International Journal of Traditional and Complementary Medicine



Popularization of traditional and complementary medicine: Urging voluminous effort driving towards scientific evaluation of safety and efficacy

Review Article of International Journal of Traditional and Complementary Medicine Popularization of traditional and complementary medicine: Urging voluminous effort driving towards scientific evaluation of safety and efficacy Papiya Bigoniya Principal, Radharaman College of Pharmacy, Ratibad, Bhopal, 462002, M.P., India Traditional medicines are widely used in developing countries with fast gaining popularity all over the world. Traditional medicine practices has long historical background that passes on from generation to generation. The quantity and quality, safety and efficacy of traditional medicine has became a worldwide concern emphasizing the need to develop harmonized international standards. The global market for herbal remedies is about $83 billion and growing at 10 to 20 percent yearly with the top global players like Germany, Asia, Japan, Europe and North America. Traditional therapies have a popular perception lower adverse effects rate as consumers perceive that natural sourced products are less likely to cause problems. The common causes of herbal product related adverse reaction occurrence are use toxic herbs, overdose, drug–herb interactions and idiosyncratic reactions. Herbal are mostly used over the counter without knowledge or advice of practitioner rising safety concern. Quality issues of traditional products are due to improper processing, adulteration, misidentification, missing of one or more herbs in a product, substitution, inclusion of prescription drugs, contamination and variability in active ingredient. Scientific study to assess safety and efficacy, composition, dosage form requirements are need of the time. Regulations governing the safety, quality and efficacy of traditional and complementary therapies vary widely from country to country and many countries do not have formal system for traditional and complementary medicine registration. Implementation of good manufacturing practice in cultivation, harvesting and processing along with chromatographic fingerprinting will greatly contribute to quality control of traditional medicines. Rigorous research is required for preclinical safety-efficacy, toxicology and clinical trials of traditional and complementary medicine. Boosting ...

Evaluation of ameliorative potential of isolated flavonol fractions from Thuja occidentalis in lung cancer cells and in Benzo(a)pyrene induced lung toxicity in mice

Research Article of International Journal of Traditional and Complementary Medicine Evaluation of ameliorative potential of isolated flavonol fractions from Thuja occidentalis in lung cancer cells and in Benzo(a)pyrene induced lung toxicity in mice Avinaba Mukherjee1, Sourav Sikdar1 and Anisur Rahman Khuda-Bukhsh1* 1Cytogenetics and Molecular Biology Laboratory, Department of Zoology, University of Kalyani, Kalyani-741235, West Bengal, India. Review method: Single-blind; Peer reviewer comments: 2. Relative anticancer potentials of six flavonol fractions (F1-F6) isolated from Thuja occidentalis extract were first evaluated against lung cancer cells A549 in vitro, and fraction- F4 showing the maximum protective ability, was then tested in mice intoxicated with Benzo(a)pyrene (BaP), a known carcinogen with major effect on lung, to learn if this could also have ameliorative action against lung toxicity and tissue damage in mice in vivo. Chemical nature of F1-F6 fractions was confirmed with specific flavonol confirmatory test and mass spectral analysis; all fractions were tested for their possible anticancer effects against A549 cells. Results suggested that fraction 4 (F4) had the strongest anticancer effect. When treated to BaP intoxicated mice, F4 induced recovery of damaged lung tissue, presumably through inhibition of ROS generation, and enhanced production of major antioxidant molecules, that in turn blocked PI3K-activated expressions of Akt. Decrease in Bcl2/Bax ratio, over-expression of p53 gene and activation of caspase 3 were observed in tissues of F4 treated mice, further confirming apoptotic cell death as its major target. The F4 fraction of Thuja occidentalis extract showed remarkable apoptotic potential against lung cancer cells and ameliorative ability against BaP induced lung toxicity. Keywords: Flavonol; benzo[a]pyrene toxicity; lung toxicity; PI3K/Akt pathway; reactive oxygen species (ROS), Thuja occidentalis ...

Editor-in-chief: 

Dr. Papiya Bigoniya Professor, Radharaman College of pharmacy, Radharaman Group of Institutes, India.

Editors:

Dr. Zhaoxiang Bian
Associate Vice-President, Chair Professor of School of Chinese Medicine, Director of Clinical Division and Associate Director of Institute of Creativity, Hong Kong Baptist University.

Dr. Woo-Sang Jung
Professor of Cardiology and Neurology (Stroke Center), College of Korean Medicine, Director of Korean Medical Emergency Room, Hospital of Korean Medicine, Kyung-Hee University.

Dr. M J Nanjan
Professor, Physical Chemistry (Retd.) of University of Madras, Chennai, India.

