International Journal of Neuroscience Research

Methyl jasmonate ameliorates memory deficits in mice exposed to passive avoidance paradigm

Research Article of International Journal of Neuroscience Research Methyl jasmonate ameliorates memory deficits in mice exposed to passive avoidance paradigm Anthony T. Eduviere1, Osarume Omorogbe2 and Solomon Umukoro2* 1Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Ibadan, Nigeria 2Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, Nigeria Passive avoidance task is a rodent model of memory in which the animal learnt to avoid an aversive stimulus precipitated by fear and it is always accompanied by inhibition of motor behavior. We have shown in our previous studies that methyl jasmonate (MJ), a bioactive compound isolated from Jasminum grandiflorum demonstrated memory enhancing effect in hippocampal-dependent memory tasks such as Y-maze and object recognition tests in mice. This present study was designed to investigate if MJ could ameliorate memory deficits associated majorly with the activation of the amygdala in response to an aversive stimulus in the passive avoidance paradigm. The present study also evaluated the effect of MJ on scopolamine (SC)- and lipopolysaccharide (LPS)-induced memory impairment in the passive avoidance paradigm. Mice were given intraperitoneal (i.p) injection of MJ (10-40 mg/kg), donepezil, DP (1 mg/kg) or vehicle daily for 7 days before testing for memory using passive avoidance step-down apparatus. In the interaction studies, the effects of SC (3 mg/kg, i.p.) or LPS (250 µg/kg, i.p.) given alone or with MJ (10, 20, 40 mg/kg) or DP (1 mg/kg) for 7 consecutive days were also evaluated. SC and LPS were injected 30 min after MJ or DP administration. The time it took (step-down latency) the mouse to step down from the elevated vibrating platform onto the grids (electrified stainless steel bars on the floor of the cage), which indicates memory function was recorded. Our findings revealed that MJ (10-40 mg/kg, i.p.) ameliorated memory deficits ...

Mental health in Bhagavad Gita

Research Article of International Journal of Neuroscience Research Mental health in Bhagavad Gita Dr B V Pattabhiram*,Director Prasanthi Guidance & Counselling Centre, Hyderabad Dr Balaji Deekshitulu P V**, Psychologist & Alternative Medicine (Homeopathy) Practitioner, Sri Balaji Clinic, Tirupati, A.P, India.cell:8885391722,7207255557 In this review article the .Bhagavad-Gita is a sermon given by Lord Sri Krishna to Arjuna in the battlefield. The three principles which have been emphasized by the Bhagavad-Gita are the management of mind, management of duty and the principles of self-management. The principles propounded therein, seem to have universal application and useful for all human beings to mould their character and strengthen themselves to develop their managerial effectiveness. Bhagavad gita are increasing in mind management and reducing mental and physical illnesses is an important stimulus of human growth and creativity as well an inevitable part of life. This paper aims at exploring the divine principles in Bhagvad Gita for its application to mind management & development of human capital. Keywords: Gita, Management therapy, mind ...

Effect of Cymbopogon citratus (Lemon Grass) on acute anoxic stress in mice

Research Article of International Journal of Neuroscience Research Effect of Cymbopogon citratus (Lemon Grass) on acute anoxic stress in mice Solomon Umukoro*, Adegoke L. Adekeye, Abayomi M. Ajayi, Somtochukwu I. Ogboh, Osarume Omorogbe, Adaeze Adebesin Neuropharmacology Unit, Department of Pharmacology and Therapeutics, University of Ibadan, Nigeria Exposure to acute anoxic stress produces deleterious effects on the brain through the formation of oxidant molecules like reactive oxygen species. Thus, compounds with antioxidant property might demonstrate protective effect against the damaging effects of anoxic stress on brain cells. This study was carried out to evaluate the protective effect of Cymbopogon citratus, a medicinal plant with antioxidant property on convulsions induced by anoxic stress in mice. Male Swiss mice (20-22 g) were given C. citratus (25, 50 and 100 mg/kg, p.o), Panax ginseng (50 mg/kg, p.o) or vehicle (10 mL/kg p.o). Thirty minutes later, the animals were exposed to anoxic stress and the latency (s) to convulsion (anoxic tolerance time) was measured. Thereafter, the blood glucose level was measured using glucometer. The levels of malondialdehyde (MDA) and glutathione (GSH) were also determined in the brain homogenates of mice subjected to anoxic stress. C. citratus (25, 50 and 100 mg/kg, p.o) did not significantly (p > 0.05) delay the latency to anoxic convulsion and also failed to alter the brain concentrations of MDA and GSH in mice exposed to anoxic stress. However, C. citratus (25, 50 and 100 mg/kg, p.o) caused a significant and dose-dependent reduction in the blood glucose levels in anoxic stressed mice. These findings suggest that C. citratus has neither protective effect against convulsive episodes nor alter oxidative stress parameters induced by acute anoxic stress in mice. The decrease in blood glucose produced by C. citratus in anoxic condition may be unconnected with normalization of deregulation of plasma glucose level during stress ...

