Endoscopic Outcome of non complicated Gastric Ulcer following Standard Medical Treatment in sub-Saharan African Population

Endoscopic Outcome of non complicated Gastric Ulcer following Standard Medical Treatment in sub-Saharan African Population

Kowo MP1, Essouma M1, Ndjitoyap Ndam AW1, Wembe Sop BD2, Kenfack GU1, Guekam Ouamba P2, Ndjitoyap Ndam EC1, Njoya O1, Ankouane Andoulo F1

1Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Cameroon; 2Université des Montagnes Banganté Cameroon

Open Journal of Gastroenterology and Hepatology

Background.The endoscopic outcome of gastric ulcers is not well described in sub-Saharan Africa. This study was therefore conducted in order to track the endoscopic outcome of non complicated gastric ulcers following standard medical treatment in  sub-Saharan African population.

Methods.This was a prospective cohort study conducted from January to July 2018 in three tertiary healthcare centers in Yaounde (Cameroon).Gastric ulcers and gastric H. pylori infection were diagnosed and monitored by upper digestive endoscopy performed before and at least four weeks following treatment with proton pump inhibitors alone or combined with antibiotics depending on H. pylori status.  A complete case analysis was done using the SPSS software, version 21.0. p-values ≤0.05 were considered as significant.

Results. Ninety-six patients (54.2% males) with a mean age of 55.3 ± 14.9 years were initially enrolled. In most patients, the ulcer frequently was unique (76%) and the antrum was the commonest localization 76 (79.2%). Among patients with H. pylori infection, the quadruple therapy was the most prescribed treatment 41 (87.2%) patients. There were 60 (62.5%) subjects lost to follow-up. Of the 36 (37.5%) patients who underwent repeat endoscopy, 26 (72.2%) had ulcer healing and 8/13 patients had successful H. pylori eradication. A delay of repeat endoscopy >8 weeks was the only predictor of non-healing of the ulcer: relative risk 0.6[95% CI: 0.3-1.08], p = 0.05.

Conclusion.Ulcer healing was found in nearly 2/3 of patients and H. pylori eradication in almost ¾ of patients. This study should be repeated in a large sample.

Keywords: Gastric ulcer, endoscopic outcome, standard medical treatment, sub-Saharan Africa.

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How to cite this article:
Kowo MP, Essouma M, Ndjitoyap Ndam AW, Wembe Sop BD, Kenfack GU, Guekam Ouamba P, Ndjitoyap Ndam EC, Njoya O, Ankouane Andoulo F. Endoscopic Outcome of non complicated Gastric Ulcer following Standard Medical Treatment in sub-Saharan African Population. Open Journal of Gastroenterology and Hepatology, 2020, 3:39. DOI: 10.28933/ojgh-2020-06-1505


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