Oral Carcinoma of Squamous Cells (OCSC) and Neoplasm Recurrence: Case Report


ORAL CARCINOMA OF SQUAMOUS CELLS (OCSC) AND NEOPLASM RECURRENCE: CASE REPORT


*Mayara Larissa Moura de Souza¹, Juliana Cavalcante de Oliveira¹, Maria Gabriela Cavalcanti de Araújo¹, José Brasiliense Holanda Cavalcanti Filho2, Edvaldo Cassimiro Lins Filho2, Riana Aurea Araújo de Barros3, Aurora Karla de Lacerda Vidal 4

1Residency in Hospital Dentistry with a focus on Oncology from the University of Pernambuco – ICB / HUOC / UPE; ² Head and Neck Surgeon of the Oncology Center of the Oswaldo Cruz University Hospital of the University of Pernambuco – CEON / HUOC / UPE; 3 Medic Oncologic Clinic of the Oncology Center of the Oswaldo Cruz University Hospital of the University of Pernambuco – CEON / HUOC / UPE; 4 Profa. Dra. Adjunct of the General Pathological Processes Discipline of the Institute of Biological Sciences of the University of Pernambuco – ICB / UPE. Head of the Dentistry Department of the Oncology Center of the Oswaldo Cruz University Hospital of the University of Pernambuco – CEON / HUOC / UPE, Coordinator of the Residency Program in Hospital Dentistry with focus on Oncology at the University of Pernambuco – ICB / HUOC / UPE.


American Journal of Geographical Research and Reviews

Introduction: 95% of oral cancers are squamous cell carcinomas (SCC). Despite all advances in diagnosis and therapy, oral cavity cancer continues with an unfavorable prognosis, high rates of relapse and mortality.

Case report: Patient AFL, 69 years old, caucasian, male gender, alcoholic, smoker, diabetic, with a history of ulcerated lesion on the floor of the mouth without painful symptoms was referred to the Head and Neck Surgery Service of the Oncology Center of the Hospital University of Pernambuco – CEON / HUOC / UPE, where he was diagnosed with squamous cell carcinoma moderately differentiated, ulcerated with perineural infiltration, angiolymphatic and in bone tissue, as well as lymph node metastasis. Staging IVa (T4a N1 Mx). Multimodal therapy (surgery, radiotherapy and chemotherapy with cisplatin) was performed. Dental monitoring was maintained in pre, trans and after treatment in order to carry out the previous oral adequacy and control of oral complications due to antineoplastic therapy. After 2 years and 11 months of treatment, the patient returned to the dental clinic of the CEON / HUOC / UPE, complaining of intense pain in the oral cavity, clinically verified: ulcerated lesion with areas of reddish and whitish color, base hardened to palpation in the buccal floor region. After exams, a local recurrence of the carcinoma was diagnosed, and a new therapeutic course was planned, and salvage surgery was chosen.

Conclusion: Early diagnosis of oral ECC and medical and dental monitoring are factors that help reduce morbidity and mortality and improve the patient’s quality of life.


Keywords: Mouth Neoplasms, Carcinoma, Squamous Cell, Neoplasm Recurrence, Local, Public Health.

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How to cite this article:
Mayara Larissa Moura de Souza, Juliana Cavalcante de Oliveira, Maria Gabriela Cavalcanti de Araújo, José Brasiliense Holanda Cavalcanti Filho, Edvaldo Cassimiro Lins Filho, Riana Aurea Araújo de Barros, Aurora Karla de Lacerda Vidal. DANIEL and A.O. ADELEYE. ORAL CARCINOMA OF SQUAMOUS CELLS (OCSC) AND NEOPLASM RECURRENCE: CASE REPORT. International Journal of Dental Research and Reviews, 2020, 3:38. DOI: 10.28933/ijdrr-2020-05-1305


References:

