International Journal of Bioscience and Medicine


EXECUTIVE FUNCION: COGNITIVE DEVELOPMENT, ADOLESCENCE AND DRUG ABUSE

Review Article of International Journal of Bioscience and Medicine EXECUTIVE FUNCTION: COGNITIVE DEVELOPMENT, ADOLESCENCE AND DRUG ABUSE Aparecido Jonanthan Mandú de Araújo¹*, Caio Matheus Santos da Silva Calado¹, Danielle Dutra Pereira¹, Juliana Marina Campelo² e Jennifer Hellen Melo Sobral². ¹ Universidade Federal de Pernambuco.² Centro Universitário Maurício de Nassau. Introduction: Neuroscience brings advances and revelations of specificities and functionalities of the nervous system, contributing to the understanding of the exposure influences of neuroanatomic structures in various physiological and behavioral factors. Given this, it is known that executive functions are modeled as the most diverse forms of social interaction and are closely linked to the prefrontal lobe. These skills are consolidated only in adulthood. In this sense, the nervous system in adolescence is subject to changes in its development for social and cultural reasons. Objective: In this sense, the aim of this study is to analyze the use and abuse of recreational drugs that act on the nervous system and their influence on executive functions and cognitive development during adolescence. Methodology: The methodology used was a literature review of the integrative type in the PUBMED and ScieELO databases published in the last 10 years. Results and discussions: The use of alcohol, marijuana and inhalants are causative agents of cognitive impairment, especially in processing speed and response and working memory during adolescence, but results are still controversial as information such as dosage is lacking. , time of use and time of abstinence of users. Final Considerations: The results showed controversies in the performance of these substances in neurobiological bases and their long term damages; Therefore, further longitudinal studies are needed to monitor the cognitive development of these diseases and cognitive impairment and its consequences in adulthood. Keywords: Neurophychology. Cognitive Desenveloped. Executive System. Drug ...

EVALUATION OF PERIODONTAL DISEASE IN RATS SUBMITTED TO THE ADMINISTRATION OF CYTHOCBACTERIA ARTHROSPIRA SP. (“SPIRULINA SP.”) AS A FUNCTIONAL SUPPLEMENT

Research Article of International Journal of Bioscience and Medicine EVALUATION OF PERIODONTAL DISEASE IN RATS SUBMITTED TO THE ADMINISTRATION OF CYTHOCBACTERIA ARTHROSPIRA SP. ("SPIRULINA SP.") AS A FUNCTIONAL SUPPLEMENT Ana Luiza Batista de Lima1, Carina Scanoni Maia2, Luciana Maria Silva de Seixas Maia3, Danielli Matias de Macêdo Dantas4, José de Castro Neto Júnior5,Juliana Pinto de Medeiros*6 1,2,3,6Universidade Federal de Pernambuco, Departamento de Histologia e Embriologia. 4Unidade Acadêmica de Serra Talhada da UFRPE, 5Universidade Federal do Rio Grande do Norte. Objective: To evaluate the therapeutic effect of cyanobacteria Arthrospira sp. in the evolution of periodontal disease. Methods: Eight rats, aged 90 days weighing 280 ± 300g, were used from the Animal Experimentation Center Animal Hospital of the Department of Pharmaceutical Sciences of the Federal University of Pernambuco. After an adaptation period of 10 days, the animals were randomly divided into three groups, namely: Group I - Control Rats, without administration of cyanobacteria; Group II - Rats with periodontal disease without administration of cyanobacteria; Group III - Rats with periodontal disease with cyanobacteria administration. All animals were induced to periodontitis, which was made by ligature with cotton thread, and this wire was placed around the gingival sulcus of the left upper first molar, with this application there was accumulation of residues, causing the formation of dental biofilm. Results: After the morphological analysis of the experimental groups, we observed that there was a significant effect among the studied groups, where the periodontal ligament was preserved (treated group) or showed absence of tissue integrity (untreated group). Conclusion: The administration of Arthrospira sp. in rats with periodontal disease, suggests to be an important ally in the fight against the progression of periodontitis, thus acting in the control of this disease. Keywords:periodontal disease, rats, spirulina, functional supplement ...

