International Journal of Hospital Pharmacy


To analyze the occurrence and profile of potential drug interactions in ICU patients at the Alcides Carneiro University Hospital

Research Article of International Journal of Hospital Pharmacy To analyze the occurrence and profile of potential drug interactions in ICU patients at the Alcides Carneiro University Hospital Brito T.A.M1; Gomes A.M.P.2; Oliveira F.S.3 1Estudante do Curso de Bacharelado em Farmácia – UFCG; 2Estudante do Curso de Bacharelado em Farmácia - UFCG, 3Docente do Centro de Educação e Saúde da UFCG. Introduction: As drug associations without treatment of chronic diseases are very common, especially in intensive care unit (ICU) patients, however, they may cause drug interactions, such as those that are responsible for therapeutic failure, life-threatening of patients and generating high costs for the hospital. Objective: This study aimed to analyze the occurrence and profile of potential drug interactions in ICU patients at the Alcides Carneiro University Hospital. Methodology: a data collection performed from January to June 2015, based on ICU prescriptions. The data were collected through a specific form for this purpose. For the Drug-Reax system of the Micromedex® Health Series software. Results: Among the 109 prescriptions evaluated, 76 (69.72%) presented some interaction, totaling 244 potential interactions. Among the 54 (49.5%) male patients, 41 (75.92%) had a MI. A median of 6.91 prescription medications was observed. All patients who used 10 or more drugs had some type of interaction. Conclusion: It was possible to evaluate an average of prescription drugs, more prescription drugs and their interactions, based on the profile of interactive pharmacological potentials of the Alcides Carneiro University Hospital. Keywords: Drug interactions; Pharmacotherapy; Chronic diseases ...

Selective Serotonin Reuptake Inhibitors Induced Serotonin Syndrome

Review Article of International Journal of Hospital Pharmacy Selective Serotonin Reuptake Inhibitors Induced Serotonin Syndrome –A Case Report Ananth kashyap*, Rashmi N G, Rakshith U R, Hanumanthachar Joshi Smriti College of Pharmaceutical Education, Indore Serotonin syndrome also known as serotonin toxicity is a potentially life threatening syndrome that is precipitated due to excess serotonin within CNS. It results in variety of mental, autonomic and neuromuscular changes which ranges in severity from mild to fatal. It is nearly always caused by drug interaction involving two or more serotonergic drugs atleast one which is SSRIs. This is a case of 35- year- old female patient, admitted to hospital with 2 episodes of seizures, fever, headache, depression and was put on sodium valproate, clonazepam+escitalopram, paracetamol, sertraline. The patient medical history reveals that she is a known case of major depression and syncopal attack and was on escitalopram oxolate from 1 year. After two days of therapy patient developed tremors, restlessness, muscle rigidity, shivering and was clonus. On examination, variation in vitals was noticed and diagnosed as serotonin syndrome by review of medication chart sertraline was stopped and lorazepam was administered and patient showed good response and felt better. Proper education and awarness about drugs, drug-drug interaction causing SS its accuracy of diagnosis that prevents morbitiy and mortality in patients prescribed with SSRIs is of utmost importance.  Keywords: Serotonin syndrome, Selective serotonin reuptake inhibitors, Drug-drug interaction ...

Assessing the strengths and weaknesses of a computer assisted medication review in hospitalized patients

Research Article of International Journal of Hospital Pharmacy Assessing the strengths and weaknesses of a computer assisted medication review in hospitalized patient Kim P.G.M. Hurkens1, Carlota Mestres-Gonzalvo2, Hugo A.J.M. de Wit2, Rob Janknegt2, Frans Verhey3, Jos M.G.A. Schols 4,6, Fabienne Magdelijns 5, Coen D.A. Stehouwer5,6, Bjorn Winkens 6, 7, Wubbo Mulder5 and P. Hugo M. van der Kuy2 1Department of Internal Medicine, section of Geriatric Medicine, Zuyderland Medical Centre, PO box 5500, Sittard-Geleen-Heerlen, the Netherlands; 2Department of Clinical Pharmacy and Toxicology, Zuyderland Medical Centre, PO box 5500, Sittard-Geleen-Heerlen, the Netherlands; 3Alzheimer Centre Limburg, School of Mental Health and Neuroscience, Maastricht University Medical Centre, PO box 5800, Maastricht, the Netherlands; 4Department of Family Medicine and Department Health Services Research, Maastricht University Medical Centre, PO box 616, 6200 MD Maastricht, the Netherlands; 5Department of Internal Medicine, Maastricht University Medical Centre, PO box 5800, Maastricht, the Netherlands; 6School for Public Health and Primary Care (CAPHRI), Maastricht University Medical Centre, PO box 616, 6200 MD Maastricht, the Netherlands; 7Department of Methodology and Statistics, Maastricht University Medical Centre, PO box 616, 6200 MD Maastricht, the Netherlands. Introduction Medication reviews are an essential part of daily routine at a hospital ward but are prone to mistakes. With this study we want to assess the strengths and weaknesses of a Clinical Decision Support System (CDSS) and evaluate the additional value on the reduction of medication errors compared with manual medication reviews. Materials and Methods We gathered all remarks related to (potential) errors in the current medication regime (notifications) regarding medication errors for 332 patients from 12 grand rounds of the internal medicine ward and orthopedic ward at the Maastricht University Medical Centre during four months. Simultaneously, we electronically extracted data regarding the patient’s medication list, laboratory data and patient characteristics and entered these data into our CDSS ...

