Journal of Pharmaceutical Research and Reviews


Utility of Marine Organisms as a Drug Source: the Perspective

Review Article of Journal of Pharmaceutical Research and Reviews Utility of Marine Organisms as a Drug Source: the Perspective Pt. (Dr.) Kartikay Pandey¹*, Chakra Chalamala² ¹Researcher, “Dr. Pandey's Laboratories and Research Foundation", Lucknow, India. ²7150 North Maple Avenue, Fresno CA, 93720, USA. More than 70% of our planet’s surface is covered with sea/salty water. Even the world's oldest, most revered and holiest texts, the Vedas, term the Ocean as ‘Ratnakar’, or the bestower of immense riches. From pre-historic times the ocean/marine world has been a source of inspiration, awe & adventure for Mankind. Contemporary science discovered potent bioactive, chemical compounds from marine organisms not before 1950s, for the first time. At present, several potent cytotoxic and anticancer drug leads, from secondary metabolites biosynthesized in Marine invertebrates, have been identified, characterised and some of them have even been synthesized. In order to tackle the problem of supply, even artificial culture of Marine organisms has been successfully attempted. Some of such vital aspects are discussed here. Keywords: Marine Organisms, Drug Source, Perspective ...

Alkaloids an overview

Review Article of Journal of Pharmaceutical Research and Reviews Alkaloids – an overview R.Ramasubramania raja, M.Likitha, M.Sekar Department of pharmacognosy, narayana pharmacy college Nellore,A.P Alkaloids are a chemically heterogenous group of natural substances and comprises more than 6000 basic nitrogen containing organic compounds which occur in about 15 percent of all vascular terrestrial plants and in more than 150 different plants families. The alkaloids exhibit diversity of structures and also show an extraordinary spectrum of pharmacological activities. Because of these characters, they are important for chemical, physiological, taxonomic and biogenetic studies. Keywords: Alkaloids, organic, spectrum, taxonomic ...

Molar characterization and analytical UPLC method development of matrix impurity, disregards impurity, specified impurity associated undetectable impurity of laboratory drug Isatin

Review Article of Journal of Pharmaceutical Research and Reviews Molar characterization and analytical UPLC method development of matrix impurity, disregards impurity, specified impurity associated undetectable impurity of laboratory drug Isatin Rahul Hajare Post Doc Fellow (Batch 2013-2015) Indian Council of Medical Research, New Delhi This is out line work on the process development for the impurity detection of Isatin from synthetic occurring and several new methods have been developed during the pursuit of this research. The article traces the evolution of various approaches and provides a comparison for overall efficiency. UPLC method has been developed and validated for simultaneous estimation of matrix impurity, disregards impurity; specified impurity associated undetectable impurity in pure synthetic formulations. Separation was carried out using column Hypersil ODS C18 (250 mm x 4.6mm x 5μm particle size) in isocratic mode using mobile phase composition pH 6.0 ammonium acetate Buffer: Acetonitrile (68:32)v/v and UV detection at 310 nm. The impurities were eluted at a flow rate of 1.0 mL/ min. The average retention times for matrix impurity, disregards impurity, specified impurity associated undetectable impurity were 2.86 and 3.67 min, 4.54 min respectively. The method was validated according to the ICH guidelines. Keywords: Matrix impurity, disregards impurity, specified impurity associated undetectable impurity, UPLC, ICH guidelines, process development ...

Lead Developer Angular and Effect of Force by Side Chain of Suicide Molecule in HIV AIDS Drug Discovery

Review Article of Journal of Pharmaceutical Research and Reviews Lead Developer Angular and Effect of Force by Side Chain of Suicide Molecule in HIV AIDS Drug Discovery Rahul Hajare Post Doc Fellow (Batch 2013-2015) Indian Council of Medical Research, New Delhi Angular to lead (A2L) accepted as lead generation has stage in early drug discovery where small molecule hits from a high throughput screen (HTS) has evaluated and undergo limited optimization to identify promising lead compounds. These lead compounds undergo more extensive optimization in a subsequent step of drug discovery. Angular imagination → Target validation (TV) → assay development → high-throughput screening → hit to lead (H2L) → lead optimization (LO) → preclinical drug development → clinical drug development ...

Dr. Rakesh Kumar Dixit
Professor, Department of Pharmacology & Therapeutics, King George’s Medical University Lucknow

Dr. Mahavir Chhajed
M. Pharm. (Pharm. Chemistry), Associate Professor

Dr Yusra Habib Khan
University Sains Malaysia

Dr. Tauqeer Hussain Mallhi
School Of Pharmaceutical Sciences, Usm, Penang, Malaysia

Dr. TANVEER AHMED KHAN
Lecturer in Pharmacy, Department of Basic Medical Sciences, Faculty of Pharmacy, Hajvery University

Dr Viraj H Mankar
Assistant Professor, Lovely Professional University

Dr. Dhananjay Kumar Singh
Molecular Bio-prospection Department, CSIR-CIMAP

Dr. Theophine Akunne 
Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka 410001, Nigeria

Dr Yassine MAHDI
Laboratory of Pharmaceutical Engineering, University of Sciences and Technology Houari Boumediene

Dr. Hamzah Maswadeh
Associate Prof. Head of Department of Pharmaceutics, College of Pharmacy – Qassim University -KSA

Dr. Vandna Kukshal
Department of Internal medicine, Washington University School of Medicine

M Nurul Amin
Department of Pharmacy, Atish Dipankar University of Science and Technology

Dr. Marwa A. Fouad
Associate Professor, Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University

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1. Avinaba Mukherjee, Sourav Sikdar, Anisur Rahman Khuda-Bukhsh. Evaluation of ameliorative potential of isolated flavonol fractions from Thuja occidentalis in lung cancer cells and in Benzo(a) pyrene induced lung toxicity in mice. International Journal of Traditional and Complementary Medicine, 2016; 1(1): 0001-0013. 
2. Vikas Gupta, Parveen Bansal, Junaid Niazi, Kamlesh Kohli, Pankaj Ghaiye. Anti-anxiety Activity of Citrus paradisi var. duncan Extracts in Swiss Albino Mice-A Preclinical Study. Journal of Herbal Medicine Research, 2016; 1(1): 0001-0006.

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Journal of Pharmaceutical Research and Reviews

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