Autophagy is up regulated in a neuronal model of charcot-marie tooth disease that overexpresses dynamin 2 mutant

Research Article of International Journal of Neuroscience Research Autophagy Is Up Regulated In A Neuronal Model Of Charcot-Marie Tooth Disease That Overexpresses Dynamin 2 Mutant Anu Shanu,1, 3, 5  Scott E. Stimpson, 1, 3, 4 Jens R. Coorssen†2,3,4,5 and Simon J. Myers†1,3,4,5 Western Sydney University,1Neuro-Cell Biology Laboratory, 2Molecular Physiology, 3Molecular Medicine Research Group, 4School of Science and Health, 5School of Medicine, Locked Bag 1797, NSW 2751, Australia Dominant-Intermediate Charcot-Marie-Tooth disease is one of the most common inherited disorders affecting the peripheral nervous system. Pleckstrin homology domain mutations in dynamin 2 cause dominant-intermediate Charcot Marie Tooth Syndrome. Autophagy in normal cells helps to maintain homeostasis and degrade damaged or old organelles and proteins. Here we link the pleckstrin homology domain mutants and the disease state to autophagy. Cells over-expressing the K558E mutation in the pleckstrin homology domain of dynamin 2 have shown an increase in expression of ER stress and autophagy markers. Although the exact link between autophagy and peripheral neurodegeneration has yet to be fully elucidated, these results set the foundation for further research into the interactions between dynamin 2 mutations, autophagy, and Dominant-Intermediate Charcot-Marie-Tooth. Keywords: DI-CMT, Dynamin II, autophagy, autophagosome ...

Dr. Mohd Normani Zakaria
Chairman / Head of Hospital Unit / Assistant Professor, Audiology and Speech Pathology Programme, Universiti Sains Malaysia

Dr. Darshana Narayanan
Head of Research, pymetrics, New York NY

Dr. Ayanabha Chakraborti
Senior Researcher, Department of Surgery, THT-1066, University of Alabama at Birmingham

Dr. Richa Madan Lomash
Research Fellow, Receptor Biology Unit (NINDS), NIH, Bethesda (MD), USA

Dr. Mario Bernardo-Filho
Professor Titular, Universidade do Estado do Rio de Janeiro

Dr. Dhruba Pathak
The University of Tennessee Health Science Center

Dr. Narayanaswamy Venketasubramanian Ramani
Consultant Neurologist, Raffles Hospital, Singapore

Dr. Abdelrahman Y. Fouda
Vascular Biology Center, R.B. Caldwell lab, Augusta University

Dr. Igor Iskusnykh
University of Tennessee Health Science Center

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1. Avinaba Mukherjee, Sourav Sikdar, Anisur Rahman Khuda-Bukhsh. Evaluation of ameliorative potential of isolated flavonol fractions from Thuja occidentalis in lung cancer cells and in Benzo(a) pyrene induced lung toxicity in mice. International Journal of Traditional and Complementary Medicine, 2016; 1(1): 0001-0013. 
2. Vikas Gupta, Parveen Bansal, Junaid Niazi, Kamlesh Kohli, Pankaj Ghaiye. Anti-anxiety Activity of Citrus paradisi var. duncan Extracts in Swiss Albino Mice-A Preclinical Study. Journal of Herbal Medicine Research, 2016; 1(1): 0001-0006.

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