Pure alphafetoprotein producing neuroendocrine carcinoma of the stomach: A case report


Pure alphafetoprotein producing neuroendocrine carcinoma of the stomach: A case report


Chen-Wei Chu1, Chien-ho Tsai2, Yu-Huan Huang3, Chun-I Tsai4, Swei-hsiung H Tsung5

1.Department of Medicine, Taipei Veterans General Hospital, Yuanshan branch, Yuanshan, Yilan, Taiwan.
2.Deparment of surgery, National Yang-Ming University Hospital, Yilan.Taiwan.
3.Department of Nursing, National Yang-Ming University Hospital, Yilan, Taiwan
4.Chun-I Tsai Medical Clinic. Yilan, Taiwan.
5.Department of Pathology, St Mary’s Hospital, Loudong, Yilan, Taiwan


Alpha-fetoprotein-producing gastric carcinoma (AFP-GC) is a rare malignant tumor, and has been regarded as a distinct category because of its particularly aggressive biological behavior and poor patient prognosis. In the literature, AFP-GC was never reported in neuroendocrine carcinoma of the stomach. In this article, we described a 60-year old man who sought medical attention because of epigastric pain and poor appetite. His laboratory data were within normal limits except for elevated serum level of alpha-fetoprotein. He was found to have an ulcer on gastroscopic examination which led to the final diagnosis of AFP producing neuroendocrine carcinoma of the stomach. He underwent a radical gastrectomy followed by chemotherapy using leucovorin and 5-fluorouracil.His disease was brought under remission for only six months before radiological recurrence occurred. His recurrent disease was treated with irinotican plus cisplatin without a significant response. His prognosis looked grave. We reported the first case of AFP producing gastric neuroendocrine carcinoma to share our experience.


Keywords: gastric cancer. Alpha-fetoprotein. Neuroendocrine carcinoma. Chemotherapy. Immunohistochemical stainings. Radiological recurrence.

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How to cite this article:
Chen-Wei Chu, Chien-ho Tsai, Yu-Huan Huang, Chun-I Tsai, Swei-hsiung H Tsung. Pure alphafetoprotein producing neuroendocrine carcinoma of the stomach: A case report.Open Journal of Gastroenterology and Hepatology, 2020, 3:41.. DOI: 10.28933/ojgh-2020-09-1307


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