Journal of Pharmaceutical Research and Reviews


Development and Validation of Rp-HPLC Method for Analysis of Raloxifene in Pharmaceutical Dosage Forms

Research Article of Journal of Pharmaceutical Research and Reviews Development and Validation of Rp-HPLC Method for Analysis of Raloxifene in Pharmaceutical Dosage Forms Venu Manukonda1, Shaheen Sultana2*, Amit Singh3, Maria Khan2, Mohammad Yusuf2, Ibrahim Abdullah Maghrabi2 1RV Northland Institute;2Taif University, Saudi Arabia;3RV Northland Institute The aim of present work was to develop and validate a simple, fast and reliable isocratic HPLC method for determination of raloxifene hydrochloride in pharmaceutical dosage form. Chromatographic Separation was achieved by using Agilent technologies model G4288A. Gradient HPLC-1120 , Compact low pressure binary Gradient Pump Consisting Of vacuum in built degasser unit non-PDA UV-vis detector equipped with a manual injection system with 50 uL loop and the eluted analytes for drug was traced by UV detection at 287nm. The method was found to be linear over a wide concentration range (0.1-20 µg/mL) with a correlation coefficient (r) of 0.9995. The LOD and LOQ were 21 and 63 ng/mL for RLX. These results indicate that method is sensitive enough for therapeutic assay. The % RSD values for three selected concentrations were found to be 0.14, 0.51 and 0.75% revealed the high system accuracy. The relative standard deviations (RSD) obtained at three concentrations (n = 6) in the range of 8-10 µg/mL was 0.016-0.018 % for the intraday assay and 0.016-0.024% for interday assay revealed good precision. The specificity was demonstrated that drugs were free of interference from potential impurities. % RSD, theoretical plates and Rmin were not significantly affected when the experimental parameters (such as flow rate, gradient program) were altered and thus concluded that the method was robust. Keywords: Raloxifene; HPLC, linearity, robustness ...

Medicinal plants used to treat the disease of gout –an overview

Review Article of Journal of Pharmaceutical Research and Reviews Medicinal plants used to treat the disease of gout –an overview R.Ramasubramania raja M.Sekar, P.Lathasri,I.Paula Preethi,M.Suma Bhavana,T.Swathi Department of Pharmacognosy, Narayana Pharmacy College, Nellore, A.P Gout also called as hyper uricemia. Gout is characterized by sudden, severe attacks of pain, redness and tenderness in joints, often the joint at the base of big toe. Gout is a condition that develops when Uric acid is not properly excreted from the blood through urine .Excess uric acid builds up in the body and when not removed by the kidneys, it deposits in the form of crystals in the joints, primarily in hands and feet and especially in the joint of big toe. The risk of developing gout increases as the Serum uric acid level rises [>7 mg/dl]. In our focus medicinal plants used to treat the gout for the reason in the allopathic system of medicine is not cure the disease of gout, its only controlled. So few medicinal plants we reviewed this paper. Keywords: Gout, uricemia, pain, serum, medicinal plants ...

Electrochemical study of methimazole and its direct determination in pharmaceutical preparations and human serum by square wave and differential pulse voltammetry

Review Article of Journal of Pharmaceutical Research and Reviews Electrochemical study of methimazole and its direct determination in pharmaceutical preparations and human serum by square wave and differential pulse voltammetry Bilal Yilmaz1 , Fatma Bayrakceken Nisanci2* 1Department of Analytical Chemistry, Faculty of Pharmacy, Ataturk University, 25240, Erzurum, Turkey; 2Department of Chemistry, Faculty of Science, Ataturk University, 25240, Erzurum, Turkey Two simple and rapid methods were developed for the determination of methimazole in pharmaceutical preparations and human serum by square wave and differential pulse voltammetry. The anodic peak at +0.60 V obtained in a buffer on glassy carbon electrode was used for analysis. The peak current and peak potential depend on pH, scan rate and initial potential. Decrease of the anodic peak with increasing pH, as well as deviations from linear plots of ip = f(C) and ip = f(C) and ip = kv1/2 indicate that this peak at higher concentrations is affected by adsorption-desorption phenomena. The linearity was established over the concentration range of 10-80 ug/mL for both methods in supporting electrolyte and human serum. The repeatability and reproducibility of the methods for all media (such as supporting electrolyte and serum samples) were determined. Precision and accuracy were also checked in all media. Developed methods in this study can be applied to Thyromazol tablet. Also, the proposed techniques were successfully applied to spiked human serum samples. No electroactive interferences from the endogenous substances were found in the serum samples. Keywords: Methimazole, serum, voltammetry, tablet ...

Medicinal plant used in the treatment of dengue fever-an overview

Review Article of Journal of Pharmaceutical Research and Reviews Medicinal plant used in the treatment of dengue fever-an overview R.Ramasubramania raja, M.Sekar, I.Paula Preethi S.Thanuja,M.Sumabhavana, P.Lathasri, A.C.Nikhila Teja Department of Pharmacognosy, Narayana Pharmacy College, Nellore, A.P Dengue is an infectious diseases, it is caused by virus. It is transmitted by a mosquito of Aedes aegypti. Dengue produced in our body high fever, headache, joint pain and skin rashes. Allopathic system of medicine is not having the potential remedy for dengue fever. In ayurvedic system only cure the dengue fever, for example of papaya leaves, fenugreek, kiwi and wheatgrass etc., Without unwanted effect dengue is cure by this herbs. Keywords:  Dengue fever, papaya leaves, fenugreek, kiwi and wheatgrass ...

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Journal of Pharmaceutical Research and Reviews

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