International Journal of Biomedical Engineering Research

Evaluation of lectin extracted from Canavalia brasiliensis on the neuropsychomotor system of murine

Research article of International Journal of Biomedical Engineering Research Evaluation of lectin extracted from Canavalia brasiliensis on the neuropsychomotor system of murine Gonçalves, A.L.N1, Souza, A.V.F2, Borges, B.Q.O.V3, Paiva, J.C.G4, Morais, L.A5, Souza, M.B.R6 1Estudante do Curso de Medicina – UNICAP; 2,3,4,5Estudante do Curso de Medicina – UNICAP; 6Docente do Curso de Medicina – UNICAP Introduction: Lectins are a class of proteins extracted from the seeds of Canavalia brasiliensis (Lectin ConBr). Its anti-neoplastic activity has been studied in experimental models. Aim: To evaluate the neuropsychomotor effect of Lectin ConBr in vivo in murine. Methods: Thirty Swiss mice were divided into three groups: GCcontrol (n = 10) administered saline solution; G1experimental (n = 10) 50mg/kg and G2experimental (n = 10) 300mg/kg of Lectin ConBr. The neuropsychomotor analysis was performed by The Open Field Test, 4 and 24 hours after treatment. The statistic was performed by Student’s t-test. Results and Discussion: In the CG, the results obtained after 4h were: ambulation 55.4 ± 16.8; self-cleaning 4.8 ± 1.3; lifting 21.5 ± 3.41 and defecation 0.6 ± 0.5. G1: ambulation 43.4 ± 29.11; self-cleaning 3.4 ± 1.6; lifting 8.0 ± 8.1 and defecation 0.2 ± 0.44. G2: ambulation 63.0 ± 14.58; self-cleaning 1.0 ± 0.7; lifting 12.8 ± 3.1 and defecation 0.2 ± 0.44. The results obtained after 24 hours were: GC: ambulation 62.2 ± 27.9; self-cleaning 2.6 ± 1.5; lifting 15.3 ± 5.8 and defecation 1.4 ± 0.5. G1: ambulation 32.0 ± 15.7; self-cleaning 1.8 ± 1.7; lifting 6.0 ± 6.0; defecation 0.6 ± 0.5. G2: ambulation 62.0 ± 30.1; self-cleaning 0.6 ± 0.5; lifting 16.8 ± 7.3 and defecation 0.4 ± 0.5*. ConBr did not alter the spontaneous movement of the mice after 4 hours, however, the self-cleaning act and the total number of lifting in the treated groups decreased. After 24 ...

Cervical cancer: applications of genotyping for the screening in human papilomavirus (HPV)

Research article of International Journal of Biomedical Engineering Research Cervical cancer: applications of genotyping for the screening in human papilomavirus (HPV) Silva, V.M1; Santos, G.S2; Silva J.F.S3; Nascimento, E.R.S4; Wanderley, M.C.A5; Godone, R.L.N6 1,2,3,4Estudante do Curso de Biomedicina- UNINASSAU- Caruaru; 5,6Docente do curso de Biomedicina- UNINASSAU- Caruaru Introduction: Cervical cancer is considered a serious public health problem, especially in underdeveloped countries. The causal factor of the disease is infection of the vaginal mucosa by human papillomavirus (HPV). HPV consists of more than 130 genotypes, the genotypes of higher prevalence in histopathological diagnoses are subtypes 16 and 18. Currently diagnostic techniques such as pap smears and HPV test do not cover viral subtypes, important for identifying the presence of the high-risk genotypes in the sample, stopping the progression to cervical cancer. Genotyping consists of the secondary screening method for identification of viral subtypes, bringing promising prospects for the early diagnosis of the disease. Objective: To evaluate genotyping as an alternative for the early identification of the high risk HPV genotype as a possibility for the prevention of cervical cancer. Methodology: Electronic data platforms (MEDLINE, PubMed and Scopus) were consulted from 2012 to 2016, using the descriptors: “cervical cancer”, “HPV” and “genotyping”. Results and Discussion: With the applications of genotyping, it is possible to detect elements that indicate the presence of high-risk HPV subtypes in the positive samples in the initial screening techniques. Through the detection of the p16 and ki-67 proteins, which are expressed in the stages of the cell cycle, the decrease of these biomarkers indicates a deregulation in the cellular proliferation, indicating the oncogenic manifestation. The advancement of technologies has contributed to add improvements to screening programs and thus make them more effective in detecting women who have a greater potential for progression to cervical cancer. Conclusion: Although several techniques ...

The role of inflammatory mediators in carcinogenesis

Research article of International Journal of Biomedical Engineering Research The role of inflammatory mediators in carcinogenesis Silva M.R.P.1; Marcelino Neto P.P.2; Soares C.L.R.2; Lucena C.C.O.3; Correia J.C.A.1; Silva T.G.4 1Undergraduate student of the Biological Sciences Course of the Federal University of Pernambuco-UFPE; 2Graduate Student in Biological Sciences, Federal University of Pernambuco- UFPE; 3Graduate student in Pharmaceutical Sciences, Federal University of Pernambuco - UFPE; 4Professor/ Researcher of the Department of Antibiotics of the Federal University of Pernambuco- UFPE. Introduction: The process of carcinogenesis or tumor progression occurs slowly, which may take years until the formation of a visible tumor or an accumulation of abnormal, undifferentiated progenitor cells. Inflammation is a protective response of the body triggered by noxious stimuli. Studies report that the relationship between cancer and inflammation consists of the presence of inflammatory cells and inflammatory mediators in tumor tissues and angiogenesis. The inflammatory state contributes to tumor development through mechanisms such as: induction of genomic instability, stimulation of proliferation and resistance to apoptosis and induction of tumor angiogenesis. Objective: Introduce the most recent on the subject in the academic debate. Methodology: A bibliographical survey was carried out of the main academic journals with articles from the last five years. Results and Discussion: Studies have shown the frequent appearance of tumors in sites of chronic inflammation, besides the presence of inflammatory cells and mediators in tumor tissues, such as chemokines, cytokines and cyclooxygenase (COX), an enzyme responsible for the formation of important mediators including prostaglandins. Chemokine receptors are primarily responsible for leukocyte migration during inflammation and carcinogenesis, directly involved in the invasion, motility and survival of tumor cells. In relation to cytokines, TNF-α (tumor necrosis factor) stimulates growth. The presence of elevated serum levels of IL-6 in cancer patients was also observed. At the enzyme level, COX-2 overexpression is associated with ...

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International Journal of Biomedical Engineering Research