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International Journal of Dental Research and Reviews

International Journal of Dental Research and Reviews, Recent Articles

Changes in mandibular CDH5, CXCL1, and PECAM1 expression following exposure to bisphosphonate and molar extraction suggest a loss of vascular endothelial cell barrier integrity plays a role in MRONJ

Research Article of International Journal of Dental Research and Reviews Changes in mandibular CDH5, CXCL1, and PECAM1 expression following exposure to bisphosphonate and molar extraction suggest a loss of vascular endothelial cell barrier integrity plays a role in MRONJ James L. Borke College of Dental Medicine, Biomedical Sciences, Western University of Health Sciences, Pomona, California, UNITED STATES Objectives: Medication related osteonecrosis of the jaw (MRONJ) is a disorder characterized by loss of blood supply to the jaws and death to the bone. In our previous work, we created a rat model of MRONJ by multiple injections of 60ug/Kg zoledronic acid (ZA) via tail vein followed by extraction of a single first molar. We have previously shown in this model a decrease in the vasculature of the jaws and a delay in bone healing after 6 weeks. The current study was designed to look at mRNA expression and immunohistochemical localization of three endothelial cell markers (CDH5, CXCL1 and PECAM1) 6 weeks following ZA injection with and without molar extraction and in saline injected rats as controls.  The objective of this study is to determine if the expression of these markers may serve to identify clinically significant changes in vascular endothelium barrier function associated with the onset of MRONJ. Methods: Using RT-PCR, we analyzed the expression of mRNA for angiogenic markers, six weeks after injection with either 60ug/Kg ZA or saline as a control and in ZA injected rats following first molar extraction.  Routine immunohistochemical procedures with antibodies specific for rat marker proteins were used to study the immunohistochemical localization of proteins translated from the mRNA angiogenic markers with significant expression. All tissues were processed together under identical conditions. Results: We found a decrease in the mRNA expression of CDH5, and PECAM1 and an increase in CXCL1 expression six weeks after extraction ...
International Journal of Dental Research and Reviews, Recent Articles

Integrating Acoustic Pharyngometry And Rhinometry In Orthodontic Practice And Training

Review Article of International Journal of Dental Research and Reviews Integrating Acoustic Pharyngometry And Rhinometry In Orthodontic Practice And Training Sanjeev Datana, Indranil Deb Roy Dept of Dental Surgery & Oral Health Sciences, Armed Forces Medical College, Pune Orthodontics and dentofacial orthopedics, the first specialty of dentistry aims for correction of malocclusion, by movement of teeth, orthopedic changes in jaw bones with growth modulation or by ortho-surgical planning for the varied skeletal malocclusion. Rapid Palatal Expansion (RPE) for treatment of maxillary constriction, growth modulation with forward posturing of lower jaw with myo-functional appliances and surgical repositioning of jaw bones with orthognathic surgery results in alteration of the nasal and oral volume. These changes affect the nasal and oral breathing patterns of the patient and may result in correction of Sleep Breathing Disorders (SBD) like Obstructive Sleep Apnoea (OSA). The conventional methods used to study these changes include 2D cephalometry, rhinomanometry etc. However, with the introduction of 3D evaluation technolo-gy of the craniofacial structures, it has helped orthodontist to evaluate these changes in volume. The contemporary methods include CT, CBCT and MRI. One less commonly explored modality in the field of Orthodontics is Acoustic Rhinometry (AR) and Acoustic Pharyngometry (AP), which is a non-invasive, non-ionizing modality to study upper airway in dynamic state. The AP device uses acoustic reflection technology to accurately map out the size, structure and collapsibility of the oral and nasal airway. The efficacy of the AP is found to be comparable with that of 2D Cephalometry and 3D modalities like CT, CBCT & MRI. This aim of this paper is to highlights the principal, use and importance of AP in the field of orthodontics and to advocate the use of this modality in ortho-dontic practice and training. Keywords: upper airway, CBCT, clinical assessment, orthodontics ...
International Journal of Dental Research and Reviews, Recent Articles

Magnitude Of Dental Anxiety And Associated Factors Among Outpatient Dental Clinics Of Ayder Comprehensive Specialized Hospital And Mekelle General Hospital

