Journal of Pharmaceutical Research and Reviews

Complexation of diclofenac sodium with hydroxy propyl betacyclodextrin improves its solubility and stability in ampoule solution which is determined by HPLC

Research Article of Journal of Pharmaceutical Research and Reviews Complexation of diclofenac sodium with hydroxy propyl betacyclodextrin improves its solubility and stability in ampoule solution which is determined by HPLC Kahtan J.Hasson Al-Rasheed University College,department of Pharmacy,Baghdad,Iraq Diclofenac sodium injection is widely used in medicine as antinflamatory and antirheumatic agent with a therapeutic value of 25 mg / ml. However, diclofenac sodium is poorly soluble which forms a problem in its manufacturing as an injection. The available commercial products of diclofenac sodium ampoules have used different types of solubilizing agents as benzyl alcohol which is an irritant in a concentration more than 3% while the other manufacturers used propylene glycol which has toxic impurities. In this present work, Diclofenac Sodium injection is prepared by using Hydroxy Propyl Beta Cyclodextrine ; a natural and safe excipient in formulation of ampoule solution which formed an inclusion complex compounds with Diclofenac Sodium ,render it very soluble and more stable. The finished product of ampoules were subjected to the stability study by storing the samples at 40°C and 75% RH for six months and the physico-chemical properties of the samples were tested at different periods. The results showed no change in appearance of the ampoules solution along the study time .In addition a reversed –phase high pressure liquid chromatographic method was developed and applied in studying the behavior of diclofenac Sodium in solution and its resistance to the high temperature challenger. The developed HPLC method was proved to be accurate and able to detect the degradation products of Diclofenac Sodium in solution. Keywords:Diclofenac sodium, Hydroxy propyl beta-cyclodextrin (HPB-CD), inclusion complex, Chromatography HPLC ...

Estimation of Some Phytochemicals in Swietenia macrophylla Leaves

Research Article of Journal of Pharmaceutical Research and Reviews Estimation of Some Phytochemicals in Swietenia macrophylla Leaves *1Ushie O. A, 2Neji, P. A, 3Muktar, M, 2Ogah, E, 1Longbab, B.D and 1Olumide.V.B 1Department of Chemical Science, Federal University Wukari, Nigeria 2Department of Science Laboratory Technology, Binyaminu Usman Polytechnic, Hadejia. Jigawa State, Nigeria 3Dept of Chemical Sciences, Cross River University of Technology Calabar, Nigeria Extract of the leaf for the detection of the phytochemicals were obtained by soaking 100g of the sample in 250ml ethanol for forty-eight hours with frequent agitation. The phytochemical screening of Swietenia macrophylla showed that tannin, phenol, flavonoid, terpenoids and alkaloids are present in the leaf extract. Quantitative determination of the detected secondary metabolites was carried out to know their percentages in the S. macrophylla leaves.The quantitative estimation of phytochemicals revealed that the various phytochemical constituents present in the leaf extract. In leaf extract of Swietenia macrophylla, the alkaloid content was 0.045 (9%), flavonoids content was 0.062 (12.4%), phenol content was 0.032 (6.4%) and tannin content was 0.043 (8.6%). Keywords: Estimation, Phytochemicals, Swietenia macrophylla Leaves ...

Proximate Analysis and Phytochemeical Screening on Root of Cnidoscolus carumbium

Research Article of Journal of Pharmaceutical Research and Reviews Proximate Analysis and Phytochemeical Screening on Root of Cnidoscolus carumbium *Neji, P. A1, Ushie O. A2, Alobi, N. O3, Neji, H. A4 and Etim, A. N5 1,3& 5Dept of Chemical Sciences, Cross River University of Technology, Calabar Nigeria 2Dept of Chemical Sciences, Federal University, Wukari Nigeria 4Dept of Science Education, University of Calabar, Nigeria The root of Cnidoscolus carumbium was soaked in water for 48 hours and filtered. The residue was oven dried at 800C for 4hrs. Further extraction process was done on the residue by soxhlet extraction method using different organic solvent mixtures of 500cm3 of hexane, acetone and methanol in the ratio 3:1:1 mixture. Proximate analysis for roots revealed Moisture content (19.1%), Fiber (17.7%), Crude protein (2.2%), Ash (15.5%), crude fat (1.0%), and carbohydrate (44.5%), indicating high nutritional value. The result for the extraction shows the presence of phytochemicals such as saponin, alkaloid, steroid flavonoid, phenol, tannin, cardiac glycosides, terpenoid and phlobatanin due to the solvent mixture possessing wide polarity thereby enabling the extraction of all the phytochemicals. Keywords: Proximate Analysis, Phytochemeical Screening, Root, Cnidoscolus carumbium ...

An Overview On Diabetes

Review Article of Journal of Pharmaceutical Research and Reviews An Overview On Diabetes R.Ramasubramania raja M.Sekar P.Lathasri, Paula preethi Department of Pharmacognonsy, Narayana Pharmacy college, Nellore, A.P In India more than 62 million diabetic individuals currently diagnosed with the disease. The prevalence of diabetes is more in India and is increasing rapidly. Herbal formulations are preferred due to lesser side effects and low cost. A list of medicinal plants with proven antidiabetic and related beneficial effects of herbal drug used in treatment of diabetes is compiled. Keywords: diabetic, India, Herbal formulations, Treatment ...

Dr. Rakesh Kumar Dixit
Professor, Department of Pharmacology & Therapeutics, King George’s Medical University Lucknow

Dr. Mahavir Chhajed
M. Pharm. (Pharm. Chemistry), Associate Professor

Dr Yusra Habib Khan
University Sains Malaysia

Dr. Tauqeer Hussain Mallhi
School Of Pharmaceutical Sciences, Usm, Penang, Malaysia

Lecturer in Pharmacy, Department of Basic Medical Sciences, Faculty of Pharmacy, Hajvery University

Dr Viraj H Mankar
Assistant Professor, Lovely Professional University

Dr. Dhananjay Kumar Singh
Molecular Bio-prospection Department, CSIR-CIMAP

Dr. Theophine Akunne 
Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka 410001, Nigeria

Dr Yassine MAHDI
Laboratory of Pharmaceutical Engineering, University of Sciences and Technology Houari Boumediene

Dr. Hamzah Maswadeh
Associate Prof. Head of Department of Pharmaceutics, College of Pharmacy – Qassim University -KSA

Dr. Vandna Kukshal
Department of Internal medicine, Washington University School of Medicine

M Nurul Amin
Department of Pharmacy, Atish Dipankar University of Science and Technology

Dr. Marwa A. Fouad
Associate Professor, Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University

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1. Avinaba Mukherjee, Sourav Sikdar, Anisur Rahman Khuda-Bukhsh. Evaluation of ameliorative potential of isolated flavonol fractions from Thuja occidentalis in lung cancer cells and in Benzo(a) pyrene induced lung toxicity in mice. International Journal of Traditional and Complementary Medicine, 2016; 1(1): 0001-0013. 
2. Vikas Gupta, Parveen Bansal, Junaid Niazi, Kamlesh Kohli, Pankaj Ghaiye. Anti-anxiety Activity of Citrus paradisi var. duncan Extracts in Swiss Albino Mice-A Preclinical Study. Journal of Herbal Medicine Research, 2016; 1(1): 0001-0006.

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Journal of Pharmaceutical Research and Reviews