Inflammatory bowel disease and amebiasis

Inflammatory bowel disease and amebiasis

Sanyour Joyce1,  Nakhoul Mary1, Saniour Philippe2, Abou Rached Antoine1
1Lebanese university, school of medicine, Hadath, Beirut
2Saint Joseph Hospital, Dora, Beirut

Open Journal of Gastroenterology and Hepatology

Amebiasis affects around 500 million people in the world. Clinical manifestations of intestinal amebiasis can overlap with symptoms of the inflammatory bowel disease (IBD). Many studies evaluated the relationship of IBD patients during exacerbation periods and amoebic colitis as it is important to rule out the infection before starting steroids and/or immunosuppressive treatment.
This mini-review focused on the best strategy to diagnose the infection in this specific population, using classical stool analysis for ova and parasites, serology, investigations by PCR and colonoscopy according to the degree of clinical suspicion.
It also suggested an algorithm for management approach where patients were divided into asymptomatic carriers vs. symptomatic patients under 5 ASA or immunosuppressive therapy having either a vegetative or cystic form of the infection. All these patients were treated accordingly by intraluminal agents, and nitroimidazole was added in the vegetative form. 5-ASA was not a contraindication for treatment, while immunosuppression is forbidden until after eradiation of EH.
Amoebic infection should always be ruled out before starting treatment with steroid or immunosuppressive medications, in order to minimize its deleterious outcomes on IBD patients.

Keywords: Inflammatory bowel disease, amebiasis, review

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How to cite this article:
Sanyour Joyce, Nakhoul Mary, Saniour Philippe, Abou Rached Antoine. Inflammatory bowel disease and amebiasis. Open Journal of Gastroenterology and Hepatology, 2019, 2:12. DOI: 10.28933/ojgh-2019-08-0205


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