Phytochemical profile and cytotoxic activitys of Zanthoxylum tingoassuiba A. St. Hil extract

Research Article of International Journal of Bioscience and Medicine Phytochemical profile and cytotoxic activitys of Zanthoxylum tingoassuiba A. St. Hil extract Francisco Henrique da Silva1 *, Amanda Virgínia Barbosa1, João Ricardhis Saturnino de Oliveira1, Matheus Alves Siqueira de Assunção2, Fálba Bernadete Ramos dos Anjos2, Márcia Vanusa da Silva1 1Biochemistry Department, Federal University of Pernambuco, Recife, Pernambuco, Brazil. 2Department of Histology and Embryology, Federal University of Pernambuco, Recife, Pernambuco, Brazil The Caatinga phytogeographic domain represents 11 % of the Brazilian territory and presents a plant singularity that is not described anywhere else in the world. From this perspective, this study aimed to evaluate the phytochemical and cytotoxic profile of the aqueous extract of the plant species Zanthoxylum tingoassuiba A. ST. Hil, in addition to the evaluation of the photoprotective activity. The methodology used for these analyzes consisted of the collection and determination of secondary compounds of the species, by thin layer chromatography, in addition to the evaluation of the cytotoxic activity by different methods, as well as the evaluation of the photoprotective activity by spectrometry. As a result, it was noticed that the extract did not present erythrocyte hemolysis, as well as cytotoxicity by MTT in relation to the controls. Keywords: Caatinga; Cytotoxic; Evaluation ...

Evaluation of the antioxidant activity of extracts obtained from the seaweed Caulerpa taxifolia

Research Article of International Journal of Bioscience and Medicine Evaluation of the antioxidant activity of extracts obtained from the seaweed Caulerpa taxifolia Evandro Valentim da Silva1*, Romário Correia dos Santos2, Jose Ferreira Silva Neto3, George Chaves Jimenez4, Ivone Antônia de Souza5; Fálba Bernadete Ramos dos Anjos6 1Programa de Pós-Graduação em Ciências Farmacêuticas da Universidade Federal de Pernambuco UFPE; 2Graduando do Curso de Odontologia da Universidade Federal de Pernambuco - UFPE. 3Programa de Pós-Graduação em Química Fundamental da Universidade Federal de Pernambuco UFPE; 4Professor de Fisiologia Animal da Universidade Federal Rural de Pernambuco- UFRPE; 5Professora do Programa de Pós-Graduação em Ciências Farmacêuticas da Universidade Federal de Pernambuco – UFPE; 6Professora do Departamento de Histologia e Embriologia - UFPE This study aimed to evaluate the antioxidant activity of the extracts of marine seaweed Caulerpa taxifolia by two methods of study of antioxidant activity. The antioxidant activity of the extracts hidroalcolico, methanol and hidroalcolico was evaluated according to Mitsuda (1967). The ability of the extracts to kidnap hydrogen peroxide was determined by Ruch method (1989). The analysis carried out by reading the samples in octoplicata in spectrophotometer, it was possible to calculate the antioxidant and scavenging activities of the extracts hydrogen peroxide. The antioxidant activity presented by the three extracts from C. taxifolia by the ferric thiocyanate method varied each other, showing the methanol extract greater activity than the alcohol and aqueous extracts hydro, may be due to the presence of secondary metabolites like terpenoids. The kidnapper power of hydrogen peroxide of Caulerpa taxifolia strata known significant values when compared to the reference drug. Keywords:Green algae, Ferric thiocyanate, Hydrogen peroxide ...

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International Journal of Bioscience and Medicine

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