International Journal of Traditional and Complementary Medicine



Useful Anti-Cancerous & Anti-tumorous Asian medicinal Plants (Taxus baccata L. or Taxus baccata Thunb., Catharanthus roseus(L.) G. Don, Annona muricata L.)

Review Article of International Journal of Traditional and Complementary Medicine Useful Anti-Cancerous & Anti-tumorous Asian medicinal Plants (Taxus baccata L. or Taxus baccata Thunb., Catharanthus roseus(L.) G. Don, Annona muricata L.) Pawan Kumar Sagar*1, R P Meena4, Mohd Washim Ahmad3, Kunal Sajwan4 *1.2,3. Drug StandardizationResearch Institute, (CCRUM., Ministry of AYUSH.), PLIM., Campus, Kamlanehru nagar, Ghaziabad, U.P. ,India; 4. Central Council for Research of Unani Medicine, Ministry of AYUSH., Janakpuri, D-Block, New Delhi, India Cancer is one of the harmful leading causes of death worldwide. Several synthetic agents have been used to cure the disease but they have their adverse side effects, low-hilling potential and toxicity.Present Article reviewed three important medicinal plants i.e.- Taxus baccata L. Or Taxus baccata Thunb., Catharanthus roseus(L.) G.Don and Annona muricata L. which traditionally used since ancient time for the treatment and prevention of Cancer and Tumor in Sothern, Northern-east and Himalayan region of India. Having active phytochemical constitutents Taxanes- Alkaloids(Taxol and Taxotere), Larotaxel,nab-Paclitaxel present in T. baccata L. Or T.baccata Thunb. and Vinca-Alkaloid as Vinblastine, Vincristine, Vinorelbine, Vinflunine, catharanthine and vindoline alkaloids in Catharanthus roseus(L.) G.Don, as well as Muricin J, Muricin K, Muricin L, Cinnamic acid derivative, Coumaric acid hexose, Annomuricin A, Annomuricin B, Annomuricin C, Annomuricin E, Annomutacin, Annhexocin, Muricatocin A, Muricatocin B, Muricatocin C, Giganletronenin, Annonacin A, Annopentocin A, Annopentocin B, Annopentocin C etc. present in A muricata L. This report also revealed the ethno-botanicaly and biological activities of active principles of these plants that will help in noval drug discovery, noval new active phytochemical constituents of anti-cancer and anti-tumor formulations and development of pharmacopial standareds. Keywords: Anti-cancerous, Anti-tumorous, medicinal plants, bio-actives constituents, bio available, ethno-botany ...

Standardization and HPTLC. Fingerprinting study of Poly Herbal Unani Formulation – Habb-e-Sara Khas

Research Article of International Journal of Traditional and Complementary Medicine Standardization and HPTLC. Fingerprinting study of Poly Herbal Unani Formulation - Habb-e-Sara Khas 1Pawan Kumar Sagar*,2R.Murugeswaran, 3Rampratap Meena, 4S. Mageswari and 5P. Meera Devi Sri, 6 Shahidul Khair 1&6Drug Standardization Research Institute, (Under CCRUM, Ministry of AYUSH., Govt. of India), PLIM Campus, IInd Floor, Kamla Nehru Nagar, Ghaziabad, U.P., India., 3Central Council for Research in Unani Medicine,(Under Ministry of AYUSH., Govt. of India),61-62, Institutional Area, Janakpuri, New Delhi, India.,4,5Drug Standardization Research Unit and 2Survey of Medicinal Plants Unit, Regional Research Institute of Unani Medicines, (Under CCRUM, Ministry of AYUSH., Govt. of India), Royapuram, Chennai, T.N., India. Standardization is used to describe all measures under taken during the manufacturing process and quality control of drug assuring its reproducible quality. Most of the traditional medicine are effective but still they lack in its standard parameters. Therefore, we need to develop standard techniques to standardize and validate herbal formulations. The drug Habb-e-Sara Khas is therapeutically useful in the treatment of Sara Khas (Epilepsy and Infantile epilepsy). The drug Habb-e-Sara Khas was prepared in three different batches as per the guidelines of National Formulary of Unani Medicine(Part-VI), Present study is aimed to evaluate the pharmacopoeial standards using physico-chemical parameters; HPTLC fingerprints, quality control and assurance parameters, using WHO guideline to ascertain the quality of drug. The physico-chemical data showed that the drug contain moisture(1.89%), total ash (5.43%),acid in-soluble(1.06%), alcohol and water soluble extractive matter (19.39%) and(60.34%),pH(1% solution) (5.93),pH(10% solution)(5.67), ASSE(18.07%) and CSSE (17.43%), Bulk density of granules(0.4989) and the TLC/HPTLC finger prints showed various spots at 254nm, 366nm and visible light (V-S reagent). The quality control study revealed the absence of microbial load, aflatoxins, heavy metals and pesticide residues, The evaluated standards will very much useful for laying the phamacopoeial standards of Habb-e-Sara Khas ...