Bioassay guided fractionation-an emerging technique influence the isolation, identification and characterization of lead phytomolecules

Review Article of International Journal of Hospital Pharmacy Bioassay guided fractionation-an emerging technique influence the isolation, identification and characterization of lead phytomolecules Neelesh Malviya*1, Sapna Malviya 2  * 1 Smriti College of Pharmaceutical Education, Indore 2 Modern Institute of Pharmaceutical Sciences (MIPS), Indore Natural products have thus played an important role in drug discovery in the past and promise to provide still more drugs in the future. The search for a new drug from nature is based on a biological and ecological rationale. Natural products have provided many effective drugs. These include older drugs such as quinine and morphine and newer drugs such as paclitaxel, camptothecin, etoposide, mevastatin, and artemisinin. The discovery of novel drugs from nature is also important because many isolated molecules are quite complex, and would not be obtained by a simple synthetic approach. Most bioactive compounds of natural origin are secondary metabolites, i.e. species-specific chemical agents that can be grouped into various categories. A typical protocol to isolate a pure chemical agent from natural origin is bioassay-guided fractionation, meaning step-by-step separation of extracted components based on differences in their physicochemical properties, and assessing the biological activity, followed by next round of separation and assaying.  Keywords: Drug discovery, Natural products, bioassay-guided fractionation ...

Manuscript Title: The title should be a brief phrase.

Author Information: List full names and affiliation of all authors, including Emails and phone numbers of corresponding author.

Abstract: The abstract should be less than 500 words. Following abstract, a list of keywords and abbreviations should be added. The keywords should be no more than 10. Abbreviation are only used for non standard and long terms.

Introduction: The introduction should included a clear statement of current problems.

Materials and Methods: This section should be clearly described.

Results and discussion: Authors may put results and discussion into a single section or show them separately.

Acknowledgement: This section includes a brief acknowledgment of people, grant details, funds

References: References should be listed in a numbered citation order at the end of the manuscript. DOIs and links to referenced articles should be added if available. Abstracts and talks for conferences or papers not yet accepted should not be cited.

Tables and figures: Tables should be used at a minimum with a short descriptive title. The preferred file formats for Figures/Graphics are GIF, TIFF, JPEG or PowerPoint.

Publication fees: We do not charge any submission charges, but authors are required to pay publication fees after their manuscripts are accepted for publication. For authors who receive our invitations, please send us the invitation code.

Proofreading and Publication: A proof will be sent to the corresponding author. Authors should carefully read it to avoid any errors and return any comments. We will update and publish it shortly. One of our goals is to minimize our publication time. For authors who do not return comments of proofreading on time, we may put the proof onlinefirst and replace it later with the final version. 

Withdrawal/retraction Policy: When you want to withdraw/retract a published article, please send us your written request by email. We will withdraw/retract it from our system after reviewing the request. Please allow us enough time to process it. 

Terms of Use/Privacy Policy/Disclaimer/Other Policies: eSciPub LLC is a publisher to support Open Access initiative located in Houston, Texas, USA. We are a member of the largest community of professional publishers in the United States: the Independent Book Publishers Association. All journals are solely owned by eSciPub LLC and have no affiliation/relationship with any other(s). You agree that by using or receiving our services, you have read, understood, and agreed to be bound by all of our terms of use/privacy policy/ disclaimer/ other policies(Click here for details).

About the journal
The journal is solely owned and hosted by eSciPub LLC and has no affiliation/relationship with any other(s). Our aim is to provide a platform that encourages publications of the most recent research/reviews for authors of all countries.


About the publisher
eSciPub LLC is a publisher to support Open Access initiative located in Houston, Texas, USA. It is a member of the largest community of professional publishers in the United States: the Independent Book Publishers Association. It hosts more than 100 Open Access journals in Medicine, Business, Economics, Agriculture, Biological Sciences, Chemistry, Education, Physical Sciences, Sociology, Engineering.


Rapid Response Team
Please feel free to contact our rapid response team if you have any questions. Our customer representative will answer your questions shortly.

International Journal of Hospital Pharmacy

Loading