International Journal of Neuroscience Research

Effect of Cymbopogon citratus (Lemon Grass) on acute anoxic stress in mice

Research Article of International Journal of Neuroscience Research Effect of Cymbopogon citratus (Lemon Grass) on acute anoxic stress in mice Solomon Umukoro*, Adegoke L. Adekeye, Abayomi M. Ajayi, Somtochukwu I. Ogboh, Osarume Omorogbe, Adaeze Adebesin Neuropharmacology Unit, Department of Pharmacology and Therapeutics, University of Ibadan, Nigeria Exposure to acute anoxic stress produces deleterious effects on the brain through the formation of oxidant molecules like reactive oxygen species. Thus, compounds with antioxidant property might demonstrate protective effect against the damaging effects of anoxic stress on brain cells. This study was carried out to evaluate the protective effect of Cymbopogon citratus, a medicinal plant with antioxidant property on convulsions induced by anoxic stress in mice. Male Swiss mice (20-22 g) were given C. citratus (25, 50 and 100 mg/kg, p.o), Panax ginseng (50 mg/kg, p.o) or vehicle (10 mL/kg p.o). Thirty minutes later, the animals were exposed to anoxic stress and the latency (s) to convulsion (anoxic tolerance time) was measured. Thereafter, the blood glucose level was measured using glucometer. The levels of malondialdehyde (MDA) and glutathione (GSH) were also determined in the brain homogenates of mice subjected to anoxic stress. C. citratus (25, 50 and 100 mg/kg, p.o) did not significantly (p > 0.05) delay the latency to anoxic convulsion and also failed to alter the brain concentrations of MDA and GSH in mice exposed to anoxic stress. However, C. citratus (25, 50 and 100 mg/kg, p.o) caused a significant and dose-dependent reduction in the blood glucose levels in anoxic stressed mice. These findings suggest that C. citratus has neither protective effect against convulsive episodes nor alter oxidative stress parameters induced by acute anoxic stress in mice. The decrease in blood glucose produced by C. citratus in anoxic condition may be unconnected with normalization of deregulation of plasma glucose level during stress ...

Autophagy is up regulated in a neuronal model of charcot-marie tooth disease that overexpresses dynamin 2 mutant

Research Article of International Journal of Neuroscience Research Autophagy Is Up Regulated In A Neuronal Model Of Charcot-Marie Tooth Disease That Overexpresses Dynamin 2 Mutant Anu Shanu,1, 3, 5  Scott E. Stimpson, 1, 3, 4 Jens R. Coorssen†2,3,4,5 and Simon J. Myers†1,3,4,5 Western Sydney University,1Neuro-Cell Biology Laboratory, 2Molecular Physiology, 3Molecular Medicine Research Group, 4School of Science and Health, 5School of Medicine, Locked Bag 1797, NSW 2751, Australia Dominant-Intermediate Charcot-Marie-Tooth disease is one of the most common inherited disorders affecting the peripheral nervous system. Pleckstrin homology domain mutations in dynamin 2 cause dominant-intermediate Charcot Marie Tooth Syndrome. Autophagy in normal cells helps to maintain homeostasis and degrade damaged or old organelles and proteins. Here we link the pleckstrin homology domain mutants and the disease state to autophagy. Cells over-expressing the K558E mutation in the pleckstrin homology domain of dynamin 2 have shown an increase in expression of ER stress and autophagy markers. Although the exact link between autophagy and peripheral neurodegeneration has yet to be fully elucidated, these results set the foundation for further research into the interactions between dynamin 2 mutations, autophagy, and Dominant-Intermediate Charcot-Marie-Tooth. Keywords: DI-CMT, Dynamin II, autophagy, autophagosome ...

Diet for stress full life

Review Article of International Journal of Neuroscience Research Diet for stress full life  Dr B V Pattabhiram*,Director Prasanthi Guidance & Counselling Centre, Hyderabad Dr Balaji Deekshitulu P V**, Psychologist & Alternative Medicine (Homeopathy) Practitioner, Sri Balaji Clinic, Tirupati, A.P, India. In this review article the author argues that complete presentation of various Indian diet can reduce the stress and related mental and physical illnesses like Stress anxiety, depression etc.. Life is neither Possible to overcome safely. Keywords: Stress, Diet, Vegetarian, Non- Vegetarian ...

ADHD for childrens in homeopathy & alternative methdos

Review Article of International Journal of Neuroscience Research ADHD for childrens in homeopathy & alternative methdos Dr Balaji Deekshitulu P V Psychologist & Alternative Medicine (Homeopathy) Practitioner, Sri Balaji Clinic, Tirupati, A.P, India. This review explained that homeopathy as rectified for attention deficit/hyperactivity disorder. Homeopathy and alternative methods like Diet &Herbal remedies are complete clear the symptoms, core symptoms or related outcomes of deficit/hyperactivity disorder. Keywords: ADHD, Diet, Herbal remedies, Homeopathy ...

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