.  At the same time, the risk of bias assessment of studies using the Cochrane risk of bias assessment tools will be performed by two reviewers independently. Furthermore,  qualitative and quantitative data synthesis will be accomplished. The data will be presented in the form of table of summary of findings.

Discussion: This systematic review will assess the role of intracanal cryotherapy in the form of cold saline irrigation as a final irrigant during root canal therapy. The quality of evidence will ranked as high, moderate low or very low using GRADE approach. Comprehensive search strategy, risk of bias assessment using Cochrane risk of bias assessment tool by two reviewers are the  strength of this systematic review.

Systematic review registration number: The protocol is registered with the International Prospective Register of Systematic Reviews. (PROSPERO CRD  42020163438)


Keywords: canal irrigation; cryotherapy; irreversible pulpitis; postoperative pain; root canal therapy.

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How to cite this article:
Durre Sadaf1 , Muhammad Zubair Ahmad2, Igho Onakpoya3. Intracanal Cryotherapy and its Effects on the Postoperative Pain in Root Canal Therapy: Systematic Review & Meta-analysis Protocol. International Journal of Dental Research and Reviews, 2020, 3:35.


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