Research Article of International Journal of Dental Research and Reviews Magnitude Of Dental Anxiety And Associated Factors Among Outpatient Dental Clinics Of Ayder Comprehensive Specialized Hospital And Mekelle General Hospital, Northern Ethiopia Firaol Mesfin Ayele1*, Lidya Tadesse2 1Department of Psychiatry, Mekelle University-Collage of Health Science, Mekelle, Ethiopia.2School of Dentistry, Mekelle University-Collage of Health Science, Mekelle, Ethiopia. Background: Dental anxiety has been reported to lead to avoidance behavior and cause a delay in regular or necessary dental treatment and this also negatively affects dental health. However, the problem remained rarely investigated in our setting and at the national level. This study aims to assess the prevalence of dental anxiety and associated factors among dental clinics of Ayder comprehensive specialized hospital and Mekelle hospital. Objectives: To assess the magnitude of dental anxiety and associated factors among dental clinics of Ayder comprehensive specialized hospital and Mekelle hospital, Mekelle, Tigrai, Northern Ethiopia, 2019. Methods: An Institutional based cross-sectional study design was conducted to assess the prevalence of dental anxiety. The study was conducted from September 2019 to November 2019 on a total sample size of 236. A systematic random sampling technique was used to select participants. A Farsi version of the MDAS questionnaire was used to collect the data. The data collected was entered into a computer for analysis mainly using Statistical Package for Social Sciences (SPSS) for version 21. Then, data were coded, cleaned and some consistency checks were made to assess the quality. It was done by running frequencies and cross-tabulation among various reported cases or variables. Result: Females were 1.89 times AOR=1.896, 95% CI, [1.003-3.585] higher than males to develop dental anxiety. Urban residents were 2.57 times AOR= 2.576, 95% CI, [1.060-6.259] higher to develop dental anxiety than those who reside in rural. Regarding avoidance of dental care, those who avoid ...
International Journal of Dental Research and Reviews, Recent Articles

Ozonoterapia- An Alternative To Conventional

Review Article of International Journal of Dental Research and Reviews Ozonoterapia- An Alternative To Conventional Praisy Francis, Sidratul Muntaha, Prashnat Babaji, Shashi Bhushan K.K Sharavathi dental college The use of ozone in oral health care is flourishing with the evidence of its effectiveness in treating dental caries. As we know its importance in the troposphere is now witnessed in the dental sphere. There is growing evidence that it can be employed as a therapeutic agent in both medicine and dentistry. Its painless, atraumatic, non-invasive nature and absence of discomfort make it an ideal treatment option especially in the case of paediatric patients where patient’s acceptance is of utmost importance. So, this article summarizes the therapeutic benefits of ozone in dentistry. Keywords: Ozone, dental applications of ozone, ozone therapy, contraindications of ozone ...

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International Journal of Dental Research and Reviews

Prof. Mohamed Said Hamed
Dean & Professor – Oral & Maxillofacial Surgery, College of Dentistry, Gulf Medical University, United Arab Emirates

Dr. Amer A. Taqa
Professor, College dentistry, Mosul University

Dr. Punit Naidu
Vice Chairman, Rajarajeswari Dental College and Hospital Bangalore

Dr. Victor Eduardo de Souza Batista
Associate Professor, Department Prosthodontics, Presidente Prudente Dental School, University of Western São Paulo – UNOESTE, Presidente Prudente, São Paulo, Brazil

Dr. Faaiz Alhamdani
Assistant Prof., Head of Clinical Sciences Department, College of Dentistry, Ibn Sina University

Dr. Abbas R. Zaher
Professor of Orthodontics and Chairman, department of orthodontics, Faculty of Dentistry, the University of Alexandria; President, The Egyptian Orthodontic Society; Past Vice-President, the World Federation of Orthodontists

Dr. Ibrahim El-Sayed M. El-Hakim
Professor, Ain Shams University

Dr. Ajay Jain
Associate Professor, Faculty of Dentistry, AIMST University

Dr. RAÚL GONZÁLEZ-GARCÍA
Department of Oral and Maxillofacial-Head and Neck Surgery, University Hospital Infanta Cristina, Avenida de Elvas s/n, 06080, Badajoz (Spain)

Dr. Indrajeet Ghosh
Practice Principal/ Clinical Director of Dental Zone

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