International Journal of Bioscience and Medicine


Thaumatococcus daniellii Benn. (Marantaceae) Leaf Methanol Extract Possessed Hepatoprotective Effect Against Acetaminophen-induced Liver Injury in Albino Rats

Research Article of International Journal of Bioscience and Medicine Thaumatococcus daniellii Benn. (Marantaceae)  Leaf Methanol Extract Possessed Hepatoprotective Effect Against Acetaminophen-induced Liver Injury in Albino Rats Ukwubile CA, 2Musa YD and  2Troy SM 1Department of Science Laboratory Technology, Biology Unit, School of Science and Technology, Federal Polytechnic Bali, Nigeria. 2Department of Pharmacognosy, Faculty of Pharmacy, University of Maiduguri, Nigeria. [Background]Acetaminophen or Paracetamol is widely used as analgesic and antipyretic or antimalarial drug, but at high dose it leads to undesirable side effects, such as hepatotoxicity. [Objective]This present study demonstrates the in vivo hepatoprotective effect of Thaumatococcus daniellii against acetaminophen induced liver toxicity. [Methods] Acetaminophen- induced liver injury was evaluated by an increase in serum AST (or SGOT), ALT (or SGPT), ALP activity and bilirubin level accompanied by significant decrease in albumin level. [Results] Acetaminophen hepatoxicity was manifested by an increase in lipid peroxidation, depletion of reduced glutathione (GSH) and catalase activity in liver tissue. Oral administration of the plant extract protects the rats against acetaminophen induced liver injury by increased lipid peroxidation, restored altered serum marker enzymes and antioxidant level to normal liver morphology.[Conclusion]The results showed that T. daniellii leaf extract displayed significant liver healing efficacy against acetaminophen induced hepatotoxicity in rats. The result further affirm the use of the plant as an ethno-medicinal prescription for liver related injury. Keywords: Acetaminophen, hepatoprotective, Thaumatococcus daniellii, liver injury. Abbreviations Used: ALT = Alanine aminotransaminase or serum glutamic pyruvic transaminase, AST = Aspartate aminotransaminase or serum glutamic oxaloacetic transaminase, ALP = alkaline phosphatase ...

Soluble fibrin as a biomarker for intrahepatic microthrombosis in acute-on-chronic liver failure

Research Article of International Journal of Bioscience and Medicine Value of soluble fibrin as a biomarker for intrahepatic microthrombosis and its sequel acute-on-chronic liver failure in chronic hepatitis C patients Ehab F. Mostafa, Waleed A. Ismail, Amr Elhwary1, Ayman M. Marei 2. 1. Internal medicine department, Hepatology divison, Zagazig University. 2. Microbiology department, Zagazig University. Background: There is a lack in finding the precipitating factor in acute –on chronic liver failure (ACLF)insult in large number of patients and either this factor is hepatic or extra hepatic origin. Aim of the work : Our study aiming to evaluate the potential usefulness of a new plasma soluble fibirin polymer (SF) assay for diagnosing the possibility of occurrence of intrahepatic microthrombosis as a cause of ACLF in patients with chronic hepatitis C virus. Patients & Methods: The study was carried out in Zagazig University Hospital, internal medicine department in collaboration with microbiology department from February 2015 tell November 2015. 50 patients having chronic hepatitis c virus was enrolled in this study with ACLF developing new onset ascitis in 15 patient encephalopathy in 12 patients, jaundice in12 and elevated INR in 11 patients all having regular follow-up in hepatology clinic in Zagazig university Hospital with stable clinical course in the previous three months. Control subject was classified as normal subject 20 and 30 patients with compensated chronic hepatitis C virus infection. All patients and control groups were subjected to full history, complete clinical examination and laboratory tests including CBC, INR, serum albumin, serum bilirubin, liver enzymes, ascitic fluid examination and culture, blood culture, alpha-fetoprotein, d D-dimer, thrombin generation and soluble fibrin polymer., abdominal ultrasound, Doppler ultrasound for portal vein. Results: Our results showed significant difference between patients group and both  control groups regarding SF and D-dimer, also there were significant differences in patients group ...