Preparation and characterization of curcumin-loaded silica nanoparticles and their in-vivo anti-cancer activity evaluation

Research Article of International Journal of Traditional and Complementary Medicine Preparation and characterization of curcumin-loaded silica nanoparticles and their in-vivo anti-cancer activity evaluation Sonia Tyagi1, Deepak Yadav2, and Javed Abrar Farooqi1* 1School of Sciences, Indira Gandhi National Open University, New Delhi, India 2Miranda House College, University of Delhi, New Delhi, India Curcumin [(1E,6E)-1,7-bis (4-hydroxy- 3-methoxyphenyl) -1,6- heptadiene-3,5-dione)], a polyphenolic compound derived from dietary spice turmeric, has numerous biological and pharmacological activities. It is currently being used for treating several disorders, including cancer. Keeping in view its importance, the curcumin was embedded in the silica nanoparticles prepared by reaction of Tween-40, n-Butanol, triethoxyvinylsilane and 3-aminopropyltriethoxysilane using water as solvent. After completion of reaction, the nanoparticles were obtained by dialysis of the reaction mixture. The nanoparticles were characterized by SEM, TEM, DLS and XRD analyses. The SEM, TEM and DLS analysis shows the average particle size to be 70nm, 66 nm and 75.72nm respectively. Further in-vivo studies were conducted on wistar rats to determine the maximum tolerance dose (MTD) of nanoparticles and study the anti-cancer potential by tumor regression analysis. The MTD was found to be 10 mg/kg body weight of wistar rats and curcumin-doped ORMOSIL nanoparticles in comparison with pure curcumin revealed the highly significant results in tumor regression in EAT induced tumor model. Keywords: Silica nanoparticles, curcumin and EAT tumor model ...

Conceptualization of Traditional Healing System in Yoruba Worldviews

Review Article of International Journal of Traditional and Complementary Medicine Conceptualization of Traditional Healing System in Yoruba Worldviews Àjàlá, A.S; S.K, Ọlálẹ́yẹ; A. G, Adéjùmọ̀; I.T, Gbàdàmọ́sí; A.O, Adégòkè; M. A, Ṣónibáré; O. A, Ọdẹ́kù University of Ibadan Yoruba traditional healing system has being in practice for several centuries, yet, there are still certain complexities which set confusion in understanding its conceptualization. Due to lack of enough information about the practice, cynicism, religious bigotry against the practice and over-westernization of healthcare system in Yoruba society, basic features of Yoruba traditional healing system are still obscured. Conceptualization of the healing is narrowed and reduced to fetish; its epistemology is linked with Satan, and organization of Yoruba traditional healing is regarded as unscientific among other complexities suffered by the healing system. This continues to hamper the acknowledgment of its contributions to sustainable healthcare development. Through ethnographic data collection techniques using key informants’ interviews, observation, case study analysis and ethno-botanical survey conceptualization of traditional healing in Yoruba worldviews is examined. Despite the wave of social change influencing the practice of healing in Yoruba society, Yoruba traditional healing system is still resilient, rational and scientific. It features organization of service, providing all- inclusive health caring; with professionalization and specialization in health care service. Since Yoruba healing system is indigenous to the people, it has to be sustained by providing enough information that can explain and contextualize its practices. Keywords: Conceptualization, Yoruba healing system, Worldview, Classification, Specialization ...

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International Journal of Traditional and Complementary Medicine

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