Dr. Daniel Man-yuen SZE
Deputy Program Coordinator for Master of Laboratory Medicine, School of Health & Biomedical Sciences and Health Innovations Research Institute (HIRi), RMIT University, Australia.

Dr. Shamim Ahmad
Professor of Microbiology, Officer In-Charge (Head) & Teacher In-Charge (Administrations), Microbiology Section, Institute of Ophthalmology, Faculty of Medicine , Aligarh Muslim University, India.

Dr. Qingwen Zhang
Associate Professor, Institute of Chinese Medical Sciences (ICMS), University of Macau.

Dr. Ansiur Rahman Khuda-Bukhsh
Former Head, Deptt. of Zoology, University of Kalyani, Presently an Emeritus Professor, University Grants Commission, Govt. of India, at  University of Kalyani.

Dr. Bajpayee Kaptain Kishor
Assistant Professor &HOD in the Botany Department, DR.RML P.G. COLLEGE (C.S.J.M. UNIVERSITY), HARDOI 241001 INDIA.

Dr. Hua-chuan Zheng
Professor, Cancer Research Center; Laboratory Animal Center; The Key Laboratory of Brain and Spinal Injury of Liaoning Province, Laboratory Animal Center, The First Affiliated Hospital of Liaoning Medical University, Jinzhou, China.

Dr. Emre Yalcinkaya
ESC Training Fellow in Electrophysiology, Clinic of Cardiology, University Hospital Zurich, Zurich, Switzerland.

Dr Zhi-Ling YU
Associate Professor, Teaching and Research Division, Fellow, Center for Cancer and Inflammation Research, Director, Master of Pharmaceutical Sciences in Chinese Medicine, Director, Consun Chinese Medicines Research Centre for Renal Diseases, Associate Director, Technology Development Division, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong

Dr. Mario Bernardo-Filho
Professor Titular, Universidade do Estado do Rio de Janeiro

Dr Shivani Sanjeev Gavande
Associate professor, Kayachikitsa at Dr. J.J.Magdum Ayurved medical college, Jaysingpur

Dr. Hiroyasu Satoh
Professor, Health Life Science, Shitennoji University, Habikino, Osaka 583-8501, Japan.

Dr. Paolo Roberti di Sarsina
Chairperson, Traditional Complementary and Alternative Medicine of the Observatory and Methods for Health, University of Milano-Bicocca, Milano, Italy.

Dr. Yibin Feng
Professor & Associate Director (Education), School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.

Dr. Afrozul Haq
Professor & Principal Scientist, R & D Division, VPS Healthcare, Abu Dhabi, United Arab Emirates (UAE).

Dr Manuel Fernandes Ferreira

Full Professor, Faculdade de Ciências da Universidade do Porto Rua do Campo Alegre, S/N Edifício FC4.Portugal.

Dr Jennifer Hunter
Senior Research Fellow, National Institute of Complementary Medicine, Western Sydney University, Australia.

Dr. Jiahong Lu
Assistant Professor, Institute of Chinese Medical Science, The University of Macau.

Dr. William Cho
Queen Elizabeth Hospital, Hong Kong.

Dr. Wenzhe Ma
Assistant Professor, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau.

Dr Swapnil Sabgonda Patil
Assistant Professor, Dept. of Rognidan Avum Vikrutividnyan

Dr. Hongjie Zhang
Associate Professor, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong.

Dr. Nitin Mantri
Senior Lecturer in Biotechnology, Health Innovations Research Institute, School of Science, RMIT University, Victoria,  Australia.

Dr Dudhamal Tukaram Sambhaji
Assistant Professor, Dept. of Shalya Tantra, IPGT&RA,Gujarat Ayurveda University, Jamnagar, Gujarat, India.

Dr Thomas Harris
Complex Health Management, 85 Jubilee Av. Forest Lake. Q 4078. Australia.

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1. M. B. FALANA, M. O. BANKOLE and A. M. OMEMU. In Vivo effects of dosage of leaf, bark and root extracts of V. paradoxa on diarhoea-induced albino rats.International Journal of Traditional and Complementary Medicine 2018, 3:8. DOI: 10.28933/ijtcm-2018-07-0401 
2. Hemanth Kumar Manikyam, C.Ramesh, Krishna Mohan Poluri, Harinath Reddy Kasireddy, Charitha Devi Mekala.Bio-enhancement effect of Bos primigenius indicus urine isolates on Curcumin anticancer activity using different human cell line models of A549, Hep-G2, MCF-7, Jurkat and K562 .International Journal of Traditional and Complementary Medicine 2017, 2:2. DOI: 10.28933/ijtcm-2017-11-2001 

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International Journal of Traditional and Complementary Medicine is a peer reviewed open access journal publishing research manuscripts, review articles, case reports, editorials, letters to the editor in Traditional and Complementary Medicine (indexing details).

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