Optimization of fermentation conditions for the production of 2,3-butanediol by Klebsiella pneumonia ZH-1 using response surface methodology

Research Article of International Journal of Bioscience and Medicine Optimization of fermentation conditions for the production of 2,3-butanediol by Klebsiella pneumonia ZH-1 using response surface methodology LI Li, Feng HE, Jian-Guo XU and Qing-Ping HU * College of Life Science, Shanxi Normal University, Linfen, Shanxi 041000, China [Background] It has been studied that the yield of 2,3-butanediol (2,3-BD) producing strains is low and does not meet the requirements of industrial production of 2,3-BD. [Objective] It was important to improve the production of 2,3-BD by Klebsiella pneumonia ZH-1 in shaking flask. [Methods] The effects of temperature, pH and rotating speed on the production of 2,3-BD were studied by single factor test and response surface method. [Results] The optimal cultivation conditions stimulating the maximal production of 2,3-BD were as follow: initial pH, 7, temperature, 37 oC and rotating speed, 140 r/min. Under this optimized conditions, the predicted maximal 2,3-BD yield was 21.54 g/L, whereas the yield of 2,3-BD can reach to 22.04 g/L after the application of response surface methodology. [Conclusion] Response surface methodology was a promising method for optimization of 2,3-BD production. Keywords: K. pneumonia ZH-1, response surface methodology, 2,3-butanediol ...

Prevalence and Associated Factors of Antiepileptic Drugnonadherence Among Epileptic Patients Attending at Out Patient Departement of Dilla University Referral Hospital, Dilla,gedeo,snnpr, Southern Ethiopia

Research Article of International Journal of Bioscience and Medicine Prevalence and Associated Factors of Antiepileptic Drugnonadherence Among Epileptic Patients Attending at Out Patient Departement of Dilla University Referral Hospital, Dilla,gedeo,snnpr, Southern Ethiopia Maregu Shegaw (BSC) 1, Reta kassa (BSC, MPH )2, Yigrem ali (BSC, MSc)3, Negatu Addissu (BSC, MSc)4 1Depratment of Psychiatry, college of health sciences and Medicine , Dilla University,Ethiopia. 2Depratment of public health, college of health and Medical sciences, Dilla University , Ethiopia. 3Department of psychiatry, college of health sciences and Medicine , Dilla University,Ethiopia 4 Department of Pharmacy, college of health sciences and medicine, Dilla University, Ethiopia Background: Antiepileptic drugs are effective in the treatment of epilepsy, but poor adherence to medication is major problem to sustained remission and to functional restoration. Poor adherence to treatment is one of many reasons for pharmacological treatment failure and seizure recurrence. Even though there were studies on the magnitude and associated factors of Antiepileptic drugs non-adherence, there is a shortage of published information regarding the prevalence and associated factors of Antiepileptic drugs none-adherence in Ethiopia. Objective: To assess prevalence and associated factors of antiepileptic drug none-adherence among epileptic patients attending at Dilla University Referral Hospital Methods: Institutional based cross sectional study design was conducted at Dilla University Referral Hospital from March to May, 2016. A total of 265 individuals was selected by simplerandom sampling method and interviewed by using structured questionnaire. 8 itemMorisky Medication Adherence Scalewas used to assess the prevalence of antiepileptic drug non adherence. Data was coded and exported to SPSS version 20 for analysis. Results: The prevalence of Antiepileptic’s drug none-adherence in this study was 38.1% and getting medication by payment [AOR2.009, 95%,CI:1.044, 3.868], Patients who did not got health information about(their illness, duration of treatment and drug side effect) [AOR=0.319,95%,CI:0.184,0.534],  poor social support [AOR=3.06, 95%, CI: ...

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International Journal of Bioscience and Medicine

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