1. Furness S, Glenny AM, Worthington HV, Pavitt S, Oliver R, Clarkson JE et al. Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy. Cochrane Database of Systematic Reviews 2011, 4. Art. No.: CD006386. DOI: 10.1002/14651858.CD006386.pub3.
2. Ministério da Saúde; Secretária de Assistência à Saúde, Instituto Nacional de Câncer; Coordenação de Prevenção e Vigilância. Estimativa 2018: incidência de câncer no Brasil. Rio de Janeiro: INCA; 2018
3. Montoro JRMC, Hicz HA, de Souza L, Livingstone D, Melo DH, Tiveron RC et al. Fatores prognósticos no carcinoma espinocelular de cavidade oral Brazilian Journal of Otorhinolaryngology, 2008 nov-dec; 74(6): 861-866
4. Chan KKW, Glenny AM, Weldon JC, Furness S, Worthington HV, Wakeford H. Interventions for the treatment of oral and oropharyngeal cancers: targeted therapy and immunotherapy. Cochrane Database of Systematic Reviews 2015, 12. Art. No.: CD010341. DOI: 10.1002/14651858.CD010341.pub2.
5. Adnan Ali SM, Awan MS, Atif S, Ali N, Mirza Y. Correlation of human papillomavirus infection and clinical parameters with five-year survival in oral squamous cell carcinoma. J Laryngol Otol 2018;1–8. https://doi.org/10.1017/S0022215118000361
6. Shah J. Cervical lymph node metastasis, its diagnostic, therapeutic and prognostic implications. Oncology 1990;4:61
7. American Cancer Society. Cancer Facts & Figures 2018. Atlanta: American Cancer Society; 2018.
8. Hyojin k, Jeong MY, Soon-hyu A, Woo-jin J, Jin-haeng C, Jin H P. Potential Oncogenic Role and Prognostic Implication of MicroRNA-155-5p in Oral Squamous Cell Carcinoma. ANTICANCER RESEARCH, 2018, 38: 5193-5200, doi:10.21873/anticanres.12842
9. Leeman CRs, BraakhuisBJM, Brakenhoff RH. The molecular biology of head and neck câncer. NATuRE REVIEwS | CanCer. 2011, Jan, 11. doi:10.1038/nrc2982
10. Vidal, AKL e Ximenes, LM. Câncer de Boca. In: Queiroz Marques, CLT; Barreto, CL; Morais VLL, Lima Júnior, NF. Oncologia uma abordagem multidisciplinar. Recife. Ed Carpe Diem, 2015; 291-309.
11. Lacerda Vidal, AK; Andrade, ESS; Macêdo, TS; Melo,MCF; Matos, FCM; Melo Júnior, BC; Silva Neto, SV. Mouth Cancer Control Program in the State of Pernambuco , Brazil. Oral Cancer. 2018 https://doi.org/10.1007/s41548-018-0014-z
12. Vidal, AKL. Protocolo Operacional Padrão de Cuidados Buco-Dentais (POP- Oral) para indivíduos sob terapia antineoplásica. Adaptado das Rotinas Internas do INCA (serviço de Odontologia), 2009. Nota Prévia (Original), 2012.
13. Hasegawa T, Otsuru M, Okura M, Yamada S, Umeda M, Kurita H et al. Multi-center retrospective study of the prognosis and treatment outcomes of Japanese oral squamous cell carcinoma patients with single lymph node etastasis and extra nodal extension. J Surg Oncol. 2018;1–8. DOI: 10.1002/jso.25083
14. Bernier J, Cooper JS, Pajak TF, Glabbeke MV, Bourhis J, Forastiere A et al. DEFINING RISK LEVELS IN LOCALLY ADVANCED HEAD AND NECK CANCERS: A COMPARATIVE ANALYSIS OF CONCURRENT POSTOPERATIVE RADIATION PLUS CHEMOTHERAPY TRIALS OF THE EORTC (#22931) AND RTOG (#9501). Risk Levels in Locally Advanced Head and Neck Cancers HEAD & NECK. 2005 Oct, DOI: 10.1002/hed.20279
15. Herchenhorn D. Estudo da fase I/II de Erlotinib (OZI-774) combinado com radioterapia e cisplatina em pacientes com carcinoma epidermóide de cabeça e pescoço, localmente avançado. São Paulo: Faculdade de Medicina da Universidade de São Paulo; 2009
16. Santos CC, Noro-Filho GA, Caputo BV, Souza RC, Andrade DMR, Giovani EM. Condutas práticas e efetivas recomendadas ao cirurgião dentista no tratamento pré, trans e pós do câncer bucal. J Health Sci Inst. 2013;31(4):368-72
17. Quispe RA, Cremonesi AL, Gonçalves JK, Rubira CMF, Santos PSS. Estudo caso-controle de índices de doenças bucais em indivíduos com câncer de cabeça e pescoço após terapia antineoplásica. einstein (São Paulo). 2018;16(3):eAO4245. https://doi.org/10.1590/S1679-45082018AO4245
18. ROSALES ACMN, ESTEVES SCB, JORGE J, ALMEIDA OP, LOPES MA. Dental Needs in Brazilian Patients Subjected to Head and Neck Radiotherapy. Braz Dent J . 2009; 20(1)
19. BONAN PRF, LOPES MA, PIRES FR, ALMEIDA OP. Dental Management of Low Socioeconomic Level Patients Before Radiotherapy of the Head and Neck with Special Emphasis on the Prevention of Osteoradionecrosis. Braz Dent J . 2006; 17(4): 336-342
20. Kernohan MD, Clark JR, Gao K, Ebrahimi A, Milross CG. Predicting the Prognosis of Oral Squamous Cell Carcinoma After First Recurrence. ARCH OTOLARYNGOL HEAD NECK SURG. 2010 Dec; 136 (12)
21. DUNN M, MORGAN MB, BEER TW. Perineural Invasion: Identification, Significance, and a Standardized Definition. DERMATOLOGIC SURGERY. 2009 Feb; 35:214–221 _ DOI: 10.1111/j.1524-4725.2008.34412.x
22. d’Alessandro AF, Pinto FR, Lin CS, Kulcsar MA, Cernea CR, Brandão LG, et al. Oral cavity squamous cell carcinoma: factors related to occult lymph node metastasis. Braz J Otorhinolaryngol. 2015;81:248-54. DOI: http://dx.doi.org/10.1016/j.bjorl.2015.03.004
23. Tam S, Araslanova R, Low TH, AndrewWarner, Yoo J, Fung K, et al. Estimating Survival After Salvage Surgery for Recurrent Oral Cavity Cancer. Otolaryngol Head Neck Surg. doi:10.1001/jamaoto.2017.0001
24. Agra IM, Carvalho AL, Kowalski LP, do Campos OD, Martins EP, Magrin J et al. Prognostic factores in salvage surgery for recurrent oral and oropharyngeal câncer. Head Neck 2006, 28:107-13
25. Zafereo M. Surgical Salvage of Recurrent Cancer of the Head and Neck. Curr Oncol Rep (2014) 16:386. DOI 10.1007/s11912-